Q13426: DNA repair protein XRCC4

General Information

Protein names	- DNA repair protein XRCC4 - X-ray repair cross-complementing protein 4
Gene names	XRCC4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13426

3 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of DNA repair protein XRCC4 - Isoform 3 of DNA repair protein XRCC4

Sequence View

        10         20         30         40         50         60
MERKISRIHL VSEPSITHFL QVSWEKTLES GFVITLTDGH SAWTGTVSES EISQEADDMA
        70         80         90        100        110        120
MEKGKYVGEL RKALLSGAGP ADVYTFNFSK ESCYFFFEKN LKDVSFRLGS FNLEKVENPA
       130        140        150        160        170        180
EVIRELICYC LDTIAENQAK NEHLQKENER LLRDWNDVQG RFEKCVSAKE ALETDLYKRF
       190        200        210        220        230        240
ILVLNEKKTK IRSLHNKLLN AAQEREKDIK QEGETAICSE MTADRDPVYD ESTDEESENQ
       250        260        270        280        290        300
TDLSGLASAA VSKDDSIISS LDVTDIAPSR KRRQRMQRNL GTEPKMAPQE NQLQEKENSR
       310        320        330
PDSSLPETSK KEHISAENMS LETLRNSSPE DLFDEI         10         20         30         40         50         60
MERKISRIHL VSEPSITHFL QVSWEKTLES GFVITLTDGH SAWTGTVSES EISQEADDMA
        70         80         90        100        110        120
MEKGKYVGEL RKALLSGAGP ADVYTFNFSK ESCYFFFEKN LKDVSFRLGS FNLEKVENPA
       130        140        150        160        170        180
EVIRELICYC LDTIAENQAK NEHLQKENER LLRDWNDVQG RFEKCVSAKE ALETDLYKRF
       190        200        210        220        230        240
ILVLNEKKTK IRSLHNKLLN AAQEREKDIK QEGETAICSE MTADRDPVYD ESTDEESENQ
       250        260        270        280        290        300
TDLSGLASAA VSKDDSIISS LDVTDIAPSR KRRQRMQRNL GTEPKMAPQE NQLQEKENSR
       310        320        330
PDSSLPETSK KEHISAENMS LETLRNSSPE DLFDEI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13426-1-unknown	MERKIS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13426-1-unknown	MERKIS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94744
Q13426-1-unknown	MERKIS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94745
Q13426-255-unknown	DSIISS...	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12021
Q13426-255-unknown	DSIISS...	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148665
Q13426-255-unknown	DSIISS...	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148666
Q13426-266-unknown	IAPSRK...	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2173
Q13426-266-unknown	IAPSRK...	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149021
Q13426-266-unknown	IAPSRK...	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149022

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...AVSKDD	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12021
...AVSKDD	254	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132040
...AVSKDD	254	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132041
...LDVTDI	265	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2173
...LDVTDI	265	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132404
...LDVTDI	265	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132405
...LFDEI	336		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LFDEI	336		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LFDEI	336	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LFDEI	336	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt90362
...LFDEI	336		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LFDEI	336		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	254	SKDD.\|.DSII	inferred from experiment	unknown	MEROPS	Dynan WS	Lee KJ et al.:Identification of human autoant... (C14.003)	12218164,
CASP3_HUMAN	265	VTDI.\|.IAPS	inferred from experiment	unknown	MEROPS	Dynan WS	Lee KJ et al.:Identification of human autoant... (C14.003)	12218164,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)