P48723: Heat shock 70 kDa protein 13

General Information

Protein names	- Heat shock 70 kDa protein 13 - Microsomal stress-70 protein ATPase core - Stress-70 protein chaperone microsome-associated 60 kDa protein
Gene names	HSPA13
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P48723

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP GTGKVKVIPD
        70         80         90        100        110        120
ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK RFIGKIFTAE ELEAEIGRYP
       130        140        150        160        170        180
FKVLNKNGMV EFSVTSNETI TVSPEYVGSR LLLKLKEMAE AYLGMPVANA VISVPAEFDL
       190        200        210        220        230        240
KQRNSTIEAA NLAGLKILRV INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG
       250        260        270        280        290        300
GMFLTRAMSG NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT
       310        320        330        340        350        360
LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS DKKSGESQVL
       370        380        390        400        410        420
FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID EVVLVGGSTR IPRIRQVIQE
       430        440        450        460        470
FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS WPLQVSALEI PNKHLQKTNF N

Isoforms

Sequence View

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Directness:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P48723-5-unknown	MTILGS...	5	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P48723-23-unknown	QQYLPL...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P48723-24-	QYLPLP...	24		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P48723-24-	QYLPLP...	24		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P48723-24-	QYLPLP...	24		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P48723-24-	QYLPLP...	24		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P48723-24-unknown	QYLPLP...	24		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P48723-159-unknown	AEAYLG...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11566
P48723-209-unknown	MAYGLH...	209	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441986

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KLKEMA	158	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11566
	...KTNFN	471	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	158	KEMA.\|.AEAY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)