P80303: Nucleobindin-2 {ECO:0000305}
Protein names | - Nucleobindin-2 {ECO:0000305} - DNA-binding protein NEFA - Epididymis secretory protein Li 109 {ECO:0000303|Ref.6} - Gastric cancer antigen Zg4 - Prepronesfatin - Nesfatin-1 |
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Gene names | NUCB2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P80303 |
6
N-termini
4
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MRWRTILLQY CFLLITCLLT ALEAVPIDID KTKVQNIHPV ESAKIEPPDT GLYYDEYLKQ
70 80 90 100 110 120
VIDVLETDKH FREKLQKADI EEIKSGRLSK ELDLVSHHVR TKLDELKRQE VGRLRMLIKA
130 140 150 160 170 180
KLDSLQDIGM DHQALLKQFD HLNHLNPDKF ESTDLDMLIK AATSDLEHYD KTRHEEFKKY
190 200 210 220 230 240
EMMKEHERRE YLKTLNEEKR KEEESKFEEM KKKHENHPKV NHPGSKDQLK EVWEETDGLD
250 260 270 280 290 300
PNDFDPKTFF KLHDVNSDGF LDEQELEALF TKELEKVYDP KNEEDDMVEM EEERLRMREH
310 320 330 340 350 360
VMNEVDTNKD RLVTLEEFLK ATEKKEFLEP DSWETLDQQQ FFTEEELKEY ENIIALQENE
370 380 390 400 410 420
LKKKADELQK QKEELQRQHD QLEAQKLEYH QVIQQMEQKK LQQGIPPSGP AGELKFEPHI
Isoforms
- Isoform 2 of Nucleobindin-2 - Isoform 2 of Nucleobindin-2Sequence View
10 20 30 40 50 60
MRWRTILLQY CFLLITCLLT ALEAVPIDID KTKVQNIHPV ESAKIEPPDT GLYYDEYLKQ
70 80 90 100 110 120
VIDVLETDKH FREKLQKADI EEIKSGRLSK ELDLVSHHVR TKLDELKRQE VGRLRMLIKA
130 140 150 160 170 180
KLDSLQDIGM DHQALLKQFD HLNHLNPDKF ESTDLDMLIK AATSDLEHYD KTRHEEFKKY
190 200 210 220 230 240
EMMKEHERRE YLKTLNEEKR KEEESKFEEM KKKHENHPKV NHPGSKDQLK EVWEETDGLD
250 260 270 280 290 300
PNDFDPKTFF KLHDVNSDGF LDEQELEALF TKELEKVYDP KNEEDDMVEM EEERLRMREH
310 320 330 340 350 360
VMNEVDTNKD RLVTLEEFLK ATEKKEFLEP DSWETLDQQQ FFTEEELKEY ENIIALQENE
370 380 390 400 410 420
LKKKADELQK QKEELQRQHD QLEAQKLEYH QVIQQMEQKK LQQGIPPSGP AGELKFEPHI
10 20 30 40 50 60
MRWRTILLQY CFLLITCLLT ALEAVPIDID KTKVQNIHPV ESAKIEPPDT GLYYDEYLKQ
70 80 90 100 110 120
VIDVLETDKH FREKLQKADI EEIKSGRLSK ELDLVSHHVR TKLDELKRQE VGRLRMLIKA
130 140 150 160 170 180
KLDSLQDIGM DHQALLKQFD HLNHLNPDKF ESTDLDMLIK AATSDLEHYD KTRHEEFKKY
190 200 210 220 230 240
EMMKEHERRE YLKTLNEEKR KEEESKFEEM KKKHENHPKV NHPGSKDQLK EVWEETDGLD
250 260 270 280 290 300
PNDFDPKTFF KLHDVNSDGF LDEQELEALF TKELEKVYDP KNEEDDMVEM EEERLRMREH
310 320 330 340 350 360
VMNEVDTNKD RLVTLEEFLK ATEKKEFLEP DSWETLDQQQ FFTEEELKEY ENIIALQENE
370 380 390 400 410 420
LKKKADELQK QKEELQRQHD QLEAQKLEYH QVIQQMEQKK LQQGIPPSGP AGELKFEPHI
Protein Neighborhood
Domains & Features
6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P80303-1-unknown | MRWRTI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt83492 | |||
P80303-25-unknown | VPIDID... | 25 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P80303-25-unknown | VPIDID... | 25 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113847 | |||
P80303-238-unknown | GLDPND... | 238 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1261 | |||
P80303-238-unknown | GLDPND... | 238 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P80303-238-unknown | GLDPND... | 238 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148003 | |||
P80303-238- | GLDPND... | 238 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P80303-259-unknown | GFLDEQ... | 259 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1263 | |||
P80303-259-unknown | GFLDEQ... | 259 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148788 | |||
P80303-259- | GFLDEQ... | 259 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P80303-259- | GFLDEQ... | 259 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KLDELK | 106 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...KLDELK | 106 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91517 | |||
...WEETDG | 237 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1261 | |||
...WEETDG | 237 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131366 | |||
...DVNSDG | 258 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1263 | |||
...DVNSDG | 258 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132164 | |||
...FEPHI | 420 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASP1_HUMAN | 237 | ETDG.|.GLDP | inferred from experiment | unknown | MEROPS | Wells JA | Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001) | 20173201, |
CASP1_HUMAN | 258 | NSDG.|.GFLD | inferred from experiment | unknown | MEROPS | Wells JA | Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001) | 20173201, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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