Q06186: Proheparin-binding EGF-like growth factor

General Information

Protein names	- Proheparin-binding EGF-like growth factor - Heparin-binding EGF-like growth factor - HB-EGF - HBEGF
Gene names	Hbegf
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q06186

7 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKLLPSVMLK LFLAAVLSAL VTGESLERLR RGLAAATSNP DPPTGSTNQL LPTGGDRAQG
        70         80         90        100        110        120
VQDLEGTDLN LFKVAFSSKP QGLATPSKER NGKKKKKGKG LGKKRDPCLR KYKDYCIHGE
       130        140        150        160        170        180
CRYLQEFRTP SCKCLPGYHG HRCHGLTLPV ENPLYTYDHT TVLAVVAVVL SSVCLLVIVG
       190        200
LLMFRYHRRG GYDLESEEKV KLGVASSH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q06186-24-unknown	ESLERL...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q06186-34-unknown	AAATSN...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27851
Q06186-63-unknown	DLEGTD...	63	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q06186-63-unknown	DLEGTD...	63	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q06186-90-unknown	RNGKKK...	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27839
Q06186-100-unknown	GLGKKR...	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27840
Q06186-150-unknown	VENPLY...	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27852
Q06186-156-unknown	TYDHTT...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27841

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRRGLA	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27851
...TPSKER	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27839
...KKKGKG	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27840
...HGLTLP	148	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLTLPV	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27852
...ENPLYT	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27841
...VASSH	208	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ADA17_MOUSE	33	RGLA.\|.AAAT	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
ADA10_MOUSE	89	SKER.\|.RNGK	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
ADA10_MOUSE	99	KGKG.\|.GLGK	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
ADA17_MOUSE	149	TLPV.\|.VENP	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
ADA10_MOUSE	155	PLYT.\|.TYDH	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)