Q13469: Nuclear factor of activated T-cells, cytoplasmic 2

General Information

Protein names	- Nuclear factor of activated T-cells, cytoplasmic 2 - NF-ATc2 - NFATc2 - NFAT pre-existing subunit - NF-ATp - T-cell transcription factor NFAT1
Gene names	NFATC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13469

11 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear factor of activated T-cells, cytoplasmic 2 - Isoform 3 of Nuclear factor of activated T-cells, cytoplasmic 2 - Isoform 4 of Nuclear factor of activated T-cells, cytoplasmic 2 - Isoform 5 of Nuclear factor of activated T-cells, cytoplasmic 2

Sequence View

        10         20         30         40         50         60
MNAPERQPQP DGGDAPGHEP GGSPQDELDF SILFDYEYLN PNEEEPNAHK VASPPSGPAY
        70         80         90        100        110        120
PDDVLDYGLK PYSPLASLSG EPPGRFGEPD RVGPQKFLSA AKPAGASGLS PRIEITPSHE
       130        140        150        160        170        180
LIQAVGPLRM RDAGLLVEQP PLAGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS
       190        200        210        220        230        240
DTFSPYTSPC VSPNNGGPDD LCPQFQNIPA HYSPRTSPIM SPRTSLAEDS CLGRHSPVPR
       250        260        270        280        290        300
PASRSSSPGA KRRHSCAEAL VALPPGASPQ RSRSPSPQPS SHVAPQDHGS PAGYPPVAGS
       310        320        330        340        350        360
AVIMDALNSL ATDSPCGIPP KMWKTSPDPS PVSAAPSKAG LPRHIYPAVE FLGPCEQGER
       370        380        390        400        410        420
RNSAPESILL VPPTWPKPLV PAIPICSIPV TASLPPLEWP LSSQSGSYEL RIEVQPKPHH
       430        440        450        460        470        480
RAHYETEGSR GAVKAPTGGH PVVQLHGYME NKPLGLQIFI GTADERILKP HAFYQVHRIT
       490        500        510        520        530        540
GKTVTTTSYE KIVGNTKVLE IPLEPKNNMR ATIDCAGILK LRNADIELRK GETDIGRKNT
       550        560        570        580        590        600
RVRLVFRVHI PESSGRIVSL QTASNPIECS QRSAHELPMV ERQDTDSCLV YGGQQMILTG
       610        620        630        640        650        660
QNFTSESKVV FTEKTTDGQQ IWEMEATVDK DKSQPNMLFV EIPEYRNKHI RTPVKVNFYV
       670        680        690        700        710        720
INGKRKRSQP QHFTYHPVPA IKTEPTDEYD PTLICSPTHG GLGSQPYYPQ HPMVAESPSC
       730        740        750        760        770        780
LVATMAPCQQ FRTGLSSPDA RYQQQNPAAV LYQRSKSLSP SLLGYQQPAL MAAPLSLADA
       790        800        810        820        830        840
HRSVLVHAGS QGQSSALLHP SPTNQQASPV IHYSPTNQQL RCGSHQEFQH IMYCENFAPG
       850        860        870        880        890        900
TTRPGPPPVS QGQRLSPGSY PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL
       910        920
DQTYLDDVNE IIRKEFSGPP ARNQT         10         20         30         40         50         60
MNAPERQPQP DGGDAPGHEP GGSPQDELDF SILFDYEYLN PNEEEPNAHK VASPPSGPAY
        70         80         90        100        110        120
PDDVLDYGLK PYSPLASLSG EPPGRFGEPD RVGPQKFLSA AKPAGASGLS PRIEITPSHE
       130        140        150        160        170        180
LIQAVGPLRM RDAGLLVEQP PLAGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS
       190        200        210        220        230        240
DTFSPYTSPC VSPNNGGPDD LCPQFQNIPA HYSPRTSPIM SPRTSLAEDS CLGRHSPVPR
       250        260        270        280        290        300
PASRSSSPGA KRRHSCAEAL VALPPGASPQ RSRSPSPQPS SHVAPQDHGS PAGYPPVAGS
       310        320        330        340        350        360
AVIMDALNSL ATDSPCGIPP KMWKTSPDPS PVSAAPSKAG LPRHIYPAVE FLGPCEQGER
       370        380        390        400        410        420
RNSAPESILL VPPTWPKPLV PAIPICSIPV TASLPPLEWP LSSQSGSYEL RIEVQPKPHH
       430        440        450        460        470        480
