Q02252: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

General Information

Protein names	- Methylmalonate-semialdehyde dehydrogenase acylating], mitochondrial - MMSDH - Malonate-semialdehyde dehydrogenase acylating] - 1.2.1.18 - 1.2.1.27 - Aldehyde dehydrogenase family 6 member A1
Gene names	ALDH6A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02252

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAALLAAAAV RARILQVSSK VKSSPTWYSA SSFSSSVPTV KLFIGGKFVE SKSDKWIDIH
        70         80         90        100        110        120
NPATNEVIGR VPQATKAEMD AAIASCKRAF PAWADTSVLS RQQVLLRYQQ LIKENLKEIA
       130        140        150        160        170        180
KLITLEQGKT LADAEGDVFR GLQVVEHACS VTSLMMGETM PSITKDMDLY SYRLPLGVCA
       190        200        210        220        230        240
GIAPFNFPAM IPLWMFPMAM VCGNTFLMKP SERVPGATML LAKLLQDSGA PDGTLNIIHG
       250        260        270        280        290        300
QHEAVNFICD HPDIKAISFV GSNKAGEYIF ERGSRHGKRV QANMGAKNHG VVMPDANKEN
       310        320        330        340        350        360
TLNQLVGAAF GAAGQRCMAL STAVLVGEAK KWLPELVEHA KNLRVNAGDQ PGADLGPLIT
       370        380        390        400        410        420
PQAKERVCNL IDSGTKEGAS ILLDGRKIKV KGYENGNFVG PTIISNVKPN MTCYKEEIFG
       430        440        450        460        470        480
PVLVVLETET LDEAIQIVNN NPYGNGTAIF TTNGATARKY AHLVDVGQVG VNVPIPVPLP
       490        500        510        520        530
MFSFTGSRSS FRGDTNFYGK QGIQFYTQLK TITSQWKEED ATLSSPAVVM PTMGR

Isoforms

- Isoform 2 of Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Sequence View

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Evidence Codes:

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Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q02252-33-	FSSSVP...	33		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q02252-33-	FSSSVP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q02252-33-	FSSSVP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02252-33-unknown	FSSSVP...	33		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02252-34-	SSSVPT...	34		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q02252-34-	SSSVPT...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q02252-34-unknown	SSSVPT...	34	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q02252-34-unknown	SSSVPT...	34	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q02252-284-unknown	MGAKNH...	284	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452081

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PTMGR	535	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)