P51812: Ribosomal protein S6 kinase alpha-3

General Information

Protein names	- Ribosomal protein S6 kinase alpha-3 - S6K-alpha-3 - 2.7.11.1 {ECO:0000269\|PubMed:17213202} - 90 kDa ribosomal protein S6 kinase 3 - p90-RSK 3 - p90RSK3 - Insulin-stimulated protein kinase 1 - ISPK-1 - MAP kinase-activated protein kinase 1b - MAPK-activated protein kinase 1b - MAPKAP kinase 1b - MAPKAPK-1b - Ribosomal S6 kinase 2 - RSK-2 - pp90RSK2
Gene names	RPS6KA3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51812

3 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEVSIKEI AITHHVKEGH
        70         80         90        100        110        120
EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD
       130        140        150        160        170        180
ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA
       190        200        210        220        230        240
LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV
       250        260        270        280        290        300
NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR
       310        320        330        340        350        360
MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE
       370        380        390        400        410        420
FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD
       430        440        450        460        470        480
GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK
       490        500        510        520        530        540
DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL
       550        560        570        580        590        600
KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD
       610        620        630        640        650        660
IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML
       670        680        690        700        710        720
HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP
       730        740
VGRSTLAQRR GIKKITSTAL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P51812-1-unknown	MPLAQL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51812-29-unknown	MDEPMG...	29		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388512
P51812-29-unknown	MDEPMG...	29		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440220
P51812-29-unknown	MDEPMG...	29		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444837
P51812-713-acetylation	NQSPVL...	713	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...TRLSKE	161	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388512
...WSFGVL	256	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407655
...TSTAL	740	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TSTAL	740		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TSTAL	740		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...TSTAL	740		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TSTAL	740		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)