P68871: Hemoglobin subunit beta

General Information

Protein names	- Hemoglobin subunit beta - Beta-globin - Hemoglobin beta chain - LVV-hemorphin-7 - Spinorphin
Gene names	HBB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P68871

61 N-termini

10 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS TPDAVMGNPK
        70         80         90        100        110        120
VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELHCDKLHVD PENFRLLGNV LVCVLAHHFG
       130        140
KEFTPPVQAA YQKVVAGVAN ALAHKYH

Isoforms

Sequence View

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Directness:

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

61 N-termini - 10 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P68871-2-unknown	MVHLTP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68871-1-	MVHLTP...	1			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-1-acetylation	MVHLTP...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-2-Acetylation	VHLTPE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68871-2-Acetylation	VHLTPE...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-2-	VHLTPE...	2			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-3-	HLTPEE...	3			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-4-unknown	LTPEEK...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4597
P68871-4-	LTPEEK...	4			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-4-acetylation	LTPEEK...	4	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-5-unknown	TPEEKS...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4598
P68871-5-	TPEEKS...	5			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-7-Pyrrolidone carboxylic acid (Glu)	EEKSAV...	7	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-7-acetylation	EEKSAV...	7	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-8-Pyrrolidone carboxylic acid (Glu)	EKSAVT...	8	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-8-	EKSAVT...	8			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-8-acetylation	EKSAVT...	8	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-9-	KSAVTA...	9			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-9-acetylation	KSAVTA...	9	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-10-	SAVTAL...	10			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-10-acetylation	SAVTAL...	10	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-11-	AVTALW...	11			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-11-acetylation	AVTALW...	11	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-12-	VTALWG...	12			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-12-acetylation	VTALWG...	12	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-13-	TALWGK...	13			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-13-acetylation	TALWGK...	13	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-14-	ALWGKV...	14			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-14-acetylation	ALWGKV...	14	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-15-unknown	LWGKVN...	15		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4599
P68871-15-	LWGKVN...	15			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-15-acetylation	LWGKVN...	15	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-16-unknown	WGKVNV...	16		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4600
P68871-16-	WGKVNV...	16			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-16-acetylation	WGKVNV...	16	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-17-	GKVNVD...	17			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-17-acetylation	GKVNVD...	17	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-18-	KVNVDE...	18			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-19-	VNVDEV...	19			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-19-acetylation	VNVDEV...	19	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-20-	NVDEVG...	20			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-20-acetylation	NVDEVG...	20	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-32-unknown	LLVVYP...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4601
P68871-33-unknown	LVVYPW...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4602
P68871-42-unknown	FFESFG...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4603
P68871-42-	FFESFG...	42			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-42-acetylation	FFESFG...	42	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-45-	SFGDLS...	45			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-46-unknown	FGDLST...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4604
P68871-68-acetylation	VLGAFS...	68	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-71-	AFSDGL...	71			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-71-acetylation	AFSDGL...	71	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-84-	GTFATL...	84			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-84-acetylation	GTFATL...	84	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-85-	TFATLS...	85			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-86-unknown	FATLSE...	86		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4605
P68871-86-	FATLSE...	86			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-87-	ATLSEL...	87			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-87-acetylation	ATLSEL...	87	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-88-	TLSELH...	88			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-123-acetylation	FTPPVQ...	123	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P68871-130-unknown	AYQKVV...	130		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4606

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SAVTAL	14	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4599
...AVTALW	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4600
...EALGRL	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4601
...ALGRLL	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4602
...PWTQRF	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4603
...RFFESF	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4604
...NLKGTF	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4605
...FATLSE	90	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000369671
...PPVQAA	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4606
...AHKYH	147	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATD_HUMAN	3	MVHL.\|.LTPE	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	4	VHLT.\|.TPEE	inferred from experiment	unknown	MEROPS		Merops CATD_HUMAN -> HBB_HUMAN @4
CATD_HUMAN	14	VTAL.\|.LWGK	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	15	TALW.\|.WGKV	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	31	LGRL.\|.LLVV	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	32	GRLL.\|.LVVY	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	41	TQRF.\|.FFES	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	45	FESF.\|.FGDL	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	85	KGTF.\|.FATL	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,
CATD_HUMAN	129	VQAA.\|.AYQK	inferred from experiment	unknown	MEROPS	McManus DP	Brindley PJ et al.:Proteolysis of human hemoglobin... (A01.009)	11166391,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)