P51659: Peroxisomal multifunctional enzyme type 2

General Information

Protein names	- Peroxisomal multifunctional enzyme type 2 - MFE-2 - 17-beta-hydroxysteroid dehydrogenase 4 - 17-beta-HSD 4 - D-bifunctional protein - DBP - Multifunctional protein 2 - MPF-2 - Short chain dehydrogenase/reductase family 8C member 1 - (3R)-hydroxyacyl-CoA dehydrogenase - 1.1.1.n12 - Enoyl-CoA hydratase 2 - 4.2.1.107 - 4.2.1.119 - 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase
Gene names	HSD17B4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51659

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Peroxisomal multifunctional enzyme type 2 - Isoform 3 of Peroxisomal multifunctional enzyme type 2

Sequence View

        10         20         30         40         50         60
MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE
        70         80         90        100        110        120
EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH
       130        140        150        160        170        180
RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI
       190        200        210        220        230        240
EGRKSNIHCN TIAPNAGSRM TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG
       250        260        270        280        290        300
AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS
       310        320        330        340        350        360
KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD
       370        380        390        400        410        420
LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA
       430        440        450        460        470        480
GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV
       490        500        510        520        530        540
AVAIPNRPPD AVLTDTTSLN QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS
       550        560        570        580        590        600
ARRVLQQFAD NDVSRFKAIK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN
       610        620        630        640        650        660
AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI
       670        680        690        700        710        720
GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL GKLDPQKAFF SGRLKARGNI
       730
MLSQKLQMIL KDYAKL         10         20         30         40         50         60
MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE
        70         80         90        100        110        120
EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH
       130        140        150        160        170        180
RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI
       190        200        210        220        230        240
EGRKSNIHCN TIAPNAGSRM TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG
       250        260        270        280        290        300
AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS
       310        320        330        340        350        360
KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD
       370        380        390        400        410        420
LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA
       430        440        450        460        470        480
GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV
       490        500        510        520        530        540
AVAIPNRPPD AVLTDTTSLN QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS
       550        560        570        580        590        600
ARRVLQQFAD NDVSRFKAIK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN
       610        620        630        640        650        660
AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI
       670        680        690        700        710        720
GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL GKLDPQKAFF SGRLKARGNI
       730
MLSQKLQMIL KDYAKL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P51659-1-unknown	MGSPLR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51659-69-unknown	AVANYD...	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178170
P51659-69-unknown	AVANYD...	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178171
P51659-69-unknown	AVANYD...	69	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51659-69-unknown	AVANYD...	69	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P51659-69-	AVANYD...	69		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P51659-291-unknown	STGSII...	291	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17703
P51659-291-unknown	STGSII...	291	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149184
P51659-291-unknown	STGSII...	291	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150236
P51659-312-unknown	HTSRAT...	312	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51659-312-unknown	HTSRAT...	312	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116143
P51659-312-unknown	HTSRAT...	312	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116144

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QSIQES	290	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17703
...QSIQES	290	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132569
...QSIQES	290	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133629
...GVSANH	311	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GVSANH	311	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92346
...GVSANH	311	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92347
...DYAKL	736	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DYAKL	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68318
...DYAKL	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68317

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	290	IQES.\|.STGS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)