P54278: Mismatch repair endonuclease PMS2 {ECO:0000305}

General Information

Protein names	- Mismatch repair endonuclease PMS2 {ECO:0000305} - 3.1.-.- - DNA mismatch repair protein PMS2 - PMS1 protein homolog 2
Gene names	PMS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54278

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MERAESSSTE PAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSLDAG ATNIDLKLKD
        70         80         90        100        110        120
YGVDLIEVSD NGCGVEEENF EGLTLKHHTS KIQEFADLTQ VETFGFRGEA LSSLCALSDV
       130        140        150        160        170        180
TISTCHASAK VGTRLMFDHN GKIIQKTPYP RPRGTTVSVQ QLFSTLPVRH KEFQRNIKKE
       190        200        210        220        230        240
YAKMVQVLHA YCIISAGIRV SCTNQLGQGK RQPVVCTGGS PSIKENIGSV FGQKQLQSLI
       250        260        270        280        290        300
PFVQLPPSDS VCEEYGLSCS DALHNLFYIS GFISQCTHGV GRSSTDRQFF FINRRPCDPA
       310        320        330        340        350        360
KVCRLVNEVY HMYNRHQYPF VVLNISVDSE CVDINVTPDK RQILLQEEKL LLAVLKTSLI
       370        380        390        400        410        420
GMFDSDVNKL NVSQQPLLDV EGNLIKMHAA DLEKPMVEKQ DQSPSLRTGE EKKDVSISRL
       430        440        450        460        470        480
REAFSLRHTT ENKPHSPKTP EPRRSPLGQK RGMLSSSTSG AISDKGVLRP QKEAVSSSHG
       490        500        510        520        530        540
PSDPTDRAEV EKDSGHGSTS VDSEGFSIPD TGSHCSSEYA ASSPGDRGSQ EHVDSQEKAP
       550        560        570        580        590        600
KTDDSFSDVD CHSNQEDTGC KFRVLPQPTN LATPNTKRFK KEEILSSSDI CQKLVNTQDM
       610        620        630        640        650        660
SASQVDVAVK INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA
       670        680        690        700        710        720
EDELRKEISK TMFAEMEIIG QFNLGFIITK LNEDIFIVDQ HATDEKYNFE MLQQHTVLQG
       730        740        750        760        770        780
QRLIAPQTLN LTAVNEAVLI ENLEIFRKNG FDFVIDENAP VTERAKLISL PTSKNWTFGP
       790        800        810        820        830        840
QDVDELIFML SDSPGVMCRP SRVKQMFASR ACRKSVMIGT ALNTSEMKKL ITHMGEMDHP
       850        860
WNCPHGRPTM RHIANLGVIS QN

Isoforms

- Isoform 2 of Mismatch repair endonuclease PMS2 - Isoform 3 of Mismatch repair endonuclease PMS2 - Isoform 4 of Mismatch repair endonuclease PMS2

Sequence View

        10         20         30         40         50         60
MERAESSSTE PAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSLDAG ATNIDLKLKD
        70         80         90        100        110        120
YGVDLIEVSD NGCGVEEENF EGLTLKHHTS KIQEFADLTQ VETFGFRGEA LSSLCALSDV
       130        140        150        160        170        180
TISTCHASAK VGTRLMFDHN GKIIQKTPYP RPRGTTVSVQ QLFSTLPVRH KEFQRNIKKE
       190        200        210        220        230        240
YAKMVQVLHA YCIISAGIRV SCTNQLGQGK RQPVVCTGGS PSIKENIGSV FGQKQLQSLI
       250        260        270        280        290        300
PFVQLPPSDS VCEEYGLSCS DALHNLFYIS GFISQCTHGV GRSSTDRQFF FINRRPCDPA
       310        320        330        340        350        360
KVCRLVNEVY HMYNRHQYPF VVLNISVDSE CVDINVTPDK RQILLQEEKL LLAVLKTSLI
       370        380        390        400        410        420
GMFDSDVNKL NVSQQPLLDV EGNLIKMHAA DLEKPMVEKQ DQSPSLRTGE EKKDVSISRL
       430        440        450        460        470        480
REAFSLRHTT ENKPHSPKTP EPRRSPLGQK RGMLSSSTSG AISDKGVLRP QKEAVSSSHG
       490        500        510        520        530        540
PSDPTDRAEV EKDSGHGSTS VDSEGFSIPD TGSHCSSEYA ASSPGDRGSQ EHVDSQEKAP
       550        560        570        580        590        600
KTDDSFSDVD CHSNQEDTGC KFRVLPQPTN LATPNTKRFK KEEILSSSDI CQKLVNTQDM
       610        620        630        640        650        660
SASQVDVAVK INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA
       670        680        690        700        710        720
EDELRKEISK TMFAEMEIIG QFNLGFIITK LNEDIFIVDQ HATDEKYNFE MLQQHTVLQG
       730        740        750        760        770        780
QRLIAPQTLN LTAVNEAVLI ENLEIFRKNG FDFVIDENAP VTERAKLISL PTSKNWTFGP
       790        800        810        820        830        840
QDVDELIFML SDSPGVMCRP SRVKQMFASR ACRKSVMIGT ALNTSEMKKL ITHMGEMDHP
       850        860
WNCPHGRPTM RHIANLGVIS QN         10         20         30         40         50         60
MERAESSSTE PAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSLDAG ATNIDLKLKD
        70         80         90        100        110        120
YGVDLIEVSD NGCGVEEENF EGLTLKHHTS KIQEFADLTQ VETFGFRGEA LSSLCALSDV
       130        140        150        160        170        180
TISTCHASAK VGTRLMFDHN GKIIQKTPYP RPRGTTVSVQ QLFSTLPVRH KEFQRNIKKE
       190        200        210        220        230        240
YAKMVQVLHA YCIISAGIRV SCTNQLGQGK RQPVVCTGGS PSIKENIGSV FGQKQLQSLI
       250        260        270        280        290        300
PFVQLPPSDS VCEEYGLSCS DALHNLFYIS GFISQCTHGV GRSSTDRQFF FINRRPCDPA
       310        320        330        340        350        360
KVCRLVNEVY HMYNRHQYPF VVLNISVDSE CVDINVTPDK RQILLQEEKL LLAVLKTSLI
       370        380        390        400        410        420
GMFDSDVNKL NVSQQPLLDV EGNLIKMHAA DLEKPMVEKQ DQSPSLRTGE EKKDVSISRL
       430        440        450        460        470        480
REAFSLRHTT ENKPHSPKTP EPRRSPLGQK RGMLSSSTSG AISDKGVLRP QKEAVSSSHG
       490        500        510        520        530        540
PSDPTDRAEV EKDSGHGSTS VDSEGFSIPD TGSHCSSEYA ASSPGDRGSQ EHVDSQEKAP
       550        560        570        580        590        600
KTDDSFSDVD CHSNQEDTGC KFRVLPQPTN LATPNTKRFK KEEILSSSDI CQKLVNTQDM
       610        620        630        640        650        660
SASQVDVAVK INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA
       670        680        690        700        710        720
EDELRKEISK TMFAEMEIIG QFNLGFIITK LNEDIFIVDQ HATDEKYNFE MLQQHTVLQG
       730        740        750        760        770        780
QRLIAPQTLN LTAVNEAVLI ENLEIFRKNG FDFVIDENAP VTERAKLISL PTSKNWTFGP
       790        800        810        820        830        840
QDVDELIFML SDSPGVMCRP SRVKQMFASR ACRKSVMIGT ALNTSEMKKL ITHMGEMDHP
       850        860
WNCPHGRPTM RHIANLGVIS QN         10         20         30         40         50         60
MERAESSSTE PAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSLDAG ATNIDLKLKD
        70         80         90        100        110        120
YGVDLIEVSD NGCGVEEENF EGLTLKHHTS KIQEFADLTQ VETFGFRGEA LSSLCALSDV
       130        140        150        160        170        180
TISTCHASAK VGTRLMFDHN GKIIQKTPYP RPRGTTVSVQ QLFSTLPVRH KEFQRNIKKE
       190        200        210        220        230        240
YAKMVQVLHA YCIISAGIRV SCTNQLGQGK RQPVVCTGGS PSIKENIGSV FGQKQLQSLI
       250        260        270        280        290        300
PFVQLPPSDS VCEEYGLSCS DALHNLFYIS GFISQCTHGV GRSSTDRQFF FINRRPCDPA
       310        320        330        340        350        360
KVCRLVNEVY HMYNRHQYPF VVLNISVDSE CVDINVTPDK RQILLQEEKL LLAVLKTSLI
       370        380        390        400        410        420
GMFDSDVNKL NVSQQPLLDV EGNLIKMHAA DLEKPMVEKQ DQSPSLRTGE EKKDVSISRL
       430        440        450        460        470        480
REAFSLRHTT ENKPHSPKTP EPRRSPLGQK RGMLSSSTSG AISDKGVLRP QKEAVSSSHG
       490        500        510        520        530        540
PSDPTDRAEV EKDSGHGSTS VDSEGFSIPD TGSHCSSEYA ASSPGDRGSQ EHVDSQEKAP
       550        560        570        580        590        600
KTDDSFSDVD CHSNQEDTGC KFRVLPQPTN LATPNTKRFK KEEILSSSDI CQKLVNTQDM
       610        620        630        640        650        660
SASQVDVAVK INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA
       670        680        690        700        710        720
EDELRKEISK TMFAEMEIIG QFNLGFIITK LNEDIFIVDQ HATDEKYNFE MLQQHTVLQG
       730        740        750        760        770        780
QRLIAPQTLN LTAVNEAVLI ENLEIFRKNG FDFVIDENAP VTERAKLISL PTSKNWTFGP
       790        800        810        820        830        840
QDVDELIFML SDSPGVMCRP SRVKQMFASR ACRKSVMIGT ALNTSEMKKL ITHMGEMDHP
       850        860
WNCPHGRPTM RHIANLGVIS QN

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P54278-1-unknown	MERAES...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P54278-1-unknown	MERAES...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85677
P54278-1-unknown	MERAES...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85678
P54278-1-unknown	MERAES...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85679
P54278-495-unknown	GHGSTS...	495	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11683
P54278-495-unknown	GHGSTS...	495	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153366

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VEKDSG	494	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11683
...VEKDSG	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136790
...VISQN	862	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VISQN	862	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81295

TopFIND

P54278: Mismatch repair endonuclease PMS2 {ECO:0000305}

General Information

2

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates