TopFIND 4.0

Q13356: RING-type E3 ubiquitin-protein ligase PPIL2 {ECO:0000305}

General Information

Protein names
- RING-type E3 ubiquitin-protein ligase PPIL2 {ECO:0000305}
- 2.3.2.27 {ECO:0000269|PubMed:11435423}
- CYC4 {ECO:0000303|PubMed:11435423}
- Cyclophilin-60 {ECO:0000303|PubMed:8660300}
- Cyclophilin-like protein Cyp-60 {ECO:0000303|PubMed:8660300}
- Cyp60 {ECO:0000303|PubMed:8660300}
- hCyP-60 {ECO:0000303|PubMed:8660300}
- Probable inactive peptidyl-prolyl cis-trans isomerase-like 2 {ECO:0000305|PubMed:20676357}
- PPIase {ECO:0000305|PubMed:20676357}
- Rotamase PPIL2 {ECO:0000305}
Gene names PPIL2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q13356

5

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV 
        70         80         90        100        110        120 
FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR 
       130        140        150        160        170        180 
TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK 
       190        200        210        220        230        240 
IIDPDEEKAK QDPSYYLKNT NAETRETLQE LYKEFKGDEI LAATMKAPEK KKVDKLNAAH 
       250        260        270        280        290        300 
YSTGKVSASF TSTAMVPETT HEAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT 
       310        320        330        340        350        360 
PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH 
       370        380        390        400        410        420 
TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD 
       430        440        450        460        470        480 
RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV 
       490        500        510        520    
GKYINPAATK RAAEEEPSTS ATVPMSKKKP SRGFGDFSSW 

Isoforms

- Isoform 2 of Peptidyl-prolyl cis-trans isomerase-like 2 - Isoform 2 of RING-type E3 ubiquitin-protein ligase PPIL2

Sequence View

        10         20         30         40         50         60 
MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV 
        70         80         90        100        110        120 
FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR 
       130        140        150        160        170        180 
TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK 
       190        200        210        220        230        240 
IIDPDEEKAK QDPSYYLKNT NAETRETLQE LYKEFKGDEI LAATMKAPEK KKVDKLNAAH 
       250        260        270        280        290        300 
YSTGKVSASF TSTAMVPETT HEAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT 
       310        320        330        340        350        360 
PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH 
       370        380        390        400        410        420 
TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD 
       430        440        450        460        470        480 
RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV 
       490        500        510        520    
GKYINPAATK RAAEEEPSTS ATVPMSKKKP SRGFGDFSSW          10         20         30         40         50         60 
MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV 
        70         80         90        100        110        120 
FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR 
       130        140        150        160        170        180 
TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK 
       190        200        210        220        230        240 
IIDPDEEKAK QDPSYYLKNT NAETRETLQE LYKEFKGDEI LAATMKAPEK KKVDKLNAAH 
       250        260        270        280        290        300 
YSTGKVSASF TSTAMVPETT HEAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT 
       310        320        330        340        350        360 
PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH 
       370        380        390        400        410        420 
TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD 
       430        440        450        460        470        480 
RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV 
       490        500        510        520    
GKYINPAATK RAAEEEPSTS ATVPMSKKKP SRGFGDFSSW 



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DFSSW 520 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)