TopFIND 4.0

P51649: Succinate-semialdehyde dehydrogenase, mitochondrial

General Information

Protein names
- Succinate-semialdehyde dehydrogenase, mitochondrial
- 1.2.1.24
- Aldehyde dehydrogenase family 5 member A1
- NAD(+)-dependent succinic semialdehyde dehydrogenase
Gene names ALDH5A1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P51649

4

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGR LAGLSAALLR 
        70         80         90        100        110        120 
TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC RWREVSAKER 
       130        140        150        160        170        180 
SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIH 
       190        200        210        220        230        240 
TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL 
       250        260        270        280        290        300 
AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV 
       310        320        330        340        350        360 
KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF 
       370        380        390        400        410        420 
AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATVVTGG KRHQLGKNFF 
       430        440        450        460        470        480 
EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR 
       490        500        510        520        530    
VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL

Isoforms

- Isoform 2 of Succinate-semialdehyde dehydrogenase, mitochondrial

Sequence View

        10         20         30         40         50         60 
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGR LAGLSAALLR 
        70         80         90        100        110        120 
TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC RWREVSAKER 
       130        140        150        160        170        180 
SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIH 
       190        200        210        220        230        240 
TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL 
       250        260        270        280        290        300 
AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV 
       310        320        330        340        350        360 
KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF 
       370        380        390        400        410        420 
AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATVVTGG KRHQLGKNFF 
       430        440        450        460        470        480 
EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR 
       490        500        510        520        530    
VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL



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Evidence Names:


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Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...CYGGL 535 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...CYGGL 535 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt86376

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)