Q13144: Translation initiation factor eIF-2B subunit epsilon

General Information

Protein names	- Translation initiation factor eIF-2B subunit epsilon - eIF-2B GDP-GTP exchange factor subunit epsilon
Gene names	EIF2B5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13144

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAPVVAPPG VVVSRANKRS GAGPGGSGGG GARGAEEEPP PPLQAVLVAD SFDRRFFPIS
        70         80         90        100        110        120
KDQPRVLLPL ANVALIDYTL EFLTATGVQE TFVFCCWKAA QIKEHLLKSK WCRPTSLNVV
       130        140        150        160        170        180
RIITSELYRS LGDVLRDVDA KALVRSDFLL VYGDVISNIN ITRALEEHRL RRKLEKNVSV
       190        200        210        220        230        240
MTMIFKESSP SHPTRCHEDN VVVAVDSTTN RVLHFQKTQG LRRFAFPLSL FQGSSDGVEV
       250        260        270        280        290        300
RYDLLDCHIS ICSPQVAQLF TDNFDYQTRD DFVRGLLVNE EILGNQIHMH VTAKEYGARV
       310        320        330        340        350        360
SNLHMYSAVC ADVIRRWVYP LTPEANFTDS TTQSCTHSRH NIYRGPEVSL GHGSILEENV
       370        380        390        400        410        420
LLGSGTVIGS NCFITNSVIG PGCHIGDNVV LDQTYLWQGV RVAAGAQIHQ SLLCDNAEVK
       430        440        450        460        470        480
ERVTLKPRSV LTSQVVVGPN ITLPEGSVIS LHPPDAEEDE DDGEFSDDSG ADQEKDKVKM
       490        500        510        520        530        540
KGYNPAEVGA AGKGYLWKAA GMNMEEEEEL QQNLWGLKIN MEEESESESE QSMDSEEPDS
       550        560        570        580        590        600
RGGSPQMDDI KVFQNEVLGT LQRGKEENIS CDNLVLEINS LKYAYNISLK EVMQVLSHVV
       610        620        630        640        650        660
LEFPLQQMDS PLDSSRYCAL LLPLLKAWSP VFRNYIKRAA DHLEALAAIE DFFLEHEALG
       670        680        690        700        710        720
ISMAKVLMAF YQLEILAEET ILSWFSQRDT TDKGQQLRKN QQLQRFIQWL KEAEEESSED

D

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13144-2-unknown	MAAPVV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13144-2-Acetylation	AAPVVA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13144-2-Acetylation	AAPVVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13144-2-Acetylation	AAPVVA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13144-2-Acetylation	AAPVVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13144-573-unknown	NLVLEI...	573		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12005

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KEHLLK	107	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414775
...NISCDN	572	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12005
...SSEDD	721	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	572	SCDN.\|.NLVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)