Q02413: Desmoglein-1

General Information

Protein names	- Desmoglein-1 - Cadherin family member 4 - Desmosomal glycoprotein 1 - DG1 - DGI - Pemphigus foliaceus antigen
Gene names	DSG1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02413

9 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDWSFFRVVA MLFIFLVVVE VNSEFRIQVR DYNTKNGTIK WHSIRRQKRE WIKFAAACRE
        70         80         90        100        110        120
GEDNSKRNPI AKIHSDCAAN QQVTYRISGV GIDQPPYGIF VINQKTGEIN ITSIVDREVT
       130        140        150        160        170        180
PFFIIYCRAL NSMGQDLERP LELRVRVLDI NDNPPVFSMA TFAGQIEENS NANTLVMILN
       190        200        210        220        230        240
ATDADEPNNL NSKIAFKIIR QEPSDSPMFI INRNTGEIRT MNNFLDREQY GQYALAVRGS
       250        260        270        280        290        300
DRDGGADGMS AECECNIKIL DVNDNIPYME QSSYTIEIQE NTLNSNLLEI RVIDLDEEFS
       310        320        330        340        350        360
ANWMAVIFFI SGNEGNWFEI EMNERTNVGI LKVVKPLDYE AMQSLQLSIG VRNKAEFHHS
       370        380        390        400        410        420
IMSQYKLKAS AISVTVLNVI EGPVFRPGSK TYVVTGNMGS NDKVGDFVAT DLDTGRPSTT
       430        440        450        460        470        480
VRYVMGNNPA DLLAVDSRTG KLTLKNKVTK EQYNMLGGKY QGTILSIDDN LQRTCTGTIN
       490        500        510        520        530        540
INIQSFGNDD RTNTEPNTKI TTNTGRQEST SSTNYDTSTT STDSSQVYSS EPGNGAKDLL
       550        560        570        580        590        600
SDNVHFGPAG IGLLIMGFLV LGLVPFLMIC CDCGGAPRSA AGFEPVPECS DGAIHSWAVE
       610        620        630        640        650        660
GPQPEPRDIT TVIPQIPPDN ANIIECIDNS GVYTNEYGGR EMQDLGGGER MTGFELTEGV
       670        680        690        700        710        720
KTSGMPEICQ EYSGTLRRNS MRECREGGLN MNFMESYFCQ KAYAYADEDE GRPSNDCLLI
       730        740        750        760        770        780
YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT LGPKFKKLAD ISLGKESYPD LDPSWPPQST
       790        800        810        820        830        840
EPVCLPQETE PVVSGHPPIS PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES
       850        860        870        880        890        900
YTTSDTLKPS VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA
       910        920        930        940        950        960
PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI VTERVVSGAG
       970        980        990       1000       1010       1020
VTGISGTTGI SGGIGSSGLV GTSMGAGSGA LSGAGISGGG IGLSSLGGTA SIGHMRSSSD
      1030       1040
HHFNQTIGSA SPSTARSRIT KYSTVQYSK

Isoforms

- Isoform 2 of Desmoglein-1

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q02413-24-unknown	EFRIQV...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q02413-50-unknown	EWIKFA...	50	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q02413-50-unknown	EWIKFA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9784
Q02413-50-unknown	EWIKFA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16367
Q02413-147-unknown	VLDIND...	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16472
Q02413-243-unknown	DGGADG...	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16473
Q02413-369-unknown	ASAISV...	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16626
Q02413-423-unknown	YVMGNN...	423	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16474
Q02413-423-unknown	YVMGNN...	423	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16627
Q02413-529-unknown	SSEPGN...	529	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15998
Q02413-642-unknown	MQDLGG...	642	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462666
Q02413-889-unknown	GSNVIV...	889	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2038

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRQKRE	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9784
...RRQKRE	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16367
...ELRVRV	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16472
...RGSDRD	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16473
...QYKLKA	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16626
...STTVRY	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16474
...STTVRY	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16627
...SSQVYS	528	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15998
...PDLRDG	888	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2038
...VQYSK	1049	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	49	QKRE.\|.EWIK	inferred from experiment	unknown	MEROPS	Muller E	Posthaus H et al.:Novel insights into cadherin pr... (S08.071)	12586364,
KLK4_HUMAN	49	QKRE.\|.EWIK	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
KLK5_HUMAN	146	RVRV.\|.VLDI	inferred from experiment	unknown	MEROPS		Merops KLK5_HUMAN -> DSG1_HUMAN @146
KLK5_HUMAN	242	SDRD.\|.DGGA	inferred from experiment	unknown	MEROPS		Merops KLK5_HUMAN -> DSG1_HUMAN @242
KLK6_HUMAN	368	KLKA.\|.ASAI	inferred from experiment	unknown	MEROPS		Merops KLK6_HUMAN -> DSG1_HUMAN @368
KLK5_HUMAN	422	TVRY.\|.YVMG	inferred from experiment	unknown	MEROPS		Merops KLK5_HUMAN -> DSG1_HUMAN @422
KLK6_HUMAN	422	TVRY.\|.YVMG	inferred from experiment	unknown	MEROPS		Merops KLK6_HUMAN -> DSG1_HUMAN @422
KLK14_HUMAN	528	QVYS.\|.SSEP	inferred from experiment	unknown	MEROPS		Merops KLK14_HUMAN -> DSG1_HUMAN @528
CASP3_HUMAN	888	LRDG.\|.GSNV	inferred from experiment	unknown	MEROPS	Green KJ	Dusek RL et al.:The differentiation-dependent d... (C14.003)	16286477,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)