P54277: PMS1 protein homolog 1

General Information

Protein names	- PMS1 protein homolog 1 - DNA mismatch repair protein PMS1
Gene names	PMS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54277

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of PMS1 protein homolog 1 - Isoform 3 of PMS1 protein homolog 1 - Isoform 4 of PMS1 protein homolog 1

Sequence View

        10         20         30         40         50         60
MKQLPAATVR LLSSSQIITS VVSVVKELIE NSLDAGATSV DVKLENYGFD KIEVRDNGEG
        70         80         90        100        110        120
IKAVDAPVMA MKYYTSKINS HEDLENLTTY GFRGEALGSI CCIAEVLITT RTAADNFSTQ
       130        140        150        160        170        180
YVLDGSGHIL SQKPSHLGQG TTVTALRLFK NLPVRKQFYS TAKKCKDEIK KIQDLLMSFG
       190        200        210        220        230        240
ILKPDLRIVF VHNKAVIWQK SRVSDHKMAL MSVLGTAVMN NMESFQYHSE ESQIYLSGFL
       250        260        270        280        290        300
PKCDADHSFT SLSTPERSFI FINSRPVHQK DILKLIRHHY NLKCLKESTR LYPVFFLKID
       310        320        330        340        350        360
VPTADVDVNL TPDKSQVLLQ NKESVLIALE NLMTTCYGPL PSTNSYENNK TDVSAADIVL
       370        380        390        400        410        420
SKTAETDVLF NKVESSGKNY SNVDTSVIPF QNDMHNDESG KNTDDCLNHQ ISIGDFGYGH
       430        440        450        460        470        480
CSSEISNIDK NTKNAFQDIS MSNVSWENSQ TEYSKTCFIS SVKHTQSENG NKDHIDESGE
       490        500        510        520        530        540
NEEEAGLENS SEISADEWSR GNILKNSVGE NIEPVKILVP EKSLPCKVSN NNYPIPEQMN
       550        560        570        580        590        600
LNEDSCNKKS NVIDNKSGKV TAYDLLSNRV IKKPMSASAL FVQDHRPQFL IENPKTSLED
       610        620        630        640        650        660
ATLQIEELWK TLSEEEKLKY EEKATKDLER YNSQMKRAIE QESQMSLKDG RKKIKPTSAW
       670        680        690        700        710        720
NLAQKHKLKT SLSNQPKLDE LLQSQIEKRR SQNIKMVQIP FSMKNLKINF KKQNKVDLEE
       730        740        750        760        770        780
KDEPCLIHNL RFPDAWLMTS KTEVMLLNPY RVEEALLFKR LLENHKLPAE PLEKPIMLTE
       790        800        810        820        830        840
SLFNGSHYLD VLYKMTADDQ RYSGSTYLSD PRLTANGFKI KLIPGVSITE NYLEIEGMAN
       850        860        870        880        890        900
CLPFYGVADL KEILNAILNR NAKEVYECRP RKVISYLEGE AVRLSRQLPM YLSKEDIQDI
       910        920        930
IYRMKHQFGN EIKECVHGRP FFHHLTYLPE TT         10         20         30         40         50         60
MKQLPAATVR LLSSSQIITS VVSVVKELIE NSLDAGATSV DVKLENYGFD KIEVRDNGEG
        70         80         90        100        110        120
IKAVDAPVMA MKYYTSKINS HEDLENLTTY GFRGEALGSI CCIAEVLITT RTAADNFSTQ
       130        140        150        160        170        180
YVLDGSGHIL SQKPSHLGQG TTVTALRLFK NLPVRKQFYS TAKKCKDEIK KIQDLLMSFG
       190        200        210        220        230        240
ILKPDLRIVF VHNKAVIWQK SRVSDHKMAL MSVLGTAVMN NMESFQYHSE ESQIYLSGFL
       250        260        270        280        290        300
PKCDADHSFT SLSTPERSFI FINSRPVHQK DILKLIRHHY NLKCLKESTR LYPVFFLKID
       310        320        330        340        350        360
VPTADVDVNL TPDKSQVLLQ NKESVLIALE NLMTTCYGPL PSTNSYENNK TDVSAADIVL
       370        380        390        400        410        420
SKTAETDVLF NKVESSGKNY SNVDTSVIPF QNDMHNDESG KNTDDCLNHQ ISIGDFGYGH
       430        440        450        460        470        480
CSSEISNIDK NTKNAFQDIS MSNVSWENSQ TEYSKTCFIS SVKHTQSENG NKDHIDESGE
       490        500        510        520        530        540
NEEEAGLENS SEISADEWSR GNILKNSVGE NIEPVKILVP EKSLPCKVSN NNYPIPEQMN
       550        560        570        580        590        600
LNEDSCNKKS NVIDNKSGKV TAYDLLSNRV IKKPMSASAL FVQDHRPQFL IENPKTSLED
       610        620        630        640        650        660
ATLQIEELWK TLSEEEKLKY EEKATKDLER YNSQMKRAIE QESQMSLKDG RKKIKPTSAW
       670        680        690        700        710        720
NLAQKHKLKT SLSNQPKLDE LLQSQIEKRR SQNIKMVQIP FSMKNLKINF KKQNKVDLEE
       730        740        750        760        770        780
