TopFIND 4.0

Q05910: Disintegrin and metalloproteinase domain-containing protein 8

General Information

Protein names
- Disintegrin and metalloproteinase domain-containing protein 8
- ADAM 8
- 3.4.24.-
- Cell surface antigen MS2
- Macrophage cysteine-rich glycoprotein
- CD156a
Gene names Adam8
Organism Mus musculus
Protease Family M12.208
Protease ID M12.208
Chromosome location
UniProt ID Q05910

2

N-termini

3

C-termini

1

Cleavages

16

Substrates

Sequence

        10         20         30         40         50         60 
MLGLWLLSVL WTPAVAPGPP LPHVKQYEVV WPRRLAASRS RRALPSHWGQ YPESLSYALG 
        70         80         90        100        110        120 
TSGHVFTLHL RKNRDLLGSS YTETYSAANG SEVTEQLQEQ DHCLYQGHVE GYEGSAASIS 
       130        140        150        160        170        180 
TCAGLRGFFR VGSTVHLIEP LDADEEGQHA MYQAKHLQQK AGTCGVKDTN LNDLGPRALE 
       190        200        210        220        230        240 
IYRAQPRNWL IPRETRYVEL YVVADSQEFQ KLGSREAVRQ RVLEVVNHVD KLYQELSFRV 
       250        260        270        280        290        300 
VLVGLEIWNK DKFYISRYAN VTLENFLSWR EQNLQGQHPH DNVQLITGVD FIGSTVGLAK 
       310        320        330        340        350        360 
VSALCSRHSG AVNQDHSKNS IGVASTMAHE LGHNLGMSHD EDIPGCYCPE PREGGGCIMT 
       370        380        390        400        410        420 
ESIGSKFPRI FSRCSKIDLE SFVTKPQTGC LTNVPDVNRF VGGPVCGNLF VEHGEQCDCG 
       430        440        450        460        470        480 
TPQDCQNPCC NATTCQLVKG AECASGTCCH ECKVKPAGEV CRLSKDKCDL EEFCDGRKPT 
       490        500        510        520        530        540 
CPEDAFQQNG TPCPGGYCFD GSCPTLAQQC RDLWGPGARV AADSCYTFSI PPGCNGRMYS 
       550        560        570        580        590        600 
GRINRCGALY CEGGQKPLER SFCTFSSNHG VCHALGTGSN IDTFELVLQG TKCEEGKVCM 
       610        620        630        640        650        660 
DGSCQDLRVY RSENCSAKCN NHGVCNHKRE CHCHKGWAPP NCVQRLADVS DEQAASTSLP 
       670        680        690        700        710        720 
VSVVVVLVIL VAAMVIVAGI VIYRKAPRQI QRRSVAPKPI SGLSNPLFYT RDSSLPAKNR 
       730        740        750        760        770        780 
PPDPSETVST NQPPRPIVKP KRPPPAPPGA VSSSPLPVPV YAPKIPNQFR PDPPTKPLPE 
       790        800        810        820    
LKPKQVKPTF APPTPPVKPG TGGTVPGATQ GAGEPKVALK VPIQKR

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 16 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q05910-17-unknown PGPPLP... 17 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q05910-402-unknown GGPVCG... 402 inferred from cleavage unknown TopFIND Inferred from cleavage TC27881

C-termini

Cleavages

Substrates