P70268: Serine/threonine-protein kinase N1

General Information

Protein names	- Serine/threonine-protein kinase N1 - 2.7.11.13 {ECO:0000250\|UniProtKB:Q16512} - Protein kinase C-like 1 - Protein kinase C-like PKN - Protein-kinase C-related kinase 1 - Serine-threonine protein kinase N
Gene names	Pkn1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P70268

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLKREIRKEL KLKEGAENLR
        70         80         90        100        110        120
RATTDLGRSL APVELLLRGS ARRLDLLHQQ LQELHAHVVL PDPAAGSDAT QSLAEGSPIC
       130        140        150        160        170        180
SSTNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSSKDR KLLLTAQQML QDSKTKIDII
       190        200        210        220        230        240
RMQLRRALQA LQAGELESQA APDEAQGDPE LGAVELRIEE LRHHFRVEHA VAEGAKNVLR
       250        260        270        280        290        300
LLSGAKAPDR KAVSEAQEKL TESNQKLGLL RESLERRLGE LPADHPKGRL LREELTAASS
       310        320        330        340        350        360
SAFSAILPGP FPATHYSTLS KPAPLTGTLE VRVVGCKNLP ETIPWSPPPS VGASGTPESR
       370        380        390        400        410        420
TPFLSRPARG LYSRSGSLSG RSSLRGEAEN ATEVSTVLKL DNTVVGQTAW KPCGPNAWDQ
       430        440        450        460        470        480
SFTLELERAR ELELAVFWRD QRGLCALKFL KLEDFLDNER HEVQLDMEPQ GCLVAEVTFR
       490        500        510        520        530        540
NPIIERIPRL QRQKKIFSKQ QGKAFQRARQ MNIDVATWVR LLRRLIPSAV ATGTFSPNAS
       550        560        570        580        590        600
PGAEIRHTGD ISMEKLNLGA DSDSSSQKSP PGLPSTSCSL SSPTHESTTS PELPSETQET
       610        620        630        640        650        660
PGPGLCSPLR KSPLTLEDFK FLAVLGRGHF GKVLLSEFRS SGELFAIKAL KKGDIVARDE
       670        680        690        700        710        720
VESLMCEKRI LAAVTRAGHP FLVNLFGCFQ TPEHVCFVME YSAGGDLMLH IHSDVFSEPR
       730        740        750        760        770        780
AVFYSACVVL GLQFLHEHKI VYRDLKLDNL LLDTEGYVKI ADFGLCKEGM GYGDRTSTFC
       790        800        810        820        830        840
GTPEFLAPEV LTDTSYTRAV DWWGLGVLLY EMLVGESPFP GDDEEEVFDS IVNDEVRYPR
       850        860        870        880        890        900
FLSAEAIGIM RRLLRRNPER RLGSTERDAE DVKKQPFFRS LGWDVLLARR LPPPFVPTLS
       910        920        930        940
GRTDVSNFDE EFTGEAPTLS PPRDARPLTA AEQAAFRDFD FVAGGY

Isoforms

- Isoform 2 of Serine/threonine-protein kinase N1 - Isoform 2 of Serine/threonine-protein kinase N1

