P81605: Dermcidin

General Information

Protein names	- Dermcidin - 3.4.-.- - Preproteolysin - Survival-promoting peptide - DCD-1
Gene names	DCD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P81605

3 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG LARQAPKPRK
70 80 90 100 110
QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH DVKDVLDSVL

Isoforms

- Isoform 2 of Dermcidin - Isoform 3 of Dermcidin

Sequence View

        10         20         30         40         50         60
MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG LARQAPKPRK
        70         80         90        100        110
QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH DVKDVLDSVL         10         20         30         40         50         60
MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG LARQAPKPRK
        70         80         90        100        110
QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH DVKDVLDSVL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P81605-1-unknown	MRFMTL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt72438
P81605-1-unknown	MRFMTL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt72439
P81605-20-unknown	YDPEAA...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P81605-20-unknown	YDPEAA...	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14321
P81605-20-unknown	YDPEAA...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112340
P81605-92-unknown	ESVGKG...	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4625

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALVCAY	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14321
...AVEDLE	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4625
...AVEDLE	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154282
...VKDVLD	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4626
...LDSVL	110	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	19	VCAY.\|.YDPE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATD_HUMAN	91	EDLE.\|.ESVG	inferred from experiment	unknown	MEROPS	Kalbacher H	Baechle D et al.:Cathepsin D is present in human... (A01.009)	16354654,
CATD_HUMAN	106	DVLD.\|.DSVL	inferred from experiment	unknown	MEROPS	Kalbacher H	Baechle D et al.:Cathepsin D is present in human... (A01.009)	16354654,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)