RAHYETEGSR GAVKAPTGGH PVVQLHGYME NKPLGLQIFI GTADERILKP HAFYQVHRIT
       490        500        510        520        530        540
GKTVTTTSYE KIVGNTKVLE IPLEPKNNMR ATIDCAGILK LRNADIELRK GETDIGRKNT
       550        560        570        580        590        600
RVRLVFRVHI PESSGRIVSL QTASNPIECS QRSAHELPMV ERQDTDSCLV YGGQQMILTG
       610        620        630        640        650        660
QNFTSESKVV FTEKTTDGQQ IWEMEATVDK DKSQPNMLFV EIPEYRNKHI RTPVKVNFYV
       670        680        690        700        710        720
INGKRKRSQP QHFTYHPVPA IKTEPTDEYD PTLICSPTHG GLGSQPYYPQ HPMVAESPSC
       730        740        750        760        770        780
LVATMAPCQQ FRTGLSSPDA RYQQQNPAAV LYQRSKSLSP SLLGYQQPAL MAAPLSLADA
       790        800        810        820        830        840
HRSVLVHAGS QGQSSALLHP SPTNQQASPV IHYSPTNQQL RCGSHQEFQH IMYCENFAPG
       850        860        870        880        890        900
TTRPGPPPVS QGQRLSPGSY PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL
       910        920
DQTYLDDVNE IIRKEFSGPP ARNQT         10         20         30         40         50         60
MNAPERQPQP DGGDAPGHEP GGSPQDELDF SILFDYEYLN PNEEEPNAHK VASPPSGPAY
        70         80         90        100        110        120
PDDVLDYGLK PYSPLASLSG EPPGRFGEPD RVGPQKFLSA AKPAGASGLS PRIEITPSHE
       130        140        150        160        170        180
LIQAVGPLRM RDAGLLVEQP PLAGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS
       190        200        210        220        230        240
DTFSPYTSPC VSPNNGGPDD LCPQFQNIPA HYSPRTSPIM SPRTSLAEDS CLGRHSPVPR
       250        260        270        280        290        300
PASRSSSPGA KRRHSCAEAL VALPPGASPQ RSRSPSPQPS SHVAPQDHGS PAGYPPVAGS
       310        320        330        340        350        360
AVIMDALNSL ATDSPCGIPP KMWKTSPDPS PVSAAPSKAG LPRHIYPAVE FLGPCEQGER
       370        380        390        400        410        420
RNSAPESILL VPPTWPKPLV PAIPICSIPV TASLPPLEWP LSSQSGSYEL RIEVQPKPHH
       430        440        450        460        470        480
RAHYETEGSR GAVKAPTGGH PVVQLHGYME NKPLGLQIFI GTADERILKP HAFYQVHRIT
       490        500        510        520        530        540
GKTVTTTSYE KIVGNTKVLE IPLEPKNNMR ATIDCAGILK LRNADIELRK GETDIGRKNT
       550        560        570        580        590        600
RVRLVFRVHI PESSGRIVSL QTASNPIECS QRSAHELPMV ERQDTDSCLV YGGQQMILTG
       610        620        630        640        650        660
QNFTSESKVV FTEKTTDGQQ IWEMEATVDK DKSQPNMLFV EIPEYRNKHI RTPVKVNFYV
       670        680        690        700        710        720
INGKRKRSQP QHFTYHPVPA IKTEPTDEYD PTLICSPTHG GLGSQPYYPQ HPMVAESPSC
       730        740        750        760        770        780
LVATMAPCQQ FRTGLSSPDA RYQQQNPAAV LYQRSKSLSP SLLGYQQPAL MAAPLSLADA
       790        800        810        820        830        840
HRSVLVHAGS QGQSSALLHP SPTNQQASPV IHYSPTNQQL RCGSHQEFQH IMYCENFAPG
       850        860        870        880        890        900
TTRPGPPPVS QGQRLSPGSY PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL
       910        920
DQTYLDDVNE IIRKEFSGPP ARNQT         10         20         30         40         50         60
MNAPERQPQP DGGDAPGHEP GGSPQDELDF SILFDYEYLN PNEEEPNAHK VASPPSGPAY
        70         80         90        100        110        120
PDDVLDYGLK PYSPLASLSG EPPGRFGEPD RVGPQKFLSA AKPAGASGLS PRIEITPSHE
       130        140        150        160        170        180
LIQAVGPLRM RDAGLLVEQP PLAGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS
       190        200        210        220        230        240
DTFSPYTSPC VSPNNGGPDD LCPQFQNIPA HYSPRTSPIM SPRTSLAEDS CLGRHSPVPR
       250        260        270        280        290        300
