P48163: NADP-dependent malic enzyme

General Information

Protein names	- NADP-dependent malic enzyme - NADP-ME - 1.1.1.40 - Malic enzyme 1
Gene names	ME1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P48163

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEPEAPRRRH THQRGYLLTR NPHLNKDLAF TLEERQQLNI HGLLPPSFNS QEIQVLRVVK
        70         80         90        100        110        120
NFEHLNSDFD RYLLLMDLQD RNEKLFYRVL TSDIEKFMPI VYTPTVGLAC QQYSLVFRKP
       130        140        150        160        170        180
RGLFITIHDR GHIASVLNAW PEDVIKAIVV TDGERILGLG DLGCNGMGIP VGKLALYTAC
       190        200        210        220        230        240
GGMNPQECLP VILDVGTENE ELLKDPLYIG LRQRRVRGSE YDDFLDEFME AVSSKYGMNC
       250        260        270        280        290        300
LIQFEDFANV NAFRLLNKYR NQYCTFNDDI QGTASVAVAG LLAALRITKN KLSDQTILFQ
       310        320        330        340        350        360
GAGEAALGIA HLIVMALEKE GLPKEKAIKK IWLVDSKGLI VKGRASLTQE KEKFAHEHEE
       370        380        390        400        410        420
MKNLEAIVQE IKPTALIGVA AIGGAFSEQI LKDMAAFNER PIIFALSNPT SKAECSAEQC
       430        440        450        460        470        480
YKITKGRAIF ASGSPFDPVT LPNGQTLYPG QGNNSYVFPG VALGVVACGL RQITDNIFLT
       490        500        510        520        530        540
TAEVIAQQVS DKHLEEGRLY PPLNTIRDVS LKIAEKIVKD AYQEKTATVY PEPQNKEAFV
       550        560        570
RSQMYSTDYD QILPDCYSWP EEVQKIQTKV DQ

Isoforms

- Isoform 2 of NADP-dependent malic enzyme

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P48163-1-Acetylation	MEPEAP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P48163-1-Acetylation	MEPEAP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P48163-1-Acetylation	MEPEAP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P48163-76-unknown	MDLQDR...	76		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446114
P48163-167-unknown	MGIPVG...	167		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439912
P48163-382-unknown	IGGAFS...	382		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3807

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...IGVAAI	381	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3807
	...TKVDQ	572	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	381	VAAI.\|.IGGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)