P63010: AP-2 complex subunit beta

General Information

Protein names	- AP-2 complex subunit beta - AP105B - Adaptor protein complex AP-2 subunit beta - Adaptor-related protein complex 2 subunit beta - Beta-2-adaptin - Beta-adaptin - Clathrin assembly protein complex 2 beta large chain - Plasma membrane adaptor HA2/AP2 adaptin beta subunit
Gene names	AP2B1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63010

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of AP-2 complex subunit beta - Isoform 3 of AP-2 complex subunit beta

Sequence View

        10         20         30         40         50         60
MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT
        70         80         90        100        110        120
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE
       130        140        150        160        170        180
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA
       190        200        210        220        230        240
VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI
       250        260        270        280        290        300
CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY
       310        320        330        340        350        360
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
       370        380        390        400        410        420
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK
       430        440        450        460        470        480
YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
       490        500        510        520        530        540
QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV
       550        560        570        580        590        600
VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST
       610        620        630        640        650        660
DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL
       670        680        690        700        710        720
DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI GMAPGGYVAP KAVWLPAVKA
       730        740        750        760        770        780
KGLEISGTFT HRQGHIYMEM NFTNKALQHM TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ
       790        800        810        820        830        840
SIDVSLPLNT LGPVMKMEPL NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT
       850        860        870        880        890        900
WKDIPNENEL QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL
       910        920        930
AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN         10         20         30         40         50         60
MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT
        70         80         90        100        110        120
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE
       130        140        150        160        170        180
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA
       190        200        210        220        230        240
VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI
       250        260        270        280        290        300
CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY
       310        320        330        340        350        360
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
       370        380        390        400        410        420
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK
       430        440        450        460        470        480
YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
       490        500        510        520        530        540
QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV
       550        560        570        580        590        600
VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST
       610        620        630        640        650        660
DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL
       670        680        690        700        710        720
DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI GMAPGGYVAP KAVWLPAVKA
       730        740        750        760        770        780
KGLEISGTFT HRQGHIYMEM NFTNKALQHM TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ
       790        800        810        820        830        840
SIDVSLPLNT LGPVMKMEPL NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT
       850        860        870        880        890        900
WKDIPNENEL QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL
       910        920        930
AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63010-1-unknown	MTDSKY...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67146
P63010-2-unknown	MTDSKY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63010-2-Acetylation	TDSKYF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63010-2-Acetylation	TDSKYF...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63010-2-Acetylation	TDSKYF...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111681
P63010-19-unknown	KAELNN...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14282
P63010-19-unknown	KAELNN...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136802
P63010-58-unknown	MQTDNL...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67147
P63010-58-unknown	MQTDNL...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100128
P63010-572-unknown	SVYHKP...	572		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177377
P63010-572-unknown	SVYHKP...	572		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177378
P63010-572-	SVYHKP...	572			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EIFELK	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14282
...SILKN	937	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SILKN	937	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62765
...SILKN	937	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62764

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	18	FELK.\|.KAEL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)