Q13322: Growth factor receptor-bound protein 10

General Information

Protein names	- Growth factor receptor-bound protein 10 - GRB10 adapter protein - Insulin receptor-binding protein Grb-IR
Gene names	GRB10
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13322

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Growth factor receptor-bound protein 10 - Isoform 2 of Growth factor receptor-bound protein 10 - Isoform 4 of Growth factor receptor-bound protein 10

Sequence View

        10         20         30         40         50         60
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN
        70         80         90        100        110        120
ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV
       130        140        150        160        170        180
RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK
       190        200        210        220        230        240
VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE
       250        260        270        280        290        300
SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK
       310        320        330        340        350        360
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH
       370        380        390        400        410        420
GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF
       430        440        450        460        470        480
STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP
       490        500        510        520        530        540
STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK
       550        560        570        580        590
NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL         10         20         30         40         50         60
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN
        70         80         90        100        110        120
ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV
       130        140        150        160        170        180
RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK
       190        200        210        220        230        240
VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE
       250        260        270        280        290        300
SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK
       310        320        330        340        350        360
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH
       370        380        390        400        410        420
GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF
       430        440        450        460        470        480
STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP
       490        500        510        520        530        540
STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK
       550        560        570        580        590
NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL         10         20         30         40         50         60
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN
        70         80         90        100        110        120
ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV
       130        140        150        160        170        180
RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK
       190        200        210        220        230        240
VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE
       250        260        270        280        290        300
SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK
       310        320        330        340        350        360
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH
       370        380        390        400        410        420
GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF
       430        440        450        460        470        480
STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP
       490        500        510        520        530        540
STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK
       550        560        570        580        590
NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13322-1-unknown	MALAGC...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13322-1-unknown	MALAGC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76397
Q13322-59-unknown	MNASLE...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76398
Q13322-59-unknown	MNASLE...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102132
Q13322-59-unknown	MNASLE...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102133
Q13322-436-unknown	DFSGQT...	436	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14411
Q13322-436-unknown	DFSGQT...	436	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151571
Q13322-436-unknown	DFSGQT...	436	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151837
Q13322-436-unknown	DFSGQT...	436	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152467

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SLVAMD	435	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14411
...SLVAMD	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134976
...SLVAMD	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135243
...SLVAMD	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135878
...IRVAL	594	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IRVAL	594	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72016
...IRVAL	594	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72015
...IRVAL	594	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72017

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	435	VAMD.\|.DFSG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)