P52948: Nuclear pore complex protein Nup98-Nup96

General Information

Protein names	- Nuclear pore complex protein Nup98-Nup96 - 3.4.21.- {ECO:0000269\|PubMed:12191480, ECO:0000269\|PubMed:18287282} - Nuclear pore complex protein Nup98 - 98 kDa nucleoporin - Nucleoporin Nup98 - Nup98 - Nuclear pore complex protein Nup96 - 96 kDa nucleoporin - Nucleoporin Nup96 - Nup96
Gene names	NUP98
Organism	Homo sapiens
Protease Family	S59.001
Protease ID	S59.001
Chromosome location
UniProt ID	P52948

8 N-termini

2 C-termini

1 Cleavages

6 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear pore complex protein Nup98-Nup96 - Isoform 3 of Nuclear pore complex protein Nup98-Nup96 - Isoform 4 of Nuclear pore complex protein Nup98-Nup96 - Isoform 5 of Nuclear pore complex protein Nup98-Nup96 - Isoform 6 of Nuclear pore complex protein Nup98-Nup96

Sequence View

        10         20         30         40         50         60
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG
        70         80         90        100        110        120
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF
       130        140        150        160        170        180
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST
       190        200        210        220        230        240
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL
       250        260        270        280        290        300
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF
       310        320        330        340        350        360
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV
       370        380        390        400        410        420
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF
       430        440        450        460        470        480
GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG
       490        500        510        520        530        540
APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA
       550        560        570        580        590        600
QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL
       610        620        630        640        650        660
VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT
       670        680        690        700        710        720
NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE
       730        740        750        760        770        780
EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD
       790        800        810        820        830        840
VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP
       850        860        870        880        890        900
DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS
       910        920        930        940        950        960
TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD
       970        980        990       1000       1010       1020
TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA
      1030       1040       1050       1060       1070       1080
DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP
      1090       1100       1110       1120       1130       1140
STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG
      1150       1160       1170       1180       1190       1200
RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK
      1210       1220       1230       1240       1250       1260
LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL
      1270       1280       1290       1300       1310       1320
PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE
      1330       1340       1350       1360       1370       1380
EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV
      1390       1400       1410       1420       1430       1440
DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA
      1450       1460       1470       1480       1490       1500
SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS
      1510       1520       1530       1540       1550       1560
DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG
      1570       1580       1590       1600       1610       1620
LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK
      1630       1640       1650       1660       1670       1680
AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS
      1690       1700       1710       1720       1730       1740
SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD
      1750       1760       1770       1780       1790       1800
RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE
      1810
LRSLTQSYLR ELAVGSL         10         20         30         40         50         60
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG
        70         80         90        100        110        120
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF
       130        140        150        160        170        180
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST
       190        200        210        220        230        240
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL
       250        260        270        280        290        300
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF
       310        320        330        340        350        360
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV
       370        380        390        400        410        420
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF
       430        440        450        460        470        480
GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG
       490        500        510        520        530        540
APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA
       550        560        570        580        590        600
QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL
       610        620        630        640        650        660
VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT
       670        680        690        700        710        720
NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE
       730        740        750        760        770        780
EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD
       790        800        810        820        830        840
VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP
       850        860        870        880        890        900
DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS
       910        920        930        940        950        960
TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD
       970        980        990       1000       1010       1020
TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA
      1030       1040       1050       1060       1070       1080
DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP
      1090       1100       1110       1120       1130       1140
STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG
      1150       1160       1170       1180       1190       1200
RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK
      1210       1220       1230       1240       1250       1260
LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL
      1270       1280       1290       1300       1310       1320
PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE
      1330       1340       1350       1360       1370       1380
EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV
      1390       1400       1410       1420       1430       1440
DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA
      1450       1460       1470       1480       1490       1500
SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS
      1510       1520       1530       1540       1550       1560
DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG
      1570       1580       1590       1600       1610       1620
LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK
      1630       1640       1650       1660       1670       1680
AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS
      1690       1700       1710       1720       1730       1740
SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD
      1750       1760       1770       1780       1790       1800
RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE
      1810
LRSLTQSYLR ELAVGSL         10         20         30         40         50         60
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG
        70         80         90        100        110        120
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF
       130        140        150        160        170        180
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST
       190        200        210        220        230        240
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL
       250        260        270        280        290        300
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF
       310        320        330        340        350        360
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV
       370        380        390        400        410        420
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF
       430        440        450        460        470        480
GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG
       490        500        510        520        530        540
APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA
       550        560        570        580        590        600
QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL
       610        620        630        640        650        660
VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT
       670        680        690        700        710        720
NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE
       730        740        750        760        770        780
EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD
