Q05655: Protein kinase C delta type

General Information

Protein names	- Protein kinase C delta type - 2.7.11.13 {ECO:0000269\|PubMed:18285462} - Tyrosine-protein kinase PRKCD - 2.7.10.2 - nPKC-delta - Protein kinase C delta type regulatory subunit - Protein kinase C delta type catalytic subunit - Sphingosine-dependent protein kinase-1 - SDK1
Gene names	PRKCD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q05655

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPFLRIAFN SYELGSLQAE DEANQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD
        70         80         90        100        110        120
AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY
       130        140        150        160        170        180
FLEDVDCKQS MRSEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW
       190        200        210        220        230        240
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVHNYMS
       250        260        270        280        290        300
PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQRASR
       310        320        330        340        350        360
RSDSASSEPV GIYQGFEKKT GVAGEDMQDN SGTYGKIWEG SSKCNINNFI FHKVLGKGSF
       370        380        390        400        410        420
GKVLLGELKG RGEYFAIKAL KKDVVLIDDD VECTMVEKRV LTLAAENPFL THLICTFQTK
       430        440        450        460        470        480
DHLFFVMEFL NGGDLMYHIQ DKGRFELYRA TFYAAEIMCG LQFLHSKGII YRDLKLDNVL
       490        500        510        520        530        540
LDRDGHIKIA DFGMCKENIF GESRASTFCG TPDYIAPEIL QGLKYTFSVD WWSFGVLLYE
       550        560        570        580        590        600
MLIGQSPFHG DDEDELFESI RVDTPHYPRW ITKESKDILE KLFEREPTKR LGVTGNIKIH
       610        620        630        640        650        660
PFFKTINWTL LEKRRLEPPF RPKVKSPRDY SNFDQEFLNE KARLSYSDKN LIDSMDQSAF
       670
AGFSFVNPKF EHLLED

Isoforms

- Isoform 2 of Protein kinase C delta type

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q05655-1-unknown	MAPFLR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q05655-1-unknown	MAPFLR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79210
Q05655-330-unknown	NSGTYG...	330	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q05655-330-unknown	NSGTYG...	330	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2072
Q05655-330-unknown	NSGTYG...	330	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116160
Q05655-330-unknown	NSGTYG...	330	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q05655-389-unknown	DDVECT...	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11925
Q05655-389-unknown	DDVECT...	389	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152339

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDMQDN	329	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDMQDN	329	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2072
...VVLIDD	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11925
...VVLIDD	388	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135750
...HLLED	676	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLLED	676	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74828

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	329	MQDN.\|.NSGT	inferred from experiment	unknown	MEROPS	Kufe D	Ghayur T et al.:Proteolytic activation of prote... (C14.003)	8976194,
GRAB_HUMAN	388	LIDD.\|.DDVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)