Q02078: Myocyte-specific enhancer factor 2A

General Information

Protein names	- Myocyte-specific enhancer factor 2A - Serum response factor-like protein 1
Gene names	MEF2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02078

4 N-termini

4 C-termini

8 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform MEFA of Myocyte-specific enhancer factor 2A - Isoform RSRFC4 of Myocyte-specific enhancer factor 2A - Isoform RSRFC9 of Myocyte-specific enhancer factor 2A - Isoform 5 of Myocyte-specific enhancer factor 2A - Isoform 6 of Myocyte-specific enhancer factor 2A - Isoform 7 of Myocyte-specific enhancer factor 2A - Isoform 8 of Myocyte-specific enhancer factor 2A

Sequence View

        10         20         30         40         50         60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE
       130        140        150        160        170        180
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML
       190        200        210        220        230        240
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG
       250        260        270        280        290        300
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
       310        320        330        340        350        360
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS
       370        380        390        400        410        420
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ
       430        440        450        460        470        480
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP
       490        500
IVLGRPPNTE DRESPSVKRM RMDAWVT         10         20         30         40         50         60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE
       130        140        150        160        170        180
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML
       190        200        210        220        230        240
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG
       250        260        270        280        290        300
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
       310        320        330        340        350        360
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS
       370        380        390        400        410        420
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ
       430        440        450        460        470        480
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP
       490        500
IVLGRPPNTE DRESPSVKRM RMDAWVT         10         20         30         40         50         60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE
       130        140        150        160        170        180
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML
       190        200        210        220        230        240
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG
       250        260        270        280        290        300
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
       310        320        330        340        350        360
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS
       370        380        390        400        410        420
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ
       430        440        450        460        470        480
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP
       490        500
IVLGRPPNTE DRESPSVKRM RMDAWVT         10         20         30         40         50         60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE
       130        140        150        160        170        180
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML
       190        200        210        220        230        240
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG
       250        260        270        280        290        300
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
       310        320        330        340        350        360
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS
       370        380        390        400        410        420
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ
       430        440        450        460        470        480
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP
       490        500
IVLGRPPNTE DRESPSVKRM RMDAWVT         10         20         30         40         50         60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE
       130        140        150        160        170        180
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML
       190        200        210        220        230        240
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG
       250        260        270        280        290        300
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
       310        320        330        340        350        360
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS
       370        380        390        400        410        420
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ
       430        440        450        460        470        480
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP
       490        500
IVLGRPPNTE DRESPSVKRM RMDAWVT         10         20         30         40         50         60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE
       130        140        150        160        170        180
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML
       190        200        210        220        230        240
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG
       250        260        270        280        290        300
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
       310        320        330        340        350        360
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS
       370        380        390        400        410        420
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ
       430        440        450        460        470        480
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP
       490        500
IVLGRPPNTE DRESPSVKRM RMDAWVT         10         20         30         40         50         60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE
       130        140        150        160        170        180
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML
       190        200        210        220        230        240
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG
       250        260        270        280        290        300
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
       310        320        330        340        350        360
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS
       370        380        390        400        410        420
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ
       430        440        450        460        470        480
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP
       490        500
IVLGRPPNTE DRESPSVKRM RMDAWVT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q02078-1-unknown	MGRKKI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q02078-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80806
Q02078-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80807
Q02078-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80808
Q02078-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80809
Q02078-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80810
Q02078-177-unknown	SSMLSP...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3103
Q02078-177-unknown	SSMLSP...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2902
Q02078-177-unknown	SSMLSP...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2681
Q02078-177-unknown	SSMLSP...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2012
Q02078-177-unknown	SSMLSP...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142732
Q02078-177-unknown	SSMLSP...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142733
Q02078-177-unknown	SSMLSP...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145694
Q02078-177-unknown	SSMLSP...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145695
Q02078-177-unknown	SSMLSP...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145696
Q02078-177-unknown	SSMLSP...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145779
Q02078-177-unknown	SSMLSP...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145780
Q02078-214-unknown	LTVPNG...	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2910
Q02078-214-unknown	LTVPNG...	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2020
Q02078-214-unknown	LTVPNG...	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144487
Q02078-214-unknown	LTVPNG...	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144488
Q02078-214-unknown	LTVPNG...	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147049
Q02078-214-unknown	LTVPNG...	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147050
Q02078-214-unknown	LTVPNG...	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147051
Q02078-214-unknown	LTVPNG...	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147135
Q02078-214-unknown	LTVPNG...	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147137
Q02078-467-unknown	GSDRED...	467	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2918
Q02078-467-unknown	GSDRED...	467	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2028
Q02078-467-unknown	GSDRED...	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151820
Q02078-467-unknown	GSDRED...	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151953
Q02078-467-unknown	GSDRED...	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152839
Q02078-467-unknown	GSDRED...	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152869
Q02078-467-unknown	GSDRED...	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152870
Q02078-467-unknown	GSDRED...	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152898
Q02078-467-unknown	GSDRED...	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152976

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...STLTDS	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3103
...STLTDS	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2902
...STLTDS	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2681
...STLTDS	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2012
...STLTDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125934
...STLTDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125935
...STLTDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128992
...STLTDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128993
...STLTDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128994
...STLTDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129076
...STLTDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129077
...LSTTDL	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2910
...LSTTDL	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2020
...LSTTDL	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127752
...LSTTDL	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127753
...LSTTDL	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130382
...LSTTDL	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130383
...LSTTDL	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130384
...LSTTDL	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130470
...LSTTDL	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130472
...SSSYDG	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2918
...SSSYDG	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2028
...SSSYDG	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135224
...SSSYDG	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135361
...SSSYDG	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136264
...SSSYDG	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136294
...SSSYDG	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136295
...SSSYDG	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136323
...SSSYDG	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136402
...DAWVT	507	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DAWVT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76430
...DAWVT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76429
...DAWVT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76426
...DAWVT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76425
...DAWVT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76428
...DAWVT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76427
...DAWVT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76424

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	176	LTDS.\|.SSML	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP7_HUMAN	176	LTDS.\|.SSML	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP6_HUMAN	176	LTDS.\|.SSML	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP3_HUMAN	176	LTDS.\|.SSML	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP7_HUMAN	213	TTDL.\|.LTVP	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP3_HUMAN	213	TTDL.\|.LTVP	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP7_HUMAN	466	SYDG.\|.GSDR	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP3_HUMAN	466	SYDG.\|.GSDR	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)