       790        800        810        820        830        840
VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP
       850        860        870        880        890        900
DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS
       910        920        930        940        950        960
TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD
       970        980        990       1000       1010       1020
TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA
      1030       1040       1050       1060       1070       1080
DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP
      1090       1100       1110       1120       1130       1140
STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG
      1150       1160       1170       1180       1190       1200
RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK
      1210       1220       1230       1240       1250       1260
LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL
      1270       1280       1290       1300       1310       1320
PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE
      1330       1340       1350       1360       1370       1380
EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV
      1390       1400       1410       1420       1430       1440
DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA
      1450       1460       1470       1480       1490       1500
SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS
      1510       1520       1530       1540       1550       1560
DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG
      1570       1580       1590       1600       1610       1620
LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK
      1630       1640       1650       1660       1670       1680
AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS
      1690       1700       1710       1720       1730       1740
SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD
      1750       1760       1770       1780       1790       1800
RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE
      1810
LRSLTQSYLR ELAVGSL         10         20         30         40         50         60
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG
        70         80         90        100        110        120
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF
       130        140        150        160        170        180
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST
       190        200        210        220        230        240
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL
       250        260        270        280        290        300
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF
       310        320        330        340        350        360
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV
       370        380        390        400        410        420
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF
       430        440        450        460        470        480
GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG
       490        500        510        520        530        540
APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA
       550        560        570        580        590        600
QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL
       610        620        630        640        650        660
VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT
       670        680        690        700        710        720
NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE
       730        740        750        760        770        780
EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD
       790        800        810        820        830        840
VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP
       850        860        870        880        890        900
DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS
       910        920        930        940        950        960
TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD
       970        980        990       1000       1010       1020
TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA
      1030       1040       1050       1060       1070       1080
DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP
      1090       1100       1110       1120       1130       1140
STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG
      1150       1160       1170       1180       1190       1200
RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK
      1210       1220       1230       1240       1250       1260
LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL
      1270       1280       1290       1300       1310       1320
PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE
      1330       1340       1350       1360       1370       1380
EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV
      1390       1400       1410       1420       1430       1440
DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA
      1450       1460       1470       1480       1490       1500
SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS
      1510       1520       1530       1540       1550       1560
DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG
      1570       1580       1590       1600       1610       1620
LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK
      1630       1640       1650       1660       1670       1680
AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS
      1690       1700       1710       1720       1730       1740
SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD
      1750       1760       1770       1780       1790       1800
RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE
      1810
LRSLTQSYLR ELAVGSL         10         20         30         40         50         60
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG
        70         80         90        100        110        120
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF
       130        140        150        160        170        180
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST
       190        200        210        220        230        240
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL
       250        260        270        280        290        300
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF
       310        320        330        340        350        360
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV
       370        380        390        400        410        420
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNTSGNSIF
       430        440        450        460        470        480
GSKPAPGTLG TGLGAGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTTTATLGFG
       490        500        510        520        530        540
APQAPVALTD PNASAAQQAV LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA
       550        560        570        580        590        600
QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL
       610        620        630        640        650        660
VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD EDSLVSHFYT
       670        680        690        700        710        720
NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE
       730        740        750        760        770        780
EIENNSYHMH PAGIILTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD
       790        800        810        820        830        840
VNLTNLNLDD IVHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP
       850        860        870        880        890        900
DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS
       910        920        930        940        950        960
TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD
       970        980        990       1000       1010       1020
TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT DEEDVDMALD QRFSRLPSKA
      1030       1040       1050       1060       1070       1080
DTSQEICSPR LPISASHSSK TRSLVGGLLQ SKFTSGAFLS PSVSVQECRT PRAASLMNIP
      1090       1100       1110       1120       1130       1140
STSSWSVPPP LTSVFTMPSP APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG
      1150       1160       1170       1180       1190       1200
RSFRVGWGPN WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK
      1210       1220       1230       1240       1250       1260
LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA DWVKEASGDL
      1270       1280       1290       1300       1310       1320
PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL ERRRAFSRWL SCTATPQIEE
      1330       1340       1350       1360       1370       1380
EVSLTQKNSP VEAVFSYLTG KRISEACSLA QQSGDHRLAL LLSQFVGSQS VRELLTMQLV
      1390       1400       1410       1420       1430       1440
DWHQLQADSF IQDERLRIFA LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA
      1450       1460       1470       1480       1490       1500
SISRALSMYE EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS
      1510       1520       1530       1540       1550       1560
DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA SYAGQLESEG
      1570       1580       1590       1600       1610       1620
LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA KETFLTQKLR VPAKWIHEAK
      1630       1640       1650       1660       1670       1680
AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII NENYDYLKGF LEDLAPPERS
      1690       1700       1710       1720       1730       1740
SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD
      1750       1760       1770       1780       1790       1800
RLAQSDMAKR VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE
      1810
LRSLTQSYLR ELAVGSL

