P51798: H(+)/Cl(-) exchange transporter 7

General Information

Protein names	- H(+)/Cl(-) exchange transporter 7 - Chloride channel 7 alpha subunit - Chloride channel protein 7 - ClC-7
Gene names	CLCN7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51798

2 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MANVSKKVSW SGRDRDDEEA APLLRRTARP GGGTPLLNGA GPGAARQSPR SALFRVGHMS
        70         80         90        100        110        120
SVELDDELLD PDMDPPHPFP KEIPHNEKLL SLKYESLDYD NSENQLFLEE ERRINHTAFR
       130        140        150        160        170        180
TVEIKRWVIC ALIGILTGLV ACFIDIVVEN LAGLKYRVIK GNIDKFTEKG GLSFSLLLWA
       190        200        210        220        230        240
TLNAAFVLVG SVIVAFIEPV AAGSGIPQIK CFLNGVKIPH VVRLKTLVIK VSGVILSVVG
       250        260        270        280        290        300
GLAVGKEGPM IHSGSVIAAG ISQGRSTSLK RDFKIFEYFR RDTEKRDFVS AGAAAGVSAA
       310        320        330        340        350        360
FGAPVGGVLF SLEEGASFWN QFLTWRIFFA SMISTFTLNF VLSIYHGNMW DLSSPGLINF
       370        380        390        400        410        420
GRFDSEKMAY TIHEIPVFIA MGVVGGVLGA VFNALNYWLT MFRIRYIHRP CLQVIEAVLV
       430        440        450        460        470        480
AAVTATVAFV LIYSSRDCQP LQGGSMSYPL QLFCADGEYN SMAAAFFNTP EKSVVSLFHD
       490        500        510        520        530        540
PPGSYNPLTL GLFTLVYFFL ACWTYGLTVS AGVFIPSLLI GAAWGRLFGI SLSYLTGAAI
       550        560        570        580        590        600
WADPGKYALM GAAAQLGGIV RMTLSLTVIM MEATSNVTYG FPIMLVLMTA KIVGDVFIEG
       610        620        630        640        650        660
LYDMHIQLQS VPFLHWEAPV TSHSLTAREV MSTPVTCLRR REKVGVIVDV LSDTASNHNG
       670        680        690        700        710        720
FPVVEHADDT QPARLQGLIL RSQLIVLLKH KVFVERSNLG LVQRRLRLKD FRDAYPRFPP
       730        740        750        760        770        780
IQSIHVSQDE RECTMDLSEF MNPSPYTVPQ EASLPRVFKL FRALGLRHLV VVDNRNQVVG
       790        800
LVTRKDLARY RLGKRGLEEL SLAQT

Isoforms

- Isoform 2 of H(+)/Cl(-) exchange transporter 7

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P51798-1-unknown	MANVSK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P51798-1-unknown	MANVSK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70935
P51798-121-unknown	TVEIKR...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11644
P51798-121-unknown	TVEIKR...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142249

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HTAFRT	120	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11644
...HTAFRT	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125438
...SLAQT	805		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SLAQT	805		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SLAQT	805	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SLAQT	805	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66553
...SLAQT	805		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SLAQT	805		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	120	AFRT.\|.TVEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)