Q09XV5: Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255|HAMAP-Rule:MF_03071}
| Protein names | - Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255|HAMAP-Rule:MF_03071} - CHD-8 {ECO:0000255|HAMAP-Rule:MF_03071} - 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03071} - ATP-dependent helicase CHD8 {ECO:0000255|HAMAP-Rule:MF_03071} - Axis duplication inhibitor - Duplin |
|---|---|
| Gene names | Chd8 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q09XV5 |
2
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN
70 80 90 100 110 120
SSASDLVPPP EETASTELPK ESTAPAPESL TLHDYTTQPT SQEQPAQPVL QTSTPTAGLL
130 140 150 160 170 180
QVSKSQEILS QGNPFMGVSA TGVSPSNTGG QPSQSAPKIV ILKAPPNSSV TGTHVAQIQA
190 200 210 220 230 240
QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLATKVPG NQAAVQRIVQ
250 260 270 280 290 300
PSRPVKQLVL QPVKGSAPAG NPGAAGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ
310 320 330 340 350 360
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS
370 380 390 400 410 420
QPQPQPQPPP SAQPLTLSSV QQAQIMGPGQ NPGQRLSVPL KMVLQPQAGS SQGASSGLSV
430 440 450 460 470 480
VKVLSASEVA ALSSPASCAP HTAGKTGMEE NRRLEHQKKQ EKANRIVAEA IARARARGEQ
490 500 510 520 530 540
NIPRVLNEDE LPSVRPEEEG EKKRRKKSSG ERLKEEKPKK SKTAAASKTK GKSKLNTITP
550 560 570 580 590 600
VVGKKRKRNT SSDNSDVEVM PAQSPREDEE SSIQKRRSNR QVKRKKYTED LDIKITDDEE
610 620 630 640 650 660
EEEVDVTGPI KPEPILPEPV QEPDGETLPS MQFFVENPSE EDAAIVDKVL SMRVVKKELP
670 680 690 700 710 720
SGQYTEAEEF FVKYKNYSYL HCEWATISQL EKDKRIHQKL KRFKTKMAQM RHFFHEDEEP
730 740 750 760 770 780
FNPDYVEVDR ILDESHSVDK DNGEPVIYYL VKWCSLPYED STWELKEDVD EGKIREFKRI
790 800 810 820 830 840
QSRHPELRRV NRPQANAWKK LELSHEYKNR NQLREYQLEG VNWLLFNWYN RQNCILADEM
850 860 870 880 890 900
GLGKTIQSIA FLQEVYNVGI HGPFLVIAPL STITNWEREF NTWTEMNTIV YHGSLASRQM
910 920 930 940 950 960
IQQYEMYCKD SRGRLIPGAY KFDALITTFE MILSDCPELR EIEWRCVIID EAHRLKNRNC
970 980 990 1000 1010 1020
KLLDSLKHMD LEHKVLLTGT PLQNTVEELF SLLHFLEPSQ FPSESEFLKD FGDLKTEEQV
1030 1040 1050 1060 1070 1080
QKLQAILKPM MLRRLKEDVE KNLAPKQETI IEVELTNIQK KYYRAILEKN FSFLSKGAGH
1090 1100 1110 1120 1130 1140
TNMPNLLNTM MELRKCCNHP YLINGAEEKI LMEFREACHI IPQDFHLQAM VRSAGKLVLI
1150 1160 1170 1180 1190 1200
DKLLPKLKAG GHKVLIFSQM VRCLDILEDY LIQRRYLYER IDGRVRGNLR QAAIDRFSKP
1210 1220 1230 1240 1250 1260
DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ AQARCHRIGQ SKAVKVYRLI
1270 1280 1290 1300 1310 1320
TRNSYEREMF DKASLKLGLD KAVLQSMSGR DGNITGIQQF SKKEIEDLLR KGAYAAIMEE
1330 1340 1350 1360 1370 1380
DDEGSKFCEE DIDQILLRRT TTITIESEGK GSTFAKASFV ASENRTDISL DDPNFWQKWA
1390 1400 1410 1420 1430 1440
KKADLDMDLL NSKNNLVIDT PRVRKQTRHF STLKDDDLVE FSDLESEDDE RPRSRRHDRH
1450 1460 1470 1480 1490 1500
HTYGRTDCFR VEKHLLVYGW GRWRDILSHG RFKRRMTERD VETICRAILV YCLLHYRGDE
1510 1520 1530 1540 1550 1560
NIKSFIWDLI SPAENGKTKE LQNHSGLSIP VPRGRKGKKV KSQSTFDIHK ADWIRKYNPD
1570 1580 1590 1600 1610 1620
TLFQDESYKK HLKHQCNKVL LRVRMLYYLR QEVIGDQAEK VLGGAIASEI DIWFPVVDQL
1630 1640 1650 1660 1670 1680
EVPTTWWDSE ADKSLLIGVF KHGYEKYNTM RADPALCFLE KAGRPDDKAI AAEHRVLDNF
1690 1700 1710 1720 1730 1740
SDLVEGIDFD KDCEDPEYKP LQGPPKDPDD EGDPLMMMDE EISVIDGEEA QVTQQPGHLF
1750 1760 1770 1780 1790 1800
WPPGSALTAR LRRLVTAYQR SYKREQMKME AAERGDRRRR RCEAAFKLKE IARREKQQRW
1810 1820 1830 1840 1850 1860
TRREQTDFYR VVSTFGVEYD PDNMQFHWDR FRTFARLDKK TDESLTKYFH GFVAMCRQVC
1870 1880 1890 1900 1910 1920
RLPPAAGDEP PDPNLFIEPI TEERASRTLY RIELLRRLRE QVLCHPLLED RLALCQPPGL
1930 1940 1950 1960 1970 1980
ELPKWWEPVR HDGELLRGAA RHGVSQTDCN IMQDPDFSFL AARMNYMQNH QAGASAASLS
1990 2000 2010 2020 2030 2040
RCSTPLLHQQ CTSRTASPSP LRPDAPVEKS PEESTVQVPN LESLTLKLED EVVARSRLTS
2050 2060 2070 2080 2090 2100
QDYEVRVGSS DTAPLSRSVP PVKLEDEDDS DSELDLSKLS PSSSSSSSSS SSSSSTDESE
2110 2120 2130 2140 2150 2160
DEKEEKLTAD RSRPKLYDEE SLLSLTMSQD GFPNEDGEQM TPELLLLQER QRASEWPKDR
2170 2180 2190 2200 2210 2220
VLINRIDLVC QAVLSGKWPS NRRSQEVTAG GILGPGNHLL DSPSLTPGED GDSPVPTPRS
2230 2240 2250 2260 2270 2280
GSAASMAEEE ASAVTTAAAQ FTKLRRGMDE KEFTVQIKDE EGLKLTFQKH RLMANGVMGD
2290 2300 2310 2320 2330 2340
GHPLFHKKKG NRKKLVELEV ECMEEPNHLD LDLETRIPVI NKVDGTLLVG DEAPRRAELE
2350 2360 2370 2380 2390 2400
MWLQGHPEFA VDPRFLAYME ERRKQKWQRC KKNNKAELNC LGMEPVQPAN SRNGKKGHYA
2410 2420 2430 2440 2450 2460
ETAFNRVLPG PVAPENSKKR VRRTRPDLSK MMALMQGGST GSLSLHNTFQ HSSSNLQSVS
2470 2480 2490 2500 2510 2520
SLGHSSTTSA SLPFMPFVMG AAAPPHVDSS TMLHHHHHHP HPHHHHHHHP GLRTTGYPSS
2530 2540 2550 2560 2570 2580
PATTTSGTAL RLPTLQPEDD DEEEDEEDDD LSQGYDSSER DFSLIDDPMM PANSDSSEDA
DD
Isoforms
- Isoform 2 of Chromodomain-helicase-DNA-binding protein 8Sequence View
10 20 30 40 50 60
MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN
70 80 90 100 110 120
SSASDLVPPP EETASTELPK ESTAPAPESL TLHDYTTQPT SQEQPAQPVL QTSTPTAGLL
130 140 150 160 170 180
QVSKSQEILS QGNPFMGVSA TGVSPSNTGG QPSQSAPKIV ILKAPPNSSV TGTHVAQIQA
190 200 210 220 230 240
QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLATKVPG NQAAVQRIVQ
250 260 270 280 290 300
PSRPVKQLVL QPVKGSAPAG NPGAAGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ
310 320 330 340 350 360
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS
370 380 390 400 410 420
QPQPQPQPPP SAQPLTLSSV QQAQIMGPGQ NPGQRLSVPL KMVLQPQAGS SQGASSGLSV
430 440 450 460 470 480
VKVLSASEVA ALSSPASCAP HTAGKTGMEE NRRLEHQKKQ EKANRIVAEA IARARARGEQ
490 500 510 520 530 540
NIPRVLNEDE LPSVRPEEEG EKKRRKKSSG ERLKEEKPKK SKTAAASKTK GKSKLNTITP
550 560 570 580 590 600
VVGKKRKRNT SSDNSDVEVM PAQSPREDEE SSIQKRRSNR QVKRKKYTED LDIKITDDEE
610 620 630 640 650 660
EEEVDVTGPI KPEPILPEPV QEPDGETLPS MQFFVENPSE EDAAIVDKVL SMRVVKKELP
670 680 690 700 710 720
SGQYTEAEEF FVKYKNYSYL HCEWATISQL EKDKRIHQKL KRFKTKMAQM RHFFHEDEEP
730 740 750 760 770 780
FNPDYVEVDR ILDESHSVDK DNGEPVIYYL VKWCSLPYED STWELKEDVD EGKIREFKRI
790 800 810 820 830 840
QSRHPELRRV NRPQANAWKK LELSHEYKNR NQLREYQLEG VNWLLFNWYN RQNCILADEM
850 860 870 880 890 900
GLGKTIQSIA FLQEVYNVGI HGPFLVIAPL STITNWEREF NTWTEMNTIV YHGSLASRQM
910 920 930 940 950 960
IQQYEMYCKD SRGRLIPGAY KFDALITTFE MILSDCPELR EIEWRCVIID EAHRLKNRNC
970 980 990 1000 1010 1020
KLLDSLKHMD LEHKVLLTGT PLQNTVEELF SLLHFLEPSQ FPSESEFLKD FGDLKTEEQV
1030 1040 1050 1060 1070 1080
QKLQAILKPM MLRRLKEDVE KNLAPKQETI IEVELTNIQK KYYRAILEKN FSFLSKGAGH
1090 1100 1110 1120 1130 1140
TNMPNLLNTM MELRKCCNHP YLINGAEEKI LMEFREACHI IPQDFHLQAM VRSAGKLVLI
1150 1160 1170 1180 1190 1200
DKLLPKLKAG GHKVLIFSQM VRCLDILEDY LIQRRYLYER IDGRVRGNLR QAAIDRFSKP
1210 1220 1230 1240 1250 1260
DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ AQARCHRIGQ SKAVKVYRLI
1270 1280 1290 1300 1310 1320
TRNSYEREMF DKASLKLGLD KAVLQSMSGR DGNITGIQQF SKKEIEDLLR KGAYAAIMEE
1330 1340 1350 1360 1370 1380
DDEGSKFCEE DIDQILLRRT TTITIESEGK GSTFAKASFV ASENRTDISL DDPNFWQKWA
1390 1400 1410 1420 1430 1440
KKADLDMDLL NSKNNLVIDT PRVRKQTRHF STLKDDDLVE FSDLESEDDE RPRSRRHDRH
1450 1460 1470 1480 1490 1500
HTYGRTDCFR VEKHLLVYGW GRWRDILSHG RFKRRMTERD VETICRAILV YCLLHYRGDE
1510 1520 1530 1540 1550 1560
