P49754: Vacuolar protein sorting-associated protein 41 homolog

General Information

Protein names	- Vacuolar protein sorting-associated protein 41 homolog - S53
Gene names	VPS41
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49754

4 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Vacuolar protein sorting-associated protein 41 homolog - Isoform 3 of Vacuolar protein sorting-associated protein 41 homolog

Sequence View

        10         20         30         40         50         60
MAEAEEQETG SLEESTDESE EEESEEEPKL KYERLSNGVT EILQKDAASC MTVHDKFLAL
        70         80         90        100        110        120
GTHYGKVYLL DVQGNITQKF DVSPVKINQI SLDESGEHMG VCSEDGKVQV FGLYSGEEFH
       130        140        150        160        170        180
ETFDCPIKII AVHPHFVRSS CKQFVTGGKK LLLFERSWMN RWKSAVLHEG EGNIRSVKWR
       190        200        210        220        230        240
GHLIAWANNM GVKIFDIISK QRITNVPRDD ISLRPDMYPC SLCWKDNVTL IIGWGTSVKV
       250        260        270        280        290        300
CSVKERHASE MRDLPSRYVE IVSQFETEFY ISGLAPLCDQ LVVLSYVKEI SEKTEREYCA
       310        320        330        340        350        360
RPRLDIIQPL SETCEEISSD ALTVRGFQEN ECRDYHLEYS EGESLFYIVS PRDVVVAKER
       370        380        390        400        410        420
DQDDHIDWLL EKKKYEEALM AAEISQKNIK RHKILDIGLA YINHLVERGD YDIAARKCQK
       430        440        450        460        470        480
ILGKNAALWE YEVYKFKEIG QLKAISPYLP RGDPVLKPLI YEMILHEFLE SDYEGFATLI
       490        500        510        520        530        540
REWPGDLYNN SVIVQAVRDH LKKDSQNKTL LKTLAELYTY DKNYGNALEI YLTLRHKDVF
       550        560        570        580        590        600
QLIHKHNLFS SIKDKIVLLM DFDSEKAVDM LLDNEDKISI KKVVEELEDR PELQHVYLHK
       610        620        630        640        650        660
LFKRDHHKGQ RYHEKQISLY AEYDRPNLLP FLRDSTHCPL EKALEICQQR NFVEETVYLL
       670        680        690        700        710        720
SRMGNSRSAL KMIMEELHDV DKAIEFAKEQ DDGELWEDLI LYSIDKPPFI TGLLNNIGTH
       730        740        750        760        770        780
VDPILLIHRI KEGMEIPNLR DSLVKILQDY NLQILLREGC KKILVADSLS LLKKMHRTQM
       790        800        810        820        830        840
KGVLVDEENI CESCLSPILP SDAAKPFSVV VFHCRHMFHK ECLPMPSMNS AAQFCNICSA
       850
KNRGPGSAIL EMKK         10         20         30         40         50         60
MAEAEEQETG SLEESTDESE EEESEEEPKL KYERLSNGVT EILQKDAASC MTVHDKFLAL
        70         80         90        100        110        120
GTHYGKVYLL DVQGNITQKF DVSPVKINQI SLDESGEHMG VCSEDGKVQV FGLYSGEEFH
       130        140        150        160        170        180
ETFDCPIKII AVHPHFVRSS CKQFVTGGKK LLLFERSWMN RWKSAVLHEG EGNIRSVKWR
       190        200        210        220        230        240
GHLIAWANNM GVKIFDIISK QRITNVPRDD ISLRPDMYPC SLCWKDNVTL IIGWGTSVKV
       250        260        270        280        290        300
CSVKERHASE MRDLPSRYVE IVSQFETEFY ISGLAPLCDQ LVVLSYVKEI SEKTEREYCA
       310        320        330        340        350        360
RPRLDIIQPL SETCEEISSD ALTVRGFQEN ECRDYHLEYS EGESLFYIVS PRDVVVAKER
       370        380        390        400        410        420
DQDDHIDWLL EKKKYEEALM AAEISQKNIK RHKILDIGLA YINHLVERGD YDIAARKCQK
       430        440        450        460        470        480
ILGKNAALWE YEVYKFKEIG QLKAISPYLP RGDPVLKPLI YEMILHEFLE SDYEGFATLI
       490        500        510        520        530        540
REWPGDLYNN SVIVQAVRDH LKKDSQNKTL LKTLAELYTY DKNYGNALEI YLTLRHKDVF
       550        560        570        580        590        600
QLIHKHNLFS SIKDKIVLLM DFDSEKAVDM LLDNEDKISI KKVVEELEDR PELQHVYLHK
       610        620        630        640        650        660
LFKRDHHKGQ RYHEKQISLY AEYDRPNLLP FLRDSTHCPL EKALEICQQR NFVEETVYLL
       670        680        690        700        710        720
SRMGNSRSAL KMIMEELHDV DKAIEFAKEQ DDGELWEDLI LYSIDKPPFI TGLLNNIGTH
       730        740        750        760        770        780
VDPILLIHRI KEGMEIPNLR DSLVKILQDY NLQILLREGC KKILVADSLS LLKKMHRTQM
       790        800        810        820        830        840
KGVLVDEENI CESCLSPILP SDAAKPFSVV VFHCRHMFHK ECLPMPSMNS AAQFCNICSA
       850
KNRGPGSAIL EMKK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49754-1-unknown	MAEAEE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49754-1-unknown	MAEAEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94274
P49754-1-unknown	MAEAEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94275
P49754-51-unknown	MTVHDK...	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407835
P49754-51-unknown	MTVHDK...	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398584
P49754-51-unknown	MTVHDK...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196148
P49754-51-unknown	MTVHDK...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196149
P49754-321-unknown	ALTVRG...	321	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11601
P49754-321-unknown	ALTVRG...	321	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149767
P49754-321-unknown	ALTVRG...	321	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150355
P49754-660-unknown	LSRMGN...	660	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395410
P49754-660-unknown	LSRMGN...	660	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200113
P49754-660-unknown	LSRMGN...	660	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200114

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...FHETFD	123	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000398584
...FHETFD	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154655
...WANNMG	190	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411919
...WANNMG	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155527
...WANNMG	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155528
...DNVTLI	230	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412974
...EISSDA	320	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11601
...EISSDA	320	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133156
...EISSDA	320	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133752
...LEMKK	854	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LEMKK	854	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89893
...LEMKK	854		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LEMKK	854		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	320	SSDA.\|.ALTV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)