P51617: Interleukin-1 receptor-associated kinase 1

General Information

Protein names	- Interleukin-1 receptor-associated kinase 1 - IRAK-1 - 2.7.11.1
Gene names	IRAK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51617

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Interleukin-1 receptor-associated kinase 1 - Isoform 3 of Interleukin-1 receptor-associated kinase 1 - Isoform 4 of Interleukin-1 receptor-associated kinase 1

Sequence View

        10         20         30         40         50         60
MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE
        70         80         90        100        110        120
RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPLPS PGTTAPRPSS
       130        140        150        160        170        180
IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK
       190        200        210        220        230        240
PGPESSVSLL QGARPFPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR
       250        260        270        280        290        300
LKENADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL
       310        320        330        340        350        360
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG
       370        380        390        400        410        420
LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG
       430        440        450        460        470        480
QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLQAGL AADAWAAPIA MQIYKKHLDP
       490        500        510        520        530        540
RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP
       550        560        570        580        590        600
SPQENSYVSS TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR
       610        620        630        640        650        660
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI
       670        680        690        700        710
IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS         10         20         30         40         50         60
MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE
        70         80         90        100        110        120
RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPLPS PGTTAPRPSS
       130        140        150        160        170        180
IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK
       190        200        210        220        230        240
PGPESSVSLL QGARPFPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR
       250        260        270        280        290        300
LKENADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL
       310        320        330        340        350        360
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG
       370        380        390        400        410        420
LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG
       430        440        450        460        470        480
QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLQAGL AADAWAAPIA MQIYKKHLDP
       490        500        510        520        530        540
RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP
       550        560        570        580        590        600
SPQENSYVSS TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR
       610        620        630        640        650        660
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI
       670        680        690        700        710
IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS         10         20         30         40         50         60
MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE
        70         80         90        100        110        120
RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPLPS PGTTAPRPSS
       130        140        150        160        170        180
IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK
       190        200        210        220        230        240
PGPESSVSLL QGARPFPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR
       250        260        270        280        290        300
LKENADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL
       310        320        330        340        350        360
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG
       370        380        390        400        410        420
LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG
       430        440        450        460        470        480
QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLQAGL AADAWAAPIA MQIYKKHLDP
       490        500        510        520        530        540
RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP
       550        560        570        580        590        600
SPQENSYVSS TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR
       610        620        630        640        650        660
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI
       670        680        690        700        710
IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P51617-1-unknown	MAGGPG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P51617-1-unknown	MAGGPG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78061
P51617-1-unknown	MAGGPG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78062
P51617-1-unknown	MAGGPG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78063
P51617-565-unknown	AAPSGA...	565	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14187
P51617-565-unknown	AAPSGA...	565	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153262
P51617-565-unknown	AAPSGA...	565	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153819
P51617-565-unknown	AAPSGA...	565	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153951

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PWQPLA	564	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14187
...PWQPLA	564	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136686
...PWQPLA	564	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137241
...PWQPLA	564	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137373
...DEFQS	712	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DEFQS	712	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73681
...DEFQS	712	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73679
...DEFQS	712	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73680

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	564	QPLA.\|.AAPS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)