P78344: Eukaryotic translation initiation factor 4 gamma 2

General Information

Protein names	- Eukaryotic translation initiation factor 4 gamma 2 - eIF-4-gamma 2 - eIF-4G 2 - eIF4G 2 - Death-associated protein 5 - DAP-5 - p97
Gene names	EIF4G2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P78344

16 N-termini

11 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESAIAEGGA SRFSASSGGG GSRGAPQHYP KTAGNSEFLG KTPGQNAQKW IPARSTRRDD
        70         80         90        100        110        120
NSAANNSANE KERHDAIFRK VRGILNKLTP EKFDKLCLEL LNVGVESKLI LKGVILLIVD
       130        140        150        160        170        180
KALEEPKYSS LYAQLCLRLA EDAPNFDGPA AEGQPGQKQS TTFRRLLISK LQDEFENRTR
       190        200        210        220        230        240
NVDVYDKREN PLLPEEEEQR AIAKIKMLGN IKFIGELGKL DLIHESILHK CIKTLLEKKK
       250        260        270        280        290        300
RVQLKDMGED LECLCQIMRT VGPRLDHERA KSLMDQYFAR MCSLMLSKEL PARIRFLLQD
       310        320        330        340        350        360
TVELREHHWV PRKAFLDNGP KTINQIRQDA VKDLGVFIPA PMAQGMRSDF FLEGPFMPPR
       370        380        390        400        410        420
MKMDRDPLGG LADMFGQMPG SGIGTGPGVI QDRFSPTMGR HRSNQLFNGH GGHIMPPTQS
       430        440        450        460        470        480
QFGEMGGKFM KSQGLSQLYH NQSQGLLSQL QGQSKDMPPR FSKKGQLNAD EISLRPAQSF
       490        500        510        520        530        540
LMNKNQVPKL QPQITMIPPS AQPPRTQTPP LGQTPQLGLK TNPPLIQEKP AKTSKKPPPS
       550        560        570        580        590        600
KEELLKLTET VVTEYLNSGN ANEAVNGVRE MRAPKHFLPE MLSKVIILSL DRSDEDKEKA
       610        620        630        640        650        660
SSLISLLKQE GIATSDNFMQ AFLNVLDQCP KLEVDIPLVK SYLAQFAARA IISELVSISE
       670        680        690        700        710        720
LAQPLESGTH FPLFLLCLQQ LAKLQDREWL TELFQQSKVN MQKMLPEIDQ NKDRMLEILE
       730        740        750        760        770        780
GKGLSFLFPL LKLEKELLKQ IKLDPSPQTI YKWIKDNISP KLHVDKGFVN ILMTSFLQYI
       790        800        810        820        830        840
SSEVNPPSDE TDSSSAPSKE QLEQEKQLLL SFKPVMQKFL HDHVDLQVSA LYALQVHCYN
       850        860        870        880        890        900
SNFPKGMLLR FFVHFYDMEI IEEEAFLAWK EDITQEFPGK GKALFQVNQW LTWLETAEEE

ESEEEAD

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 4 gamma 2

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 11 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P78344-1-Acetylation	MESAIA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78344-1-Acetylation	MESAIA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P78344-1-Acetylation	MESAIA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P78344-1-Acetylation	MESAIA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P78344-1-Acetylation	MESAIA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107694
P78344-1-unknown	MESAIA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77558
P78344-24-	GAPQHY...	24			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P78344-24-unknown	GAPQHY...	24		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170000
P78344-29-unknown	YPKTAG...	29		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P78344-29-unknown	YPKTAG...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195568
P78344-59-unknown	DDNSAA...	59		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P78344-59-unknown	DDNSAA...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196297
P78344-336-unknown	VFIPAP...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166876
P78344-336-	VFIPAP...	336			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P78344-352-unknown	LEGPFM...	352			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P78344-352-unknown	LEGPFM...	352		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159799
P78344-496-unknown	MIPPSA...	496		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433561
P78344-496-unknown	MIPPSA...	496		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130427
P78344-496-	MIPPSA...	496			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P78344-501-unknown	AQPPRT...	501		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166874
P78344-501-	AQPPRT...	501			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P78344-604-unknown	ISLLKQ...	604		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434815
P78344-604-unknown	ISLLKQ...	604		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130425
P78344-793-unknown	SSSAPS...	793		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1982
P78344-793-unknown	SSSAPS...	793		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156288
P78344-793-	SSSAPS...	793			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P78344-793-	SSSAPS...	793			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P78344-793-	SSSAPS...	793			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P78344-793-	SSSAPS...	793			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NVGVES	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435912
...NVGVES	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109747
...KLILKG	112	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436235
...KLILKG	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109745
...KGVILL	116	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433335
...KGVILL	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109743
...EPKYSS	129	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431511
...EPKYSS	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109741
...GQPGQK	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434940
...GQPGQK	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109739
...KRVQLK	244	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435523
...KRVQLK	244	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109737
...FARMCS	282	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433121
...FARMCS	282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109735
...MQKMLP	705	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433561
...MQKMLP	705	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109732
...SDETDS	792	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1982
...SDETDS	792	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139760
...KALFQV	886	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434815
...KALFQV	886	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt109730
...EEEAD	907	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EEEAD	907	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73176

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	792	ETDS.\|.SSSA	inferred from experiment	unknown	MEROPS	Kimchi A	Henis-Korenblit S et al.:A novel form of DAP5 protein ac... (C14.003)	10611228,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)