Q12996: Cleavage stimulation factor subunit 3

General Information

Protein names	- Cleavage stimulation factor subunit 3 - CF-1 77 kDa subunit - Cleavage stimulation factor 77 kDa subunit - CSTF 77 kDa subunit - CstF-77
Gene names	CSTF3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12996

9 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cleavage stimulation factor subunit 3 - Isoform 3 of Cleavage stimulation factor subunit 3

Sequence View

        10         20         30         40         50         60
MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA RKTYERLVAQ
        70         80         90        100        110        120
FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL WKCYLSYVRE TKGKLPSYKE
       130        140        150        160        170        180
KMAQAYDFAL DKIGMEIMSY QIWVDYINFL KGVEAVGSYA ENQRITAVRR VYQRGCVNPM
       190        200        210        220        230        240
INIEQLWRDY NKYEEGINIH LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ
       250        260        270        280        290        300
NTPQEAQQVD MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY
       310        320        330        340        350        360
LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE ESRMKYEKVH
       370        380        390        400        410        420
SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK AREDTRTRHH VYVTAALMEY
       430        440        450        460        470        480
YCSKDKSVAF KIFELGLKKY GDIPEYVLAY IDYLSHLNED NNTRVLFERV LTSGSLPPEK
       490        500        510        520        530        540
SGEIWARFLA FESNIGDLAS ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE
       550        560        570        580        590        600
LKALGYKDVS RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP
       610        620        630        640        650        660
GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN TVEEAVRIIT
       670        680        690        700        710
GGAPELAVEG NGPVESNAVL TKAVKRPNED SDEDEEKGAV VPPVHDIYRA RQQKRIR         10         20         30         40         50         60
MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA RKTYERLVAQ
        70         80         90        100        110        120
FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL WKCYLSYVRE TKGKLPSYKE
       130        140        150        160        170        180
KMAQAYDFAL DKIGMEIMSY QIWVDYINFL KGVEAVGSYA ENQRITAVRR VYQRGCVNPM
       190        200        210        220        230        240
INIEQLWRDY NKYEEGINIH LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ
       250        260        270        280        290        300
NTPQEAQQVD MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY
       310        320        330        340        350        360
LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE ESRMKYEKVH
       370        380        390        400        410        420
SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK AREDTRTRHH VYVTAALMEY
       430        440        450        460        470        480
YCSKDKSVAF KIFELGLKKY GDIPEYVLAY IDYLSHLNED NNTRVLFERV LTSGSLPPEK
       490        500        510        520        530        540
SGEIWARFLA FESNIGDLAS ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE
       550        560        570        580        590        600
LKALGYKDVS RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP
       610        620        630        640        650        660
GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN TVEEAVRIIT
       670        680        690        700        710
GGAPELAVEG NGPVESNAVL TKAVKRPNED SDEDEEKGAV VPPVHDIYRA RQQKRIR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q12996-1-unknown	MSGDGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71945
Q12996-1-unknown	MSGDGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71946
Q12996-2-unknown	MSGDGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12996-2-Acetylation	SGDGAT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12996-2-Acetylation	SGDGAT...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q12996-2-Acetylation	SGDGAT...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110952
Q12996-2-Acetylation	SGDGAT...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110953
Q12996-5-unknown	GATEQA...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175983
Q12996-5-unknown	GATEQA...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175984
Q12996-5-	GATEQA...	5			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q12996-577-unknown	RKPEYP...	577			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q12996-577-	RKPEYP...	577			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q12996-678-unknown	AVLTKA...	678		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11996
Q12996-683-	AVKRPN...	683			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PVESNA	677	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11996
	...QKRIR	717	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	677	ESNA.\|.AVLT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)