TopFIND 4.0

P48507: Glutamate--cysteine ligase regulatory subunit

General Information

Protein names
- Glutamate--cysteine ligase regulatory subunit
- GCS light chain
- Gamma-ECS regulatory subunit
- Gamma-glutamylcysteine synthetase regulatory subunit
- Glutamate--cysteine ligase modifier subunit
Gene names GCLM
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P48507

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGTDSRAAKA LLARARTLHL QTGNLLNWGR LRKKCPSTHS EELHDCIQKT LNEWSSQINP 
        70         80         90        100        110        120 
DLVREFPDVL ECTVSHAVEK INPDEREEMK VSAKLFIVES NSSSSTRSAV DMACSVLGVA 
       130        140        150        160        170        180 
QLDSVIIASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ 
       190        200        210        220        230        240 
VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIQAH 
       250        260        270    
EWVPLWLLRY SVIVKSRGII KSKGYILQAK RRGS

Isoforms

- Isoform 2 of Glutamate--cysteine ligase regulatory subunit

Sequence View

        10         20         30         40         50         60 
MGTDSRAAKA LLARARTLHL QTGNLLNWGR LRKKCPSTHS EELHDCIQKT LNEWSSQINP 
        70         80         90        100        110        120 
DLVREFPDVL ECTVSHAVEK INPDEREEMK VSAKLFIVES NSSSSTRSAV DMACSVLGVA 
       130        140        150        160        170        180 
QLDSVIIASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ 
       190        200        210        220        230        240 
VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIQAH 
       250        260        270    
EWVPLWLLRY SVIVKSRGII KSKGYILQAK RRGS



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P48507-1-unknown MGTDSR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P48507-50- TLNEWS... 50 N-TAILS Overall Laboratory Lange_Huesgen_et_al-RBC
    P48507-56- SQINPD... 56 N-TAILS Overall Laboratory Lange_Huesgen_et_al-RBC

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KRRGS 274 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)