Q13085: Acetyl-CoA carboxylase 1

General Information

Protein names	- Acetyl-CoA carboxylase 1 - ACC1 - 6.4.1.2 {ECO:0000269\|PubMed:20952656} - Acetyl-Coenzyme A carboxylase alpha - ACC-alpha - Biotin carboxylase - 6.3.4.14 {ECO:0000269\|PubMed:20952656}
Gene names	ACACA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13085

6 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVGSDTLS
        70         80         90        100        110        120
DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK
       130        140        150        160        170        180
VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG
       190        200        210        220        230        240
GPNNNNYANV ELILDIAKRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL
       250        260        270        280        290        300
GDKIASSIVA QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA
       310        320        330        340        350        360
AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV
       370        380        390        400        410        420
QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV FEHMEQCAVK LAKMVGYVSA
       430        440        450        460        470        480
GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY
       490        500        510        520        530        540
GVSPWGDSPI DFEDSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY
       550        560        570        580        590        600
FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET
       610        620        630        640        650        660
ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN FLHSLERGQV
       670        680        690        700        710        720
LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG
       730        740        750        760        770        780
SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVMRSPSAG KLIQYIVEDG GHVFAGQCYA
       790        800        810        820        830        840
EIEVMKMVMT LTAVESGCIH YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ
       850        860        870        880        890        900
STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSKVKD WVERLMKTLR DPSLPLLELQ
       910        920        930        940        950        960
DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV
       970        980        990       1000       1010       1020
FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD
      1030       1040       1050       1060       1070       1080
MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR
      1090       1100       1110       1120       1130       1140
ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH
      1150       1160       1170       1180       1190       1200
SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM
      1210       1220       1230       1240       1250       1260
SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFSDSP
      1270       1280       1290       1300       1310       1320
PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDRLAAMFRE FTQQNKATLV
      1330       1340       1350       1360       1370       1380
DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ
      1390       1400       1410       1420       1430       1440
LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE
      1450       1460       1470       1480       1490       1500
YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG
      1510       1520       1530       1540       1550       1560
SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA
      1570       1580       1590       1600       1610       1620
YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSTQA
      1630       1640       1650       1660       1670       1680
FLPSPPLPSD MLTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTFKSPE YPEGRDIIVI
      1690       1700       1710       1720       1730       1740
GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVSANS GARIGLAEEI RHMFHVAWVD
      1750       1760       1770       1780       1790       1800
PEDPYKGYRY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GIGPENLRGS
      1810       1820       1830       1840       1850       1860
GMIAGESSLA YNEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR
      1870       1880       1890       1900       1910       1920
EVYTSNNQLG GIQIMHNNGV THCTVCDDFE GVFTVLHWLS YMPKSVHSSV PLLNSKDPID
      1930       1940       1950       1960       1970       1980
RIIEFVPTKT PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG
      1990       2000       2010       2020       2030       2040
IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL
      2050       2060       2070       2080       2090       2100
MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECCQPVLV YIPPQAELRG GSWVVIDSSI
      2110       2120       2130       2140       2150       2160
NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSTAE
      2170       2180       2190       2200       2210       2220
RKELENKLKE REEFLIPIYH QVAVQFADLH DTPGRMQEKG VISDILDWKT SRTFFYWRLR
      2230       2240       2250       2260       2270       2280
RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL AEWLEKQLTE
      2290       2300       2310       2320       2330       2340
EDGVHSVIEE NIKCISRDYV LKQIRSLVQA NPEVAMDSII HMTQHISPTQ RAEVIRILST

MDSPST

Isoforms

- Isoform 2 of Acetyl-CoA carboxylase 1 - Isoform 3 of Acetyl-CoA carboxylase 1 - Isoform 4 of Acetyl-CoA carboxylase 1

