P49935: Pro-cathepsin H

General Information

Protein names	- Pro-cathepsin H - Cathepsin B3 - Cathepsin BA - Cathepsin H mini chain - Cathepsin H - 3.4.22.16 - Cathepsin H heavy chain - Cathepsin H light chain
Gene names	Ctsh
Organism	Mus musculus
Protease Family	C01.040
Protease ID	C01.040
Chromosome location
UniProt ID	P49935

4 N-termini

5 C-termini

0 Cleavages

4 Substrates

Sequence

        10         20         30         40         50         60
MWAALPLLCA GAWLLSTGAT AELTVNAIEK FHFKSWMKQH QKTYSSVEYN HRLQMFANNW
        70         80         90        100        110        120
RKIQAHNQRN HTFKMALNQF SDMSFAEIKH KFLWSEPQNC SATKSNYLRG TGPYPSSMDW
       130        140        150        160        170        180
RKKGNVVSPV KNQGACGSCW TFSTTGALES AVAIASGKML SLAEQQLVDC AQAFNNHGCK
       190        200        210        220        230        240
GGLPSQAFEY ILYNKGIMEE DSYPYIGKDS SCRFNPQKAV AFVKNVVNIT LNDEAAMVEA
       250        260        270        280        290        300
VALYNPVSFA FEVTEDFLMY KSGVYSSKSC HKTPDKVNHA VLAVGYGEQN GLLYWIVKNS
       310        320        330
WGSQWGENGY FLIERGKNMC GLAACASYPI PQV

Isoforms

Sequence View

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Directness:

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 0 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49935-21-unknown	AELTVN...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49935-96-unknown	EPQNCS...	96	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49935-114-unknown	YPSSMD...	114	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49935-291-unknown	GLLYWI...	291	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49935-291-unknown	GLLYWI...	291	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NCSATK	103	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KGNVVS	127	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000114427
...VDCAQA	172	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000117599
...YGEQNG	290	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PIPQV	333	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
BID_MOUSE	6	EVSN.\|.NGSG	inferred from experiment	unknown	MEROPS	Turk B	Cirman T et al.:Selective disruption of lysosom... (C01.040)	14581476,
BID_MOUSE	12	GLGA.\|.AEHI	inferred from experiment	unknown	MEROPS	Turk B	Cirman T et al.:Selective disruption of lysosom... (C01.040)	14581476,
BID_MOUSE	47	QAYW.\|.WEAD	inferred from experiment	unknown	MEROPS	Turk B	Cirman T et al.:Selective disruption of lysosom... (C01.040)	14581476,
BID_MOUSE	71	QGRI.\|.IEPD	inferred from experiment	unknown	MEROPS	Turk B	Cirman T et al.:Selective disruption of lysosom... (C01.040)	14581476,