Q00537: Cyclin-dependent kinase 17

General Information

Protein names	- Cyclin-dependent kinase 17 - 2.7.11.22 - Cell division protein kinase 17 - PCTAIRE-motif protein kinase 2 - Serine/threonine-protein kinase PCTAIRE-2
Gene names	CDK17
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q00537

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEENSSKDNE PIVKNGRPPT SHSMHSFLHQ
        70         80         90        100        110        120
YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN LKMGSDGESD QASGTSSDEV
       130        140        150        160        170        180
QSPTGVCLRN RIHRRISMED LNKRLSLPAD IRIPDGYLEK LQINSPPFDQ PMSRRSRRAS
       190        200        210        220        230        240
LSEIGFGKME TYIKLEKLGE GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS
       250        260        270        280        290        300
LLKDLKHANI VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG
       310        320        330        340        350        360
LAYCHRRKVL HRDLKPQNLL INEKGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL
       370        380        390        400        410        420
LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL IFRLLGTPSQ ETWPGISSNE
       430        440        450        460        470        480
EFKNYNFPKY KPQPLINHAP RLDSEGIELI TKFLQYESKK RVSAEEAMKH VYFRSLGPRI
       490        500        510        520
HALPESVSIF SLKEIQLQKD PGFRNSSYPE TGHGKNRRQS MLF

Isoforms

- Isoform 2 of Cyclin-dependent kinase 17

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00537-1-acetylation	MKKFKR...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q00537-1-acetylation	MKKFKR...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q00537-1-acetylation	MKKFKR...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162973
Q00537-1-unknown	MKKFKR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00537-1-unknown	MKKFKR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70097
Q00537-219-unknown	ALKEIR...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10175
Q00537-219-unknown	ALKEIR...	219		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147329

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TENLVA	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10175
...TENLVA	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130672
...QSMLF	523	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	218	NLVA.\|.ALKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)