NIKSFIWDLI SPAENGKTKE LQNHSGLSIP VPRGRKGKKV KSQSTFDIHK ADWIRKYNPD
1570 1580 1590 1600 1610 1620
TLFQDESYKK HLKHQCNKVL LRVRMLYYLR QEVIGDQAEK VLGGAIASEI DIWFPVVDQL
1630 1640 1650 1660 1670 1680
EVPTTWWDSE ADKSLLIGVF KHGYEKYNTM RADPALCFLE KAGRPDDKAI AAEHRVLDNF
1690 1700 1710 1720 1730 1740
SDLVEGIDFD KDCEDPEYKP LQGPPKDPDD EGDPLMMMDE EISVIDGEEA QVTQQPGHLF
1750 1760 1770 1780 1790 1800
WPPGSALTAR LRRLVTAYQR SYKREQMKME AAERGDRRRR RCEAAFKLKE IARREKQQRW
1810 1820 1830 1840 1850 1860
TRREQTDFYR VVSTFGVEYD PDNMQFHWDR FRTFARLDKK TDESLTKYFH GFVAMCRQVC
1870 1880 1890 1900 1910 1920
RLPPAAGDEP PDPNLFIEPI TEERASRTLY RIELLRRLRE QVLCHPLLED RLALCQPPGL
1930 1940 1950 1960 1970 1980
ELPKWWEPVR HDGELLRGAA RHGVSQTDCN IMQDPDFSFL AARMNYMQNH QAGASAASLS
1990 2000 2010 2020 2030 2040
RCSTPLLHQQ CTSRTASPSP LRPDAPVEKS PEESTVQVPN LESLTLKLED EVVARSRLTS
2050 2060 2070 2080 2090 2100
QDYEVRVGSS DTAPLSRSVP PVKLEDEDDS DSELDLSKLS PSSSSSSSSS SSSSSTDESE
2110 2120 2130 2140 2150 2160
DEKEEKLTAD RSRPKLYDEE SLLSLTMSQD GFPNEDGEQM TPELLLLQER QRASEWPKDR
2170 2180 2190 2200 2210 2220
VLINRIDLVC QAVLSGKWPS NRRSQEVTAG GILGPGNHLL DSPSLTPGED GDSPVPTPRS
2230 2240 2250 2260 2270 2280
GSAASMAEEE ASAVTTAAAQ FTKLRRGMDE KEFTVQIKDE EGLKLTFQKH RLMANGVMGD
2290 2300 2310 2320 2330 2340
GHPLFHKKKG NRKKLVELEV ECMEEPNHLD LDLETRIPVI NKVDGTLLVG DEAPRRAELE
2350 2360 2370 2380 2390 2400
MWLQGHPEFA VDPRFLAYME ERRKQKWQRC KKNNKAELNC LGMEPVQPAN SRNGKKGHYA
2410 2420 2430 2440 2450 2460
ETAFNRVLPG PVAPENSKKR VRRTRPDLSK MMALMQGGST GSLSLHNTFQ HSSSNLQSVS
2470 2480 2490 2500 2510 2520
SLGHSSTTSA SLPFMPFVMG AAAPPHVDSS TMLHHHHHHP HPHHHHHHHP GLRTTGYPSS
2530 2540 2550 2560 2570 2580
PATTTSGTAL RLPTLQPEDD DEEEDEEDDD LSQGYDSSER DFSLIDDPMM PANSDSSEDA
DD
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q09XV5-1-unknown | MADPIM... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q09XV5-1-unknown | MADPIM... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt70522 | |||
| Q09XV5-1281-unknown | KAVLQS... | 1281 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32425 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...KLGLDK | 1280 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32425 | |||
| ...EDADD | 2582 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_MOUSE | 1280 | GLDK.|.KAVL | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|