Q12874: Splicing factor 3A subunit 3

General Information

Protein names	- Splicing factor 3A subunit 3 - SF3a60 {ECO:0000303\|PubMed:11533230, ECO:0000303\|PubMed:21349847} - Spliceosome-associated protein 61 - SAP 61 {ECO:0000303\|PubMed:8022796}
Gene names	SF3A3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12874

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
METILEQQRR YHEEKERLMD VMAKEMLTKK STLRDQINSD HRTRAMQDRY MEVSGNLRDL
        70         80         90        100        110        120
YDDKDGLRKE ELNAISGPNE FAEFYNRLKQ IKEFHRKHPN EICVPMSVEF EELLKARENP
       130        140        150        160        170        180
SEEAQNLVEF TDEEGYGRYL DLHDCYLKYI NLKASEKLDY ITYLSIFDQL FDIPKERKNA
       190        200        210        220        230        240
EYKRYLEMLL EYLQDYTDRV KPLQDQNELF GKIQAEFEKK WENGTFPGWP KETSSALTHA
       250        260        270        280        290        300
GAHLDLSAFS SWEELASLGL DRLKSALLAL GLKCGGTLEE RAQRLFSTKG KSLESLDTSL
       310        320        330        340        350        360
FAKNPKSKGT KRDTERNKDI AFLEAQIYEY VEILGEQRHL THENVQRKQA RTGEEREEEE
       370        380        390        400        410        420
EEQISESESE DEENEIIYNP KNLPLGWDGK PIPYWLYKLH GLNINYNCEI CGNYTYRGPK
       430        440        450        460        470        480
AFQRHFAEWR HAHGMRCLGI PNTAHFANVT QIEDAVSLWA KLKLQKASER WQPDTEEEYE
       490        500
DSSGNVVNKK TYEDLKRQGL L

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q12874-1-Acetylation	METILE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12874-1-Acetylation	METILE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q12874-1-Acetylation	METILE...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q12874-1-Acetylation	METILE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q12874-66-	GLRKEE...	66			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q12874-107-unknown	SVEFEE...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14385
Q12874-165-	SIFDQL...	165			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...ICVPMS	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14385
	...RQGLL	501	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	106	VPMS.\|.SVEF	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)