P49590: Probable histidine--tRNA ligase, mitochondrial

General Information

Protein names	- Probable histidine--tRNA ligase, mitochondrial - 6.1.1.21 - Histidine--tRNA ligase-like - Histidyl-tRNA synthetase - HisRS
Gene names	HARS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49590

4 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPLLGLLPRR AWASLLSQLL RPPCASCTGA VRCQSQVAEA VLTSQLKAHQ EKPNFIIKTP
        70         80         90        100        110        120
KGTRDLSPQH MVVREKILDL VISCFKRHGA KGMDTPAFEL KETLTEKYGE DSGLMYDLKD
       130        140        150        160        170        180
QGGELLSLRY DLTVPFARYL AMNKVKKMKR YHVGKVWRRE SPTIVQGRYR EFCQCDFDIA
       190        200        210        220        230        240
GQFDPMIPDA ECLKIMCEIL SGLQLGDFLI KVNDRRIVDG MFAVCGVPES KFRAICSSID
       250        260        270        280        290        300
KLDKMAWKDV RHEMVVKKGL APEVADRIGD YVQCHGGVSL VEQMFQDPRL SQNKQALEGL
       310        320        330        340        350        360
GDLKLLFEYL TLFGIADKIS FDLSLARGLD YYTGVIYEAV LLQTPTQAGE EPLNVGSVAA
       370        380        390        400        410        420
GGRYDGLVGM FDPKGHKVPC VGLSIGVERI FYIVEQRMKT KGEKVRTTET QVFVATPQKN
       430        440        450        460        470        480
FLQERLKLIA ELWDSGIKAE MLYKNNPKLL TQLHYCESTG IPLVVIIGEQ ELKEGVIKIR
       490        500
SVASREEVAI KRENFVAEIQ KRLSES

Isoforms

- Isoform 2 of Probable histidine--tRNA ligase, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49590-34-unknown	QSQVAE...	34	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49590-35-	SQVAEA...	35		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P49590-35-	SQVAEA...	35		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49590-35-	SQVAEA...	35		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49590-35-	SQVAEA...	35		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49590-35-	SQVAEA...	35		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49590-35-	SQVAEA...	35		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P49590-35-	SQVAEA...	35		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49590-35-unknown	SQVAEA...	35		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49590-488-unknown	VAIKRE...	488	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11589

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKYGED	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424516
...EFCQCD	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425695
...ASREEV	487	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11589
...RLSES	506	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	487	REEV.\|.VAIK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)