Q13045: Protein flightless-1 homolog

General Information

Protein names	- Protein flightless-1 homolog
Gene names	FLII
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13045

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH
        70         80         90        100        110        120
LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP
       130        140        150        160        170        180
RELENAKNML VLNLSHNSID TIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV
       190        200        210        220        230        240
LNGNPLLHAQ LRQLPAMTAL QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE
       250        260        270        280        290        300
CLYTLPSLRR LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN
       310        320        330        340        350        360
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN HLVTLPEAIH
       370        380        390        400        410        420
FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL RLAGASPATV AAAAAAGSGP
       430        440        450        460        470        480
KDPMARKMRL RRRKDSAQDD QAKQVLKGMS DVAQEKNKKQ EESADARAPS GKVRRWDQGL
       490        500        510        520        530        540
EKPRLDYSEF FTEDVGQLPG LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS
       550        560        570        580        590        600
LNWEIYYWIG GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY
       610        620        630        640        650        660
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL DRGLDIYVWR
       670        680        690        700        710        720
GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP EFWEALGGEP SEIKKHVPED
       730        740        750        760        770        780
FWPPQPKLYK VGLGLGYLEL PQINYKLSVE HKQRPKVELM PRMRLLQSLL DTRCVYILDC
       790        800        810        820        830        840
WSDVFIWLGR KSPRLVRAAA LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD
       850        860        870        880        890        900
VLTVDYTRNA EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW
       910        920        930        940        950        960
NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE KKEDKEEKAE
       970        980        990       1000       1010       1020
GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF TFSLQKKFES LFPGKLEVVR
      1030       1040       1050       1060       1070       1080
MTQQQENPKF LSHFKRKFII HRGKRKAVQG AQQPSLYQIR TNGSALCTRC IQINTDSSLL
      1090       1100       1110       1120       1130       1140
NSEFCFILKV PFESEDNQGI VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP
      1150       1160       1170       1180       1190       1200
ENFFWVGIGA QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN
      1210       1220       1230       1240       1250       1260
GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE QHAFTRCFHA

WSAFCKALA

Isoforms

- Isoform 2 of Protein flightless-1 homolog - Isoform 3 of Protein flightless-1 homolog

Sequence View

        10         20         30         40         50         60
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH
        70         80         90        100        110        120
LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP
       130        140        150        160        170        180
RELENAKNML VLNLSHNSID TIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV
       190        200        210        220        230        240
LNGNPLLHAQ LRQLPAMTAL QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE
       250        260        270        280        290        300
CLYTLPSLRR LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN
       310        320        330        340        350        360
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN HLVTLPEAIH
       370        380        390        400        410        420
FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL RLAGASPATV AAAAAAGSGP
       430        440        450        460        470        480
KDPMARKMRL RRRKDSAQDD QAKQVLKGMS DVAQEKNKKQ EESADARAPS GKVRRWDQGL
       490        500        510        520        530        540
EKPRLDYSEF FTEDVGQLPG LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS
       550        560        570        580        590        600
LNWEIYYWIG GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY
       610        620        630        640        650        660
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL DRGLDIYVWR
       670        680        690        700        710        720
GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP EFWEALGGEP SEIKKHVPED
       730        740        750        760        770        780
FWPPQPKLYK VGLGLGYLEL PQINYKLSVE HKQRPKVELM PRMRLLQSLL DTRCVYILDC
       790        800        810        820        830        840
WSDVFIWLGR KSPRLVRAAA LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD
       850        860        870        880        890        900
VLTVDYTRNA EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW
       910        920        930        940        950        960
NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE KKEDKEEKAE
       970        980        990       1000       1010       1020
GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF TFSLQKKFES LFPGKLEVVR
      1030       1040       1050       1060       1070       1080
MTQQQENPKF LSHFKRKFII HRGKRKAVQG AQQPSLYQIR TNGSALCTRC IQINTDSSLL
      1090       1100       1110       1120       1130       1140
NSEFCFILKV PFESEDNQGI VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP
      1150       1160       1170       1180       1190       1200
ENFFWVGIGA QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN
      1210       1220       1230       1240       1250       1260
GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE QHAFTRCFHA

WSAFCKALA         10         20         30         40         50         60
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH
        70         80         90        100        110        120
LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP
       130        140        150        160        170        180
RELENAKNML VLNLSHNSID TIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV
       190        200        210        220        230        240
LNGNPLLHAQ LRQLPAMTAL QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE
       250        260        270        280        290        300
CLYTLPSLRR LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN
       310        320        330        340        350        360
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN HLVTLPEAIH
       370        380        390        400        410        420
FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL RLAGASPATV AAAAAAGSGP
       430        440        450        460        470        480
KDPMARKMRL RRRKDSAQDD QAKQVLKGMS DVAQEKNKKQ EESADARAPS GKVRRWDQGL
       490        500        510        520        530        540
EKPRLDYSEF FTEDVGQLPG LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS
       550        560        570        580        590        600
LNWEIYYWIG GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY
       610        620        630        640        650        660
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL DRGLDIYVWR
       670        680        690        700        710        720
GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP EFWEALGGEP SEIKKHVPED
       730        740        750        760        770        780
FWPPQPKLYK VGLGLGYLEL PQINYKLSVE HKQRPKVELM PRMRLLQSLL DTRCVYILDC
       790        800        810        820        830        840
WSDVFIWLGR KSPRLVRAAA LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD
       850        860        870        880        890        900
VLTVDYTRNA EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW
       910        920        930        940        950        960
NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE KKEDKEEKAE
       970        980        990       1000       1010       1020
GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF TFSLQKKFES LFPGKLEVVR
      1030       1040       1050       1060       1070       1080
MTQQQENPKF LSHFKRKFII HRGKRKAVQG AQQPSLYQIR TNGSALCTRC IQINTDSSLL
      1090       1100       1110       1120       1130       1140
NSEFCFILKV PFESEDNQGI VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP
      1150       1160       1170       1180       1190       1200
ENFFWVGIGA QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN
      1210       1220       1230       1240       1250       1260
GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE QHAFTRCFHA

WSAFCKALA

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13045-1-Acetylation	MEATGV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13045-1-Acetylation	MEATGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13045-1-Acetylation	MEATGV...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13045-1-Acetylation	MEATGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13045-1-Acetylation	MEATGV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96824
Q13045-1-unknown	MEATGV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75251
Q13045-447-unknown	KGMSDV...	447		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14398
Q13045-447-unknown	KGMSDV...	447		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151869
Q13045-447-unknown	KGMSDV...	447		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152570
Q13045-1047-	AVQGAQ...	1047			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13045-1047-unknown	AVQGAQ...	1047		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178179
Q13045-1047-unknown	AVQGAQ...	1047		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178178

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AKQVLK	446	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14398
...AKQVLK	446	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135274
...AKQVLK	446	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135986
...CKALA	1269	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CKALA	1269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70869
...CKALA	1269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70870

TopFIND

Q13045: Protein flightless-1 homolog

General Information

5

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates