P54868: Hydroxymethylglutaryl-CoA synthase, mitochondrial

General Information

Protein names	- Hydroxymethylglutaryl-CoA synthase, mitochondrial - HMG-CoA synthase - 2.3.3.10 - 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene names	HMGCS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54868

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Hydroxymethylglutaryl-CoA synthase, mitochondrial - Isoform 3 of Hydroxymethylglutaryl-CoA synthase, mitochondrial

Sequence View

        10         20         30         40         50         60
MQRLLTPVKR ILQLTRAVQE TSLTPARLLP VAHQRFSTAS AVPLAKTDTW PKDVGILALE
        70         80         90        100        110        120
VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERIQLP
       130        140        150        160        170        180
WDSVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM
       190        200        210        220        230        240
ESSSWDGRYA MVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLALERGL RGTHMENVYD
       250        260        270        280        290        300
FYKPNLASEY PIVDGKLSIQ CYLRALDRCY TSYRKKIQNQ WKQAGSDRPF TLDDLQYMIF
       310        320        330        340        350        360
HTPFCKMVQK SLARLMFNDF LSASSDTQTS LYKGLEAFGG LKLEDTYTNK DLDKALLKAS
       370        380        390        400        410        420
QDMFDKKTKA SLYLSTHNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF
       430        440        450        460        470        480
FSFRVSQDAA PGSPLDKLVS STSDLPKRLA SRKCVSPEEF TEIMNQREQF YHKVNFSPPG
       490        500
DTNSLFPGTW YLERVDEQHR RKYARRPV         10         20         30         40         50         60
MQRLLTPVKR ILQLTRAVQE TSLTPARLLP VAHQRFSTAS AVPLAKTDTW PKDVGILALE
        70         80         90        100        110        120
VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERIQLP
       130        140        150        160        170        180
WDSVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM
       190        200        210        220        230        240
ESSSWDGRYA MVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLALERGL RGTHMENVYD
       250        260        270        280        290        300
FYKPNLASEY PIVDGKLSIQ CYLRALDRCY TSYRKKIQNQ WKQAGSDRPF TLDDLQYMIF
       310        320        330        340        350        360
HTPFCKMVQK SLARLMFNDF LSASSDTQTS LYKGLEAFGG LKLEDTYTNK DLDKALLKAS
       370        380        390        400        410        420
QDMFDKKTKA SLYLSTHNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF
       430        440        450        460        470        480
FSFRVSQDAA PGSPLDKLVS STSDLPKRLA SRKCVSPEEF TEIMNQREQF YHKVNFSPPG
       490        500
DTNSLFPGTW YLERVDEQHR RKYARRPV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54868-1-unknown	MQRLLT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77069
P54868-1-unknown	MQRLLT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77070
P54868-38-unknown	TASAVP...	38	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54868-38-unknown	TASAVP...	38	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115336
P54868-38-unknown	TASAVP...	38	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115337
P54868-435-unknown	LDKLVS...	435	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177082
P54868-435-unknown	LDKLVS...	435	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177083
P54868-435-	LDKLVS...	435		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARRPV	508	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ARRPV	508	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72688
...ARRPV	508	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72687

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)