Sequence View

        10         20         30         40         50         60
MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVGSDTLS
        70         80         90        100        110        120
DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK
       130        140        150        160        170        180
VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG
       190        200        210        220        230        240
GPNNNNYANV ELILDIAKRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL
       250        260        270        280        290        300
GDKIASSIVA QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA
       310        320        330        340        350        360
AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV
       370        380        390        400        410        420
QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV FEHMEQCAVK LAKMVGYVSA
       430        440        450        460        470        480
GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY
       490        500        510        520        530        540
GVSPWGDSPI DFEDSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY
       550        560        570        580        590        600
FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET
       610        620        630        640        650        660
ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN FLHSLERGQV
       670        680        690        700        710        720
LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG
       730        740        750        760        770        780
SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVMRSPSAG KLIQYIVEDG GHVFAGQCYA
       790        800        810        820        830        840
EIEVMKMVMT LTAVESGCIH YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ
       850        860        870        880        890        900
STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSKVKD WVERLMKTLR DPSLPLLELQ
       910        920        930        940        950        960
DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV
       970        980        990       1000       1010       1020
FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD
      1030       1040       1050       1060       1070       1080
MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR
      1090       1100       1110       1120       1130       1140
ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH
      1150       1160       1170       1180       1190       1200
SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM
      1210       1220       1230       1240       1250       1260
SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFSDSP
      1270       1280       1290       1300       1310       1320
PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDRLAAMFRE FTQQNKATLV
      1330       1340       1350       1360       1370       1380
DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ
      1390       1400       1410       1420       1430       1440
LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE
      1450       1460       1470       1480       1490       1500
YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG
      1510       1520       1530       1540       1550       1560
SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA
      1570       1580       1590       1600       1610       1620
YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSTQA
      1630       1640       1650       1660       1670       1680
FLPSPPLPSD MLTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTFKSPE YPEGRDIIVI
      1690       1700       1710       1720       1730       1740
GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVSANS GARIGLAEEI RHMFHVAWVD
      1750       1760       1770       1780       1790       1800
PEDPYKGYRY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GIGPENLRGS
      1810       1820       1830       1840       1850       1860
GMIAGESSLA YNEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR
      1870       1880       1890       1900       1910       1920
EVYTSNNQLG GIQIMHNNGV THCTVCDDFE GVFTVLHWLS YMPKSVHSSV PLLNSKDPID
      1930       1940       1950       1960       1970       1980
RIIEFVPTKT PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG
      1990       2000       2010       2020       2030       2040
IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL
      2050       2060       2070       2080       2090       2100
MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECCQPVLV YIPPQAELRG GSWVVIDSSI
      2110       2120       2130       2140       2150       2160
NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSTAE
      2170       2180       2190       2200       2210       2220
RKELENKLKE REEFLIPIYH QVAVQFADLH DTPGRMQEKG VISDILDWKT SRTFFYWRLR
      2230       2240       2250       2260       2270       2280
RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL AEWLEKQLTE
      2290       2300       2310       2320       2330       2340
EDGVHSVIEE NIKCISRDYV LKQIRSLVQA NPEVAMDSII HMTQHISPTQ RAEVIRILST

MDSPST         10         20         30         40         50         60
MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVGSDTLS
        70         80         90        100        110        120
DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK
       130        140        150        160        170        180
VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG
       190        200        210        220        230        240
GPNNNNYANV ELILDIAKRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL
       250        260        270        280        290        300
GDKIASSIVA QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA
       310        320        330        340        350        360
AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV
       370        380        390        400        410        420
QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV FEHMEQCAVK LAKMVGYVSA
       430        440        450        460        470        480
GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY
       490        500        510        520        530        540
GVSPWGDSPI DFEDSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY
       550        560        570        580        590        600
FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET
       610        620        630        640        650        660
ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN FLHSLERGQV
       670        680        690        700        710        720
LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG
       730        740        750        760        770        780
SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVMRSPSAG KLIQYIVEDG GHVFAGQCYA
       790        800        810        820        830        840
EIEVMKMVMT LTAVESGCIH YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ
       850        860        870        880        890        900
STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSKVKD WVERLMKTLR DPSLPLLELQ
       910        920        930        940        950        960
DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV
       970        980        990       1000       1010       1020
FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD
      1030       1040       1050       1060       1070       1080
MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR
      1090       1100       1110       1120       1130       1140
ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH
      1150       1160       1170       1180       1190       1200
SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM
      1210       1220       1230       1240       1250       1260
SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFSDSP
      1270       1280       1290       1300       1310       1320
PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDRLAAMFRE FTQQNKATLV
      1330       1340       1350       1360       1370       1380
DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ
      1390       1400       1410       1420       1430       1440
LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE
      1450       1460       1470       1480       1490       1500
YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG
      1510       1520       1530       1540       1550       1560
SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA
      1570       1580       1590       1600       1610       1620
YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSTQA
      1630       1640       1650       1660       1670       1680
FLPSPPLPSD MLTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTFKSPE YPEGRDIIVI
      1690       1700       1710       1720       1730       1740
GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVSANS GARIGLAEEI RHMFHVAWVD
      1750       1760       1770       1780       1790       1800
PEDPYKGYRY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GIGPENLRGS
      1810       1820       1830       1840       1850       1860
GMIAGESSLA YNEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR
      1870       1880       1890       1900       1910       1920
EVYTSNNQLG GIQIMHNNGV THCTVCDDFE GVFTVLHWLS YMPKSVHSSV PLLNSKDPID
      1930       1940       1950       1960       1970       1980
RIIEFVPTKT PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG
      1990       2000       2010       2020       2030       2040
IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL
      2050       2060       2070       2080       2090       2100
MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECCQPVLV YIPPQAELRG GSWVVIDSSI
      2110       2120       2130       2140       2150       2160
NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSTAE
      2170       2180       2190       2200       2210       2220
RKELENKLKE REEFLIPIYH QVAVQFADLH DTPGRMQEKG VISDILDWKT SRTFFYWRLR
      2230       2240       2250       2260       2270       2280
RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL AEWLEKQLTE
      2290       2300       2310       2320       2330       2340
EDGVHSVIEE NIKCISRDYV LKQIRSLVQA NPEVAMDSII HMTQHISPTQ RAEVIRILST

MDSPST         10         20         30         40         50         60
MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS PASVGSDTLS
        70         80         90        100        110        120
DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF TVASPAEFVT RFGGNKVIEK
       130        140        150        160        170        180
VLIANNGIAA VKCMRSIRRW SYEMFRNERA IRFVVMVTPE DLKANAEYIK MADHYVPVPG
       190        200        210        220        230        240
GPNNNNYANV ELILDIAKRI PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL
       250        260        270        280        290        300
GDKIASSIVA QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA
       310        320        330        340        350        360
AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR LAKQSRHLEV
       370        380        390        400        410        420
QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV FEHMEQCAVK LAKMVGYVSA
       430        440        450        460        470        480
GTVEYLYSQD GSFYFLELNP RLQVEHPCTE MVADVNLPAA QLQIAMGIPL YRIKDIRMMY
       490        500        510        520        530        540
GVSPWGDSPI DFEDSAHVPC PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY
       550        560        570        580        590        600
FSVAAAGGLH EFADSQFGHC FSWGENREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET
       610        620        630        640        650        660
ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN FLHSLERGQV
       670        680        690        700        710        720
LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS CVEVDVHRLS DGGLLLSYDG
       730        740        750        760        770        780
SSYTTYMKEE VDRYRITIGN KTCVFEKEND PSVMRSPSAG KLIQYIVEDG GHVFAGQCYA
       790        800        810        820        830        840
EIEVMKMVMT LTAVESGCIH YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ
       850        860        870        880        890        900
STALRGEKLH RVFHYVLDNL VNVMNGYCLP DPFFSSKVKD WVERLMKTLR DPSLPLLELQ
       910        920        930        940        950        960
DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA TLNRKSEREV
       970        980        990       1000       1010       1020
FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ FQNGHYDKCV FALREENKSD
      1030       1040       1050       1060       1070       1080
MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG RDPTLTDELL NILTELTQLS KTTNAKVALR
      1090       1100       1110       1120       1130       1140
ARQVLIASHL PSYELRHNQV ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH
      1150       1160       1170       1180       1190       1200
SNQVVRMAAL EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM
      1210       1220       1230       1240       1250       1260
SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD EVMGCFSDSP
      1270       1280       1290       1300       1310       1320
PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE DDRLAAMFRE FTQQNKATLV
      1330       1340       1350       1360       1370       1380
DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ
      1390       1400       1410       1420       1430       1440
LELNRMRNFD LTAIPCANHK MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE
      1450       1460       1470       1480       1490       1500
YLQNEGERLL LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRSMVMRYG
      1510       1520       1530       1540       1550       1560
SRLWKLRVLQ AELKINIRLT PTGKAIPIRL FLTNESGYYL DISLYKEVTD SRTAQIMFQA
      1570       1580       1590       1600       1610       1620
YGDKQGPLHG MLINTPYVTK DLLQSKRFQA QSLGTTYIYD IPEMFRQSLI KLWESMSTQA
      1630       1640       1650       1660       1670       1680
FLPSPPLPSD MLTYTELVLD DQGQLVHMNR LPGGNEIGMV AWKMTFKSPE YPEGRDIIVI
      1690       1700       1710       1720       1730       1740
GNDITYRIGS FGPQEDLLFL RASELARAEG IPRIYVSANS GARIGLAEEI RHMFHVAWVD
      1750       1760       1770       1780       1790       1800
PEDPYKGYRY LYLTPQDYKR VSALNSVHCE HVEDEGESRY KITDIIGKEE GIGPENLRGS
      1810       1820       1830       1840       1850       1860
GMIAGESSLA YNEIITISLV TCRAIGIGAY LVRLGQRTIQ VENSHLILTG AGALNKVLGR
      1870       1880       1890       1900       1910       1920
EVYTSNNQLG GIQIMHNNGV THCTVCDDFE GVFTVLHWLS YMPKSVHSSV PLLNSKDPID
      1930       1940       1950       1960       1970       1980
RIIEFVPTKT PYDPRWMLAG RPHPTQKGQW LSGFFDYGSF SEIMQPWAQT VVVGRARLGG
      1990       2000       2010       2020       2030       2040
IPVGVVAVET RTVELSIPAD PANLDSEAKI IQQAGQVWFP DSAFKTYQAI KDFNREGLPL
      2050       2060       2070       2080       2090       2100
MVFANWRGFS GGMKDMYDQV LKFGAYIVDG LRECCQPVLV YIPPQAELRG GSWVVIDSSI
      2110       2120       2130       2140       2150       2160
NPRHMEMYAD RESRGSVLEP EGTVEIKFRR KDLVKTMRRV DPVYIHLAER LGTPELSTAE
      2170       2180       2190       2200       2210       2220
RKELENKLKE REEFLIPIYH QVAVQFADLH DTPGRMQEKG VISDILDWKT SRTFFYWRLR
      2230       2240       2250       2260       2270       2280
RLLLEDLVKK KIHNANPELT DGQIQAMLRR WFVEVEGTVK AYVWDNNKDL AEWLEKQLTE
      2290       2300       2310       2320       2330       2340
EDGVHSVIEE NIKCISRDYV LKQIRSLVQA NPEVAMDSII HMTQHISPTQ RAEVIRILST