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Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 6 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52948-1-unknown	MFNKSF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52948-1-unknown	MFNKSF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83552
P52948-1-unknown	MFNKSF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83553
P52948-1-unknown	MFNKSF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83554
P52948-1-unknown	MFNKSF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83555
P52948-1-unknown	MFNKSF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83556
P52948-683-	SVDDTI...	683		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52948-683-unknown	SVDDTI...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176560
P52948-683-unknown	SVDDTI...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176561
P52948-683-unknown	SVDDTI...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176563
P52948-683-unknown	SVDDTI...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176559
P52948-683-unknown	SVDDTI...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176562
P52948-881-unknown	SKYGLQ...	881	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52948-881-unknown	SKYGLQ...	881	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26775
P52948-881-unknown	SKYGLQ...	881	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116386
P52948-881-unknown	SKYGLQ...	881	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116387
P52948-881-unknown	SKYGLQ...	881	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116389
P52948-881-unknown	SKYGLQ...	881	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116385
P52948-881-unknown	SKYGLQ...	881	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116388
P52948-884-	GLQDSD...	884		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P52948-884-unknown	GLQDSD...	884	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164467
P52948-884-unknown	GLQDSD...	884	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164468
P52948-884-unknown	GLQDSD...	884	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164470
P52948-884-unknown	GLQDSD...	884	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164466
P52948-884-unknown	GLQDSD...	884	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164469
P52948-1093-	SVFTMP...	1093		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52948-1093-	SVFTMP...	1093		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52948-1093-	SVFTMP...	1093		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52948-1093-unknown	SVFTMP...	1093	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168551
P52948-1093-unknown	SVFTMP...	1093	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168552

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVSHFS	880	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KVSHFS	880	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26775
...KVSHFS	880	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93474
...KVSHFS	880	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93475
...KVSHFS	880	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93477
...KVSHFS	880	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93473
...KVSHFS	880	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93476
...AVGSL	1817	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AVGSL	1817	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79174
...AVGSL	1817	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79170
...AVGSL	1817	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79173

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NUP98_HUMAN	880	SHFS.\|.SKYG	inferred from experiment	unknown	MEROPS	Powers MA	Hodel AE et al.:The three-dimensional structure... (S59.001)	12191480,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NUP98-Isoform5_HUMAN	863	SHFS.\|.SKYG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26775
NUP98-Isoform4_HUMAN	863	SHFS.\|.SKYG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26775
NUP98-Isoform2_HUMAN	863	SHFS.\|.SKYG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26775
NUP98_HUMAN	880	SHFS.\|.SKYG	inferred from experiment	unknown	MEROPS	Powers MA	Hodel AE et al.:The three-dimensional structure... (S59.001)	12191480,
NUP98-Isoform6_HUMAN	880	SHFS.\|.SKYG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26775
NUP98-Isoform3_HUMAN	880	SHFS.\|.SKYG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26775