P49959: Double-strand break repair protein MRE11

General Information

Protein names	- Double-strand break repair protein MRE11 - 3.1.-.- {ECO:0000269\|PubMed:29670289} - Double-strand break repair protein MRE11A - Meiotic recombination 11 homolog 1 - MRE11 homolog 1 - Meiotic recombination 11 homolog A - MRE11 homolog A
Gene names	MRE11A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49959

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Double-strand break repair protein MRE11A - Isoform 2 of Double-strand break repair protein MRE11 - Isoform 3 of Double-strand break repair protein MRE11

Sequence View

        10         20         30         40         50         60
MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD
        70         80         90        100        110        120
LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI
       130        140        150        160        170        180
PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG
       190        200        210        220        230        240
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL
       250        260        270        280        290        300
VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP
       310        320        330        340        350        360
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK
       370        380        390        400        410        420
PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK
       430        440        450        460        470        480
PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK
       490        500        510        520        530        540
TQRFLKERHI DALEDKIDEE VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF
       550        560        570        580        590        600
SADDLMSIDL AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRADTGLE
       610        620        630        640        650        660
TSTRSRNSKT AVSASRNMSI IDAFKSTRQQ PSRNVTTKNY SEVIEVDESD VEEDIFPTTS
       670        680        690        700
KTDQRWSSTS SSKIMSQSQV SKGVDFESSE DDDDDPFMNT SSLRRNRR         10         20         30         40         50         60
MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD
        70         80         90        100        110        120
LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI
       130        140        150        160        170        180
PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG
       190        200        210        220        230        240
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL
       250        260        270        280        290        300
VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP
       310        320        330        340        350        360
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK
       370        380        390        400        410        420
PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK
       430        440        450        460        470        480
PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK
       490        500        510        520        530        540
TQRFLKERHI DALEDKIDEE VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF
       550        560        570        580        590        600
SADDLMSIDL AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRADTGLE
       610        620        630        640        650        660
TSTRSRNSKT AVSASRNMSI IDAFKSTRQQ PSRNVTTKNY SEVIEVDESD VEEDIFPTTS
       670        680        690        700
KTDQRWSSTS SSKIMSQSQV SKGVDFESSE DDDDDPFMNT SSLRRNRR         10         20         30         40         50         60
MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD
        70         80         90        100        110        120
LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI
       130        140        150        160        170        180
PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG
       190        200        210        220        230        240
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL
       250        260        270        280        290        300
VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP
       310        320        330        340        350        360
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK
       370        380        390        400        410        420
PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK
       430        440        450        460        470        480
PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK
       490        500        510        520        530        540
TQRFLKERHI DALEDKIDEE VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF
       550        560        570        580        590        600
SADDLMSIDL AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRADTGLE
       610        620        630        640        650        660
TSTRSRNSKT AVSASRNMSI IDAFKSTRQQ PSRNVTTKNY SEVIEVDESD VEEDIFPTTS
       670        680        690        700
KTDQRWSSTS SSKIMSQSQV SKGVDFESSE DDDDDPFMNT SSLRRNRR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P49959-2-unknown	MSTADA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49959-1-unknown	MSTADA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81519
P49959-2-Acetylation	STADAL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49959-2-Acetylation	STADAL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P49959-2-Acetylation	STADAL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110237
P49959-544-unknown	DLMSID...	544		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11610
P49959-544-unknown	DLMSID...	544		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153922
P49959-648-unknown	ESDVEE...	648		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11612
P49959-648-unknown	ESDVEE...	648		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154916

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AFSADD	543	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11610
...AFSADD	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137344
...VIEVDE	647	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11612
...VIEVDE	647	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138343
...RRNRR	708	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RRNRR	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77137

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	543	SADD.\|.DLMS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	647	EVDE.\|.ESDV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)