P49914: 5-formyltetrahydrofolate cyclo-ligase

General Information

Protein names	- 5-formyltetrahydrofolate cyclo-ligase - 6.3.3.2 - 5,10-methenyl-tetrahydrofolate synthetase - MTHFS - Methenyl-THF synthetase
Gene names	MTHFS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49914

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAVSSAK RSLRGELKQR LRAMSAEERL RQSRVLSQKV IAHSEYQKSK RISIFLSMQD
        70         80         90        100        110        120
EIETEEIIKD IFQRGKICFI PRYRFQSNHM DMVRIESPEE ISLLPKTSWN IPQPGEGDVR
       130        140        150        160        170        180
EEALSTGGLD LIFMPGLGFD KHGNRLGRGK GYYDAYLKRC LQHQEVKPYT LALAFKEQIC
       190        200
LQVPVNENDM KVDEVLYEDS STA

Isoforms

- Isoform 2 of 5-formyltetrahydrofolate cyclo-ligase

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49914-2-unknown	MAAAAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49914-2-Acetylation	AAAAVS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49914-2-Acetylation	AAAAVS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49914-2-Acetylation	AAAAVS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49914-2-Acetylation	AAAAVS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...DSSTA	203	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...DSSTA	203	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt77353

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)