Sequence View

        10         20         30         40         50         60
MAGDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLKREIRKEL KLKEGAENLR
        70         80         90        100        110        120
RATTDLGRSL APVELLLRGS ARRLDLLHQQ LQELHAHVVL PDPAAGSDAT QSLAEGSPIC
       130        140        150        160        170        180
SSTNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSSKDR KLLLTAQQML QDSKTKIDII
       190        200        210        220        230        240
RMQLRRALQA LQAGELESQA APDEAQGDPE LGAVELRIEE LRHHFRVEHA VAEGAKNVLR
       250        260        270        280        290        300
LLSGAKAPDR KAVSEAQEKL TESNQKLGLL RESLERRLGE LPADHPKGRL LREELTAASS
       310        320        330        340        350        360
SAFSAILPGP FPATHYSTLS KPAPLTGTLE VRVVGCKNLP ETIPWSPPPS VGASGTPESR
       370        380        390        400        410        420
TPFLSRPARG LYSRSGSLSG RSSLRGEAEN ATEVSTVLKL DNTVVGQTAW KPCGPNAWDQ
       430        440        450        460        470        480
SFTLELERAR ELELAVFWRD QRGLCALKFL KLEDFLDNER HEVQLDMEPQ GCLVAEVTFR
       490        500        510        520        530        540
NPIIERIPRL QRQKKIFSKQ QGKAFQRARQ MNIDVATWVR LLRRLIPSAV ATGTFSPNAS
       550        560        570        580        590        600
PGAEIRHTGD ISMEKLNLGA DSDSSSQKSP PGLPSTSCSL SSPTHESTTS PELPSETQET
       610        620        630        640        650        660
PGPGLCSPLR KSPLTLEDFK FLAVLGRGHF GKVLLSEFRS SGELFAIKAL KKGDIVARDE
       670        680        690        700        710        720
VESLMCEKRI LAAVTRAGHP FLVNLFGCFQ TPEHVCFVME YSAGGDLMLH IHSDVFSEPR
       730        740        750        760        770        780
AVFYSACVVL GLQFLHEHKI VYRDLKLDNL LLDTEGYVKI ADFGLCKEGM GYGDRTSTFC
       790        800        810        820        830        840
GTPEFLAPEV LTDTSYTRAV DWWGLGVLLY EMLVGESPFP GDDEEEVFDS IVNDEVRYPR
       850        860        870        880        890        900
FLSAEAIGIM RRLLRRNPER RLGSTERDAE DVKKQPFFRS LGWDVLLARR LPPPFVPTLS
       910        920        930        940
GRTDVSNFDE EFTGEAPTLS PPRDARPLTA AEQAAFRDFD FVAGGY         10         20         30         40         50         60
MAGDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLKREIRKEL KLKEGAENLR
        70         80         90        100        110        120
RATTDLGRSL APVELLLRGS ARRLDLLHQQ LQELHAHVVL PDPAAGSDAT QSLAEGSPIC
       130        140        150        160        170        180
SSTNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSSKDR KLLLTAQQML QDSKTKIDII
       190        200        210        220        230        240
RMQLRRALQA LQAGELESQA APDEAQGDPE LGAVELRIEE LRHHFRVEHA VAEGAKNVLR
       250        260        270        280        290        300
LLSGAKAPDR KAVSEAQEKL TESNQKLGLL RESLERRLGE LPADHPKGRL LREELTAASS
       310        320        330        340        350        360
SAFSAILPGP FPATHYSTLS KPAPLTGTLE VRVVGCKNLP ETIPWSPPPS VGASGTPESR
       370        380        390        400        410        420
TPFLSRPARG LYSRSGSLSG RSSLRGEAEN ATEVSTVLKL DNTVVGQTAW KPCGPNAWDQ
       430        440        450        460        470        480
SFTLELERAR ELELAVFWRD QRGLCALKFL KLEDFLDNER HEVQLDMEPQ GCLVAEVTFR
       490        500        510        520        530        540
NPIIERIPRL QRQKKIFSKQ QGKAFQRARQ MNIDVATWVR LLRRLIPSAV ATGTFSPNAS
       550        560        570        580        590        600
PGAEIRHTGD ISMEKLNLGA DSDSSSQKSP PGLPSTSCSL SSPTHESTTS PELPSETQET
       610        620        630        640        650        660
PGPGLCSPLR KSPLTLEDFK FLAVLGRGHF GKVLLSEFRS SGELFAIKAL KKGDIVARDE
       670        680        690        700        710        720
VESLMCEKRI LAAVTRAGHP FLVNLFGCFQ TPEHVCFVME YSAGGDLMLH IHSDVFSEPR
       730        740        750        760        770        780
AVFYSACVVL GLQFLHEHKI VYRDLKLDNL LLDTEGYVKI ADFGLCKEGM GYGDRTSTFC
       790        800        810        820        830        840
GTPEFLAPEV LTDTSYTRAV DWWGLGVLLY EMLVGESPFP GDDEEEVFDS IVNDEVRYPR
       850        860        870        880        890        900
FLSAEAIGIM RRLLRRNPER RLGSTERDAE DVKKQPFFRS LGWDVLLARR LPPPFVPTLS
       910        920        930        940
GRTDVSNFDE EFTGEAPTLS PPRDARPLTA AEQAAFRDFD FVAGGY

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P70268-2-unknown	MAGDAV...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P70268-2-unknown	MAGDAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P70268-2-Acetylation	AGDAVQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P70268-2-Acetylation	AGDAVQ...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P70268-16-unknown	LEQLGL...	16		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30324
P70268-16-unknown	LEQLGL...	16		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195070
P70268-204-unknown	EAQGDP...	204		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32391
P70268-204-unknown	EAQGDP...	204		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146956

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RSWSLL	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30324
...QAAPDE	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32391
...QAAPDE	203	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130288
...VAGGY	946	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VAGGY	946	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81059

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	15	WSLL.\|.LEQL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PKN1_MOUSE @15
GRAB_MOUSE	203	APDE.\|.EAQG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

TopFIND

P70268: Serine/threonine-protein kinase N1

General Information

4

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates