Q06210: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

General Information

Protein names	- Glutamine--fructose-6-phosphate aminotransferase isomerizing] 1 - 2.6.1.16 {ECO:0000250\|UniProtKB:P82808} - D-fructose-6-phosphate amidotransferase 1 - Glutamine:fructose-6-phosphate amidotransferase 1 - GFAT 1 - GFAT1 - Hexosephosphate aminotransferase 1
Gene names	GFPT1
Organism	Homo sapiens
Protease Family
Protease ID	C44.970
Chromosome location
UniProt ID	Q06210

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCGIFAYLNY HVPRTRREIL ETLIKGLQRL EYRGYDSAGV GFDGGNDKDW EANACKIQLI
        70         80         90        100        110        120
KKKGKVKALD EEVHKQQDMD LDIEFDVHLG IAHTRWATHG EPSPVNSHPQ RSDKNNEFIV
       130        140        150        160        170        180
IHNGIITNYK DLKKFLESKG YDFESETDTE TIAKLVKYMY DNRESQDTSF TTLVERVIQQ
       190        200        210        220        230        240
LEGAFALVFK SVHFPGQAVG TRRGSPLLIG VRSEHKLSTD HIPILYRTAR TQIGSKFTRW
       250        260        270        280        290        300
GSQGERGKDK KGSCNLSRVD STTCLFPVEE KAVEYYFASD ASAVIEHTNR VIFLEDDDVA
       310        320        330        340        350        360
AVVDGRLSIH RIKRTAGDHP GRAVQTLQME LQQIMKGNFS SFMQKEIFEQ PESVVNTMRG
       370        380        390        400        410        420
RVNFDDYTVN LGGLKDHIKE IQRCRRLILI ACGTSYHAGV ATRQVLEELT ELPVMVELAS
       430        440        450        460        470        480
DFLDRNTPVF RDDVCFFLSQ SGETADTLMG LRYCKERGAL TVGITNTVGS SISRETDCGV
       490        500        510        520        530        540
HINAGPEIGV ASTKAYTSQF VSLVMFALMM CDDRISMQER RKEIMLGLKR LPDLIKEVLS
       550        560        570        580        590        600
MDDEIQKLAT ELYHQKSVLI MGRGYHYATC LEGALKIKEI TYMHSEGILA GELKHGPLAL
       610        620        630        640        650        660
VDKLMPVIMI IMRDHTYAKC QNALQQVVAR QGRPVVICDK EDTETIKNTK RTIKVPHSVD
       670        680        690
CLQGILSVIP LQLLAFHLAV LRGYDVDFPR NLAKSVTVE

Isoforms

- Isoform 2 of Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q06210-1-unknown	MCGIFA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75898
Q06210-2-unknown	CGIFAY...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q06210-2-unknown	CGIFAY...	2	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q06210-2-unknown	CGIFAY...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110510
Q06210-87-unknown	VHLGIA...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11927
Q06210-87-unknown	VHLGIA...	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141670

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DIEFDV	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11927
...DIEFDV	86	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124852
...SVTVE	699	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SVTVE	699	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71516

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	86	EFDV.\|.VHLG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)