KDEPCLIHNL RFPDAWLMTS KTEVMLLNPY RVEEALLFKR LLENHKLPAE PLEKPIMLTE
       790        800        810        820        830        840
SLFNGSHYLD VLYKMTADDQ RYSGSTYLSD PRLTANGFKI KLIPGVSITE NYLEIEGMAN
       850        860        870        880        890        900
CLPFYGVADL KEILNAILNR NAKEVYECRP RKVISYLEGE AVRLSRQLPM YLSKEDIQDI
       910        920        930
IYRMKHQFGN EIKECVHGRP FFHHLTYLPE TT         10         20         30         40         50         60
MKQLPAATVR LLSSSQIITS VVSVVKELIE NSLDAGATSV DVKLENYGFD KIEVRDNGEG
        70         80         90        100        110        120
IKAVDAPVMA MKYYTSKINS HEDLENLTTY GFRGEALGSI CCIAEVLITT RTAADNFSTQ
       130        140        150        160        170        180
YVLDGSGHIL SQKPSHLGQG TTVTALRLFK NLPVRKQFYS TAKKCKDEIK KIQDLLMSFG
       190        200        210        220        230        240
ILKPDLRIVF VHNKAVIWQK SRVSDHKMAL MSVLGTAVMN NMESFQYHSE ESQIYLSGFL
       250        260        270        280        290        300
PKCDADHSFT SLSTPERSFI FINSRPVHQK DILKLIRHHY NLKCLKESTR LYPVFFLKID
       310        320        330        340        350        360
VPTADVDVNL TPDKSQVLLQ NKESVLIALE NLMTTCYGPL PSTNSYENNK TDVSAADIVL
       370        380        390        400        410        420
SKTAETDVLF NKVESSGKNY SNVDTSVIPF QNDMHNDESG KNTDDCLNHQ ISIGDFGYGH
       430        440        450        460        470        480
CSSEISNIDK NTKNAFQDIS MSNVSWENSQ TEYSKTCFIS SVKHTQSENG NKDHIDESGE
       490        500        510        520        530        540
NEEEAGLENS SEISADEWSR GNILKNSVGE NIEPVKILVP EKSLPCKVSN NNYPIPEQMN
       550        560        570        580        590        600
LNEDSCNKKS NVIDNKSGKV TAYDLLSNRV IKKPMSASAL FVQDHRPQFL IENPKTSLED
       610        620        630        640        650        660
ATLQIEELWK TLSEEEKLKY EEKATKDLER YNSQMKRAIE QESQMSLKDG RKKIKPTSAW
       670        680        690        700        710        720
NLAQKHKLKT SLSNQPKLDE LLQSQIEKRR SQNIKMVQIP FSMKNLKINF KKQNKVDLEE
       730        740        750        760        770        780
KDEPCLIHNL RFPDAWLMTS KTEVMLLNPY RVEEALLFKR LLENHKLPAE PLEKPIMLTE
       790        800        810        820        830        840
SLFNGSHYLD VLYKMTADDQ RYSGSTYLSD PRLTANGFKI KLIPGVSITE NYLEIEGMAN
       850        860        870        880        890        900
CLPFYGVADL KEILNAILNR NAKEVYECRP RKVISYLEGE AVRLSRQLPM YLSKEDIQDI
       910        920        930
IYRMKHQFGN EIKECVHGRP FFHHLTYLPE TT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54277-1-unknown	MKQLPA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54277-1-unknown	MKQLPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85674
P54277-1-unknown	MKQLPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85675
P54277-1-unknown	MKQLPA...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P54277-1-unknown	MKQLPA...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P54277-497-unknown	EWSRGN...	497	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11679
P54277-497-unknown	EWSRGN...	497	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149402
P54277-497-unknown	EWSRGN...	497	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152886
P54277-497-unknown	EWSRGN...	497	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153385

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EISADE	496	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11679
...EISADE	496	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132787
...EISADE	496	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136311
...EISADE	496	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136810
...LPETT	932	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LPETT	932	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81294
...LPETT	932	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81292
...LPETT	932	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81293

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	496	SADE.\|.EWSR	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)