P55010: Eukaryotic translation initiation factor 5

General Information

Protein names	- Eukaryotic translation initiation factor 5 - eIF-5
Gene names	EIF5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55010

3 N-termini

8 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVNVNRSVS DQFYRYKMPR LIAKVEGKGN GIKTVIVNMV DVAKALNRPP TYPTKYFGCE
        70         80         90        100        110        120
LGAQTQFDVK NDRYIVNGSH EANKLQDMLD GFIKKFVLCP ECENPETDLH VNPKKQTIGN
       130        140        150        160        170        180
SCKACGYRGM LDTHHKLCTF ILKNPPENSD SGTGKKEKEK KNRKGKDKEN GSVSSSETPP
       190        200        210        220        230        240
PPPPPNEINP PPHTMEEEED DDWGEDTTEE AQRRRMDEIS DHAKVLTLSD DLERTIEERV
       250        260        270        280        290        300
NILFDFVKKK KEEGVIDSSD KEIVAEAERL DVKAMGPLVL TEVLFNEKIR EQIKKYRRHF
       310        320        330        340        350        360
LRFCHNNKKA QRYLLHGLEC VVAMHQAQLI SKIPHILKEM YDADLLEEEV IISWSEKASK
       370        380        390        400        410        420
KYVSKELAKE IRVKAEPFIK WLKEAEEESS GGEEEDEDEN IEVVYSKAAS VPKVETVKSD
       430
NKDDDIDIDA I

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 8 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P55010-1-unknown	MSVNVN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55010-2-acetylation	SVNVNR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P55010-2-acetylation	SVNVNR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P55010-99-unknown	CPECEN...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7576

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NRPPTY	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452636
...QTQFDV	68	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452615
...KKFVLC	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7576
...VLCPEC	101	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453633
...PETDLH	109	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452883
...PETDLH	109	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453468
...LKNPPE	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453396
...EEEEDD	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453856
...DIDAI	431	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	98	FVLC.\|.CPEC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)