MDSPST

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q13085-1-Acetylation	MDEPSP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13085-1-Acetylation	MDEPSP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99141
Q13085-37-unknown	VKLDLL...	37		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12001
Q13085-37-unknown	VKLDLL...	37		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140926
Q13085-79-unknown	MSGLHL...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66088
Q13085-79-unknown	MSGLHL...	79		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000335323
Q13085-79-unknown	MSGLHL...	79		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464763
Q13085-79-unknown	MSGLHL...	79		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000377925
Q13085-79-unknown	MSGLHL...	79		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391737
Q13085-79-unknown	MSGLHL...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt98116
Q13085-79-unknown	MSGLHL...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt98115
Q13085-79-unknown	MSGLHL...	79		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13085-79-unknown	MSGLHL...	79		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q13085-1300-unknown	EDDRLA...	1300		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467820
Q13085-1300-unknown	EDDRLA...	1300		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200651
Q13085-1300-unknown	EDDRLA...	1300		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200652
Q13085-1300-unknown	EDDRLA...	1300		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200650
Q13085-1550-unknown	DSRTAQ...	1550		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465478
Q13085-1550-unknown	DSRTAQ...	1550		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200741
Q13085-1550-unknown	DSRTAQ...	1550		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200742
Q13085-1550-unknown	DSRTAQ...	1550		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200740
Q13085-1875-unknown	MHNNGV...	1875		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000354565
Q13085-1875-unknown	MHNNGV...	1875		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200803
Q13085-1875-unknown	MHNNGV...	1875		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200804
Q13085-1875-unknown	MHNNGV...	1875		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200802

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EISNLV	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12001
...EISNLV	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124070
...KVIEKV	120	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000377925
...KVIEKV	120	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397282
...KVIEKV	120	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000391737
...KVIEKV	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154593
...KVIEKV	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154594
...KVIEKV	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154592
...YIKMAD	172	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464763
...YIKMAD	172	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155285
...YIKMAD	172	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155286
...YIKMAD	172	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155284
...DSPST	2346	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DSPST	2346	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt61706
...DSPST	2346	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt61705
...DSPST	2346	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt61707
...DSPST	2346		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSPST	2346		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DSPST	2346		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSPST	2346		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

TopFIND

Q13085: Acetyl-CoA carboxylase 1

General Information

6

N-termini

5

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates