Q13362: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

General Information

Protein names	- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform - PP2A B subunit isoform B'-gamma - PP2A B subunit isoform B56-gamma - PP2A B subunit isoform PR61-gamma - PP2A B subunit isoform R5-gamma - Renal carcinoma antigen NY-REN-29
Gene names	PPP2R5C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13362

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform - Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform - Isoform 4 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform - Isoform 5 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Sequence View

        10         20         30         40         50         60
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL
        70         80         90        100        110        120
SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP
       130        140        150        160        170        180
EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD
       190        200        210        220        230        240
FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK
       250        260        270        280        290        300
EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK
       310        320        330        340        350        360
EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS
       370        380        390        400        410        420
DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK
       430        440        450        460        470        480
LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH
       490        500        510        520
QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR         10         20         30         40         50         60
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL
        70         80         90        100        110        120
SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP
       130        140        150        160        170        180
EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD
       190        200        210        220        230        240
FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK
       250        260        270        280        290        300
EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK
       310        320        330        340        350        360
EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS
       370        380        390        400        410        420
DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK
       430        440        450        460        470        480
LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH
       490        500        510        520
QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR         10         20         30         40         50         60
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL
        70         80         90        100        110        120
SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP
       130        140        150        160        170        180
EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD
       190        200        210        220        230        240
FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK
       250        260        270        280        290        300
EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK
       310        320        330        340        350        360
EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS
       370        380        390        400        410        420
DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK
       430        440        450        460        470        480
LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH
       490        500        510        520
QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR         10         20         30         40         50         60
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL
        70         80         90        100        110        120
SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP
       130        140        150        160        170        180
EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD
       190        200        210        220        230        240
FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK
       250        260        270        280        290        300
EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK
       310        320        330        340        350        360
EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS
       370        380        390        400        410        420
DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK
       430        440        450        460        470        480
LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH
       490        500        510        520
QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13362-1-Acetylation	MLTCNK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13362-1-Acetylation	MLTCNK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13362-1-Acetylation	MLTCNK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100978
Q13362-1-Acetylation	MLTCNK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100979
Q13362-1-unknown	MLTCNK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65734
Q13362-1-unknown	MLTCNK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65735
Q13362-12-unknown	VVDAAN...	12		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164525
Q13362-12-unknown	VVDAAN...	12		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164526
Q13362-12-	VVDAAN...	12			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13362-12-	VVDAAN...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13362-12-	VVDAAN...	12			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13362-15-	AANSNG...	15			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13362-15-	AANSNG...	15			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13362-15-	AANSNG...	15			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13362-15-unknown	AANSNG...	15			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13362-15-unknown	AANSNG...	15		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161238
Q13362-15-unknown	AANSNG...	15		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161239

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SQDGR	524	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SQDGR	524	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61353
...SQDGR	524	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61354
...SQDGR	524	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61355

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)