Q07002: Cyclin-dependent kinase 18

General Information

Protein names	- Cyclin-dependent kinase 18 - 2.7.11.22 - Cell division protein kinase 18 - PCTAIRE-motif protein kinase 3 - Serine/threonine-protein kinase PCTAIRE-3
Gene names	CDK18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07002

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cyclin-dependent kinase 18 - Isoform 3 of Cyclin-dependent kinase 18 - Isoform 2 of Cyclin-dependent kinase 18

Sequence View

        10         20         30         40         50         60
MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNENLQLGPL GRDPPQECST
        70         80         90        100        110        120
FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP MDIRLPQEFL QKLQMESPDL
       130        140        150        160        170        180
PKPLSRMSRR ASLSDIGFGK LETYVKLDKL GEGTYATVFK GRSKLTENLV ALKEIRLEHE
       190        200        210        220        230        240
EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH
       250        260        270        280        290        300
NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE
       310        320        330        340        350        360
VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL HLIFRLLGTP
       370        380        390        400        410        420
TEETWPGVTA FSEFRTYSFP CYLPQPLINH APRLDTDGIH LLSSLLLYES KSRMSAEAAL
       430        440        450        460        470
SHSYFRSLGE RVHQLEDTAS IFSLKEIQLQ KDPGYRGLAF QQPGRGKNRR QSIF         10         20         30         40         50         60
MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNENLQLGPL GRDPPQECST
        70         80         90        100        110        120
FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP MDIRLPQEFL QKLQMESPDL
       130        140        150        160        170        180
PKPLSRMSRR ASLSDIGFGK LETYVKLDKL GEGTYATVFK GRSKLTENLV ALKEIRLEHE
       190        200        210        220        230        240
EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH
       250        260        270        280        290        300
NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE
       310        320        330        340        350        360
VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL HLIFRLLGTP
       370        380        390        400        410        420
TEETWPGVTA FSEFRTYSFP CYLPQPLINH APRLDTDGIH LLSSLLLYES KSRMSAEAAL
       430        440        450        460        470
SHSYFRSLGE RVHQLEDTAS IFSLKEIQLQ KDPGYRGLAF QQPGRGKNRR QSIF         10         20         30         40         50         60
MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNENLQLGPL GRDPPQECST
        70         80         90        100        110        120
FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP MDIRLPQEFL QKLQMESPDL
       130        140        150        160        170        180
PKPLSRMSRR ASLSDIGFGK LETYVKLDKL GEGTYATVFK GRSKLTENLV ALKEIRLEHE
       190        200        210        220        230        240
EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH
       250        260        270        280        290        300
NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE
       310        320        330        340        350        360
VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL HLIFRLLGTP
       370        380        390        400        410        420
TEETWPGVTA FSEFRTYSFP CYLPQPLINH APRLDTDGIH LLSSLLLYES KSRMSAEAAL
       430        440        450        460        470
SHSYFRSLGE RVHQLEDTAS IFSLKEIQLQ KDPGYRGLAF QQPGRGKNRR QSIF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q07002-1-unknown	MIMNKM...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q07002-1-unknown	MIMNKM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107372
Q07002-1-unknown	MIMNKM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107373
Q07002-1-unknown	MIMNKM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70099
Q07002-1-unknown	MIMNKM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70100
Q07002-169-unknown	LVALKE...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10209
Q07002-169-unknown	LVALKE...	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145579
Q07002-169-unknown	LVALKE...	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146613

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLTENL	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10209
...KLTENL	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128877
...KLTENL	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129920
...NRRQSI	472	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NRRQSI	472	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65717
...NRRQSI	472	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65718

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	168	TENL.\|.LVAL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)