P48059: LIM and senescent cell antigen-like-containing domain protein 1
Protein names | - LIM and senescent cell antigen-like-containing domain protein 1 - Particularly interesting new Cys-His protein 1 - PINCH-1 - Renal carcinoma antigen NY-REN-48 |
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Gene names | LIMS1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P48059 |
4
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE
70 80 90 100 110 120
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP
130 140 150 160 170 180
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY
190 200 210 220 230 240
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC
250 260 270 280 290 300
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC
310 320
KKCYEKFPLE LKKRLKKLAE TLGRK
Isoforms
- Isoform 2 of LIM and senescent cell antigen-like-containing domain protein 1 - Isoform 3 of LIM and senescent cell antigen-like-containing domain protein 1 - Isoform 4 of LIM and senescent cell antigen-like-containing domain protein 1 - Isoform 5 of LIM and senescent cell antigen-like-containing domain protein 1Sequence View
10 20 30 40 50 60
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE
70 80 90 100 110 120
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP
130 140 150 160 170 180
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY
190 200 210 220 230 240
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC
250 260 270 280 290 300
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC
310 320
KKCYEKFPLE LKKRLKKLAE TLGRK
10 20 30 40 50 60
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE
70 80 90 100 110 120
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP
130 140 150 160 170 180
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY
190 200 210 220 230 240
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC
250 260 270 280 290 300
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC
310 320
KKCYEKFPLE LKKRLKKLAE TLGRK
10 20 30 40 50 60
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE
70 80 90 100 110 120
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP
130 140 150 160 170 180
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY
190 200 210 220 230 240
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC
250 260 270 280 290 300
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC
310 320
KKCYEKFPLE LKKRLKKLAE TLGRK
10 20 30 40 50 60
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE
70 80 90 100 110 120
HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP
130 140 150 160 170 180
CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY
190 200 210 220 230 240
CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC
250 260 270 280 290 300
ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC
310 320
KKCYEKFPLE LKKRLKKLAE TLGRK
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P48059-2-unknown | MANALA... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P48059-1-unknown | MANALA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96765 | |||
P48059-1-unknown | MANALA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96767 | |||
P48059-1-unknown | MANALA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96764 | |||
P48059-1-unknown | MANALA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96766 | |||
P48059-2-Acetylation | ANALAS... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P48059-2-Acetylation | ANALAS... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P48059-2-Acetylation | ANALAS... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P48059-2-Acetylation | ANALAS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110124 | ||
P48059-2-Acetylation | ANALAS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110126 | ||
P48059-2-Acetylation | ANALAS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110123 | ||
P48059-2-Acetylation | ANALAS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110125 | ||
P48059-107-unknown | IGFVKN... | 107 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11554 | |||
P48059-107-unknown | IGFVKN... | 107 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142984 | |||
P48059-107-unknown | IGFVKN... | 107 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143413 | |||
P48059-107-unknown | IGFVKN... | 107 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144479 | |||
P48059-107-unknown | IGFVKN... | 107 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145480 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...EVLADI | 106 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11554 | |||
...EVLADI | 106 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126192 | |||
...EVLADI | 106 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126646 | |||
...EVLADI | 106 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127744 | |||
...EVLADI | 106 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128776 | |||
...TLGRK | 325 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...TLGRK | 325 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75223 | |||
...TLGRK | 325 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75221 | |||
...TLGRK | 325 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75224 | |||
...TLGRK | 325 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75222 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 106 | LADI.|.IGFV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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