P49840: Glycogen synthase kinase-3 alpha

General Information

Protein names	- Glycogen synthase kinase-3 alpha - GSK-3 alpha - 2.7.11.26 - Serine/threonine-protein kinase GSK3A - 2.7.11.1 {ECO:0000269\|PubMed:22539723}
Gene names	GSK3A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49840

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV
        70         80         90        100        110        120
GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT
       130        140        150        160        170        180
DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY
       190        200        210        220        230        240
SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV
       250        260        270        280        290        300
CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS
       310        320        330        340        350        360
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK
       370        380        390        400        410        420
AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP
       430        440        450        460        470        480
PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTPSSQA LTETPTSSDW QSTDATPTLT

NSS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49840-2-unknown	MSGGGP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49840-2-Acetylation	SGGGPS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49840-2-Acetylation	SGGGPS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49840-23-	AEPGGG...	23			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49840-23-unknown	AEPGGG...	23			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49840-256-unknown	TAVLKL...	256		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11607

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LVDPDT	255	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11607
	...LTNSS	483	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	255	DPDT.\|.TAVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)