Q02338: D-beta-hydroxybutyrate dehydrogenase, mitochondrial {ECO:0000305}

General Information

Protein names	- D-beta-hydroxybutyrate dehydrogenase, mitochondrial {ECO:0000305} - 1.1.1.30 {ECO:0000250\|UniProtKB:P29147} - 3-hydroxybutyrate dehydrogenase {ECO:0000303\|PubMed:1639787} - BDH {ECO:0000303\|PubMed:1639787} - Short chain dehydrogenase/reductase family 9C member 1
Gene names	BDH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02338

4 N-termini

7 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLATRLSRPL SRLPGKTLSA CDRENGARRP LLLGSTSFIP IGRRTYASAA EPVGSKAVLV
        70         80         90        100        110        120
TGCDSGFGFS LAKHLHSKGF LVFAGCLMKD KGHDGVKELD SLNSDRLRTV QLNVCSSEEV
       130        140        150        160        170        180
EKVVEIVRSS LKDPEKGMWG LVNNAGISTF GEVEFTSLET YKQVAEVNLW GTVRMTKSFL
       190        200        210        220        230        240
PLIRRAKGRV VNISSMLGRM ANPARSPYCI TKFGVEAFSD CLRYEMYPLG VKVSVVEPGN
       250        260        270        280        290        300
FIAATSLYSP ESIQAIAKKM WEELPEVVRK DYGKKYFDEK IAKMETYCSS GSTDTSPVID
       310        320        330        340
AVTHALTATT PYTRYHPMDY YWWLRMQIMT HLPGAISDMI YIR

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 7 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q02338-47-unknown	ASAAEP...	47	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q02338-47-unknown	ASAAEP...	47		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02338-47-unknown	ASAAEP...	47	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q02338-47-	ASAAEP...	47		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q02338-48-	SAAEPV...	48		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q02338-88-unknown	MKDKGH...	88	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411014
Q02338-88-unknown	MKDKGH...	88	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000387648

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YASAAE	50	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405462
...GCLMKD	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396149
...LIRRAK	186	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409849
...IRRAKG	187	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408685
...VKVSVV	235	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408016
...SPESIQ	253	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387648
...MIYIR	343	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)