Q13162: Peroxiredoxin-4

General Information

Protein names	- Peroxiredoxin-4 - 1.11.1.15 {ECO:0000269\|PubMed:21916849, ECO:0000269\|PubMed:9388242} - Antioxidant enzyme AOE372 - AOE37-2 - Peroxiredoxin IV - Prx-IV - Thioredoxin peroxidase AO372 - Thioredoxin-dependent peroxide reductase A0372
Gene names	PRDX4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13162

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEALPLLAAT TPDHGRHRRL LLLPLLLFLL PAGAVQGWET EERPRTREEE CHFYAGGQVY
        70         80         90        100        110        120
PGEASRVSVA DHSLHLSKAK ISKPAPYWEG TAVIDGEFKE LKLTDYRGKY LVFFFYPLDF
       130        140        150        160        170        180
TFVCPTEIIA FGDRLEEFRS INTEVVACSV DSQFTHLAWI NTPRRQGGLG PIRIPLLSDL
       190        200        210        220        230        240
THQISKDYGV YLEDSGHTLR GLFIIDDKGI LRQITLNDLP VGRSVDETLR LVQAFQYTDK
       250        260        270
HGEVCPAGWK PGSETIIPDP AGKLKYFDKL N

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13162-35-	VQGWET...	35		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13162-35-	VQGWET...	35		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13162-35-	VQGWET...	35		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13162-35-	VQGWET...	35		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13162-35-	VQGWET...	35		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13162-38-	WETEER...	38		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13162-38-unknown	WETEER...	38	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13162-81-unknown	ISKPAP...	81	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q13162-215-unknown	TLNDLP...	215		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SGHTLR	199	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000368654
	...FDKLN	271	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)