P49810: Presenilin-2

General Information

Protein names	- Presenilin-2 - PS-2 - 3.4.23.- - AD3LP - AD5 - E5-1 - STM-2 - Presenilin-2 NTF subunit - Presenilin-2 CTF subunit
Gene names	PSEN2
Organism	Homo sapiens
Protease Family
Protease ID	A22.002
Chromosome location
UniProt ID	P49810

5 N-termini

4 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Presenilin-2 - Isoform 3 of Presenilin-2

Sequence View

        10         20         30         40         50         60
MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGPED GENTAQWRSQ ENEEDGEEDP
        70         80         90        100        110        120
DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI
       130        140        150        160        170        180
YTPFTEDTPS VGQRLLNSVL NTLIMISVIV VMTIFLVVLY KYRCYKFIHG WLIMSSLMLL
       190        200        210        220        230        240
FLFTYIYLGE VLKTYNVAMD YPTLLLTVWN FGAVGMVCIH WKGPLVLQQA YLIMISALMA
       250        260        270        280        290        300
LVFIKYLPEW SAWVILGAIS VYDLVAVLCP KGPLRMLVET AQERNEPIFP ALIYSSAMVW
       310        320        330        340        350        360
TVGMAKLDPS SQGALQLPYD PEMEEDSYDS FGEPSYPEVF EPPLTGYPGE ELEEEEERGV
       370        380        390        400        410        420
KLGLGDFIFY SVLVGKAAAT GSGDWNTTLA CFVAILIGLC LTLLLLAVFK KALPALPISI
       430        440
TFGLIFYFST DNLVRPFMDT LASHQLYI         10         20         30         40         50         60
MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGPED GENTAQWRSQ ENEEDGEEDP
        70         80         90        100        110        120
DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI
       130        140        150        160        170        180
YTPFTEDTPS VGQRLLNSVL NTLIMISVIV VMTIFLVVLY KYRCYKFIHG WLIMSSLMLL
       190        200        210        220        230        240
FLFTYIYLGE VLKTYNVAMD YPTLLLTVWN FGAVGMVCIH WKGPLVLQQA YLIMISALMA
       250        260        270        280        290        300
LVFIKYLPEW SAWVILGAIS VYDLVAVLCP KGPLRMLVET AQERNEPIFP ALIYSSAMVW
       310        320        330        340        350        360
TVGMAKLDPS SQGALQLPYD PEMEEDSYDS FGEPSYPEVF EPPLTGYPGE ELEEEEERGV
       370        380        390        400        410        420
KLGLGDFIFY SVLVGKAAAT GSGDWNTTLA CFVAILIGLC LTLLLLAVFK KALPALPISI
       430        440
TFGLIFYFST DNLVRPFMDT LASHQLYI

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49810-1-unknown	MLTFMA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49810-1-unknown	MLTFMA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86420
P49810-1-unknown	MLTFMA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86421
P49810-298-unknown	MVWTVG...	298	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49810-298-unknown	MVWTVG...	298	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116130
P49810-298-unknown	MVWTVG...	298	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116129
P49810-298-unknown	MVWTVG...	298	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P49810-327-unknown	SYDSFG...	327	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3083
P49810-327-unknown	SYDSFG...	327	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2574
P49810-327-unknown	SYDSFG...	327	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1891
P49810-327-unknown	SYDSFG...	327	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149665
P49810-327-unknown	SYDSFG...	327	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198791
P49810-330-	SFGEPS...	330		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49810-330-unknown	SFGEPS...	330	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2865
P49810-330-unknown	SFGEPS...	330	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1231
P49810-330-unknown	SFGEPS...	330	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149761
P49810-330-unknown	SFGEPS...	330	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175910

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IYSSAM	297	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IYSSAM	297	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92273
...EMEEDS	326	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3083
...EMEEDS	326	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2574
...EMEEDS	326	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1891
...EMEEDS	326	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133053
...EDSYDS	329	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2865
...EDSYDS	329	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1231
...EDSYDS	329	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133150
...HQLYI	448	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HQLYI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82038
...HQLYI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82039

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	326	EEDS.\|.SYDS	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP6_HUMAN	326	EEDS.\|.SYDS	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP3_HUMAN	326	EEDS.\|.SYDS	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP7_HUMAN	329	SYDS.\|.SFGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP1_HUMAN	329	SYDS.\|.SFGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)