PASRSSSPGA KRRHSCAEAL VALPPGASPQ RSRSPSPQPS SHVAPQDHGS PAGYPPVAGS
       310        320        330        340        350        360
AVIMDALNSL ATDSPCGIPP KMWKTSPDPS PVSAAPSKAG LPRHIYPAVE FLGPCEQGER
       370        380        390        400        410        420
RNSAPESILL VPPTWPKPLV PAIPICSIPV TASLPPLEWP LSSQSGSYEL RIEVQPKPHH
       430        440        450        460        470        480
RAHYETEGSR GAVKAPTGGH PVVQLHGYME NKPLGLQIFI GTADERILKP HAFYQVHRIT
       490        500        510        520        530        540
GKTVTTTSYE KIVGNTKVLE IPLEPKNNMR ATIDCAGILK LRNADIELRK GETDIGRKNT
       550        560        570        580        590        600
RVRLVFRVHI PESSGRIVSL QTASNPIECS QRSAHELPMV ERQDTDSCLV YGGQQMILTG
       610        620        630        640        650        660
QNFTSESKVV FTEKTTDGQQ IWEMEATVDK DKSQPNMLFV EIPEYRNKHI RTPVKVNFYV
       670        680        690        700        710        720
INGKRKRSQP QHFTYHPVPA IKTEPTDEYD PTLICSPTHG GLGSQPYYPQ HPMVAESPSC
       730        740        750        760        770        780
LVATMAPCQQ FRTGLSSPDA RYQQQNPAAV LYQRSKSLSP SLLGYQQPAL MAAPLSLADA
       790        800        810        820        830        840
HRSVLVHAGS QGQSSALLHP SPTNQQASPV IHYSPTNQQL RCGSHQEFQH IMYCENFAPG
       850        860        870        880        890        900
TTRPGPPPVS QGQRLSPGSY PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL
       910        920
DQTYLDDVNE IIRKEFSGPP ARNQT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13469-1-unknown	MNAPER...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13469-1-unknown	MNAPER...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82683
Q13469-30-unknown	FSILFD...	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2185
Q13469-30-unknown	FSILFD...	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137558
Q13469-67-	YGLKPY...	67		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13469-67-unknown	YGLKPY...	67	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2187
Q13469-67-unknown	YGLKPY...	67	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138904
Q13469-67-unknown	YGLKPY...	67	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138905
Q13469-67-unknown	YGLKPY...	67	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140441
Q13469-68-	GLKPYS...	68		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13469-68-	GLKPYS...	68		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13469-68-	GLKPYS...	68		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13469-68-unknown	GLKPYS...	68	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164558
Q13469-68-unknown	GLKPYS...	68	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164559
Q13469-68-unknown	GLKPYS...	68	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164560
Q13469-101-unknown	AKPAGA...	101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174487
Q13469-101-unknown	AKPAGA...	101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174488
Q13469-101-unknown	AKPAGA...	101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174489
Q13469-101-	AKPAGA...	101		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13469-220-unknown	MSPRTS...	220	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000477142
Q13469-220-unknown	MSPRTS...	220	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000477342
Q13469-220-unknown	MSPRTS...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198229
Q13469-220-unknown	MSPRTS...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198230
Q13469-220-unknown	MSPRTS...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198231
Q13469-764-unknown	GYQQPA...	764	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165065
Q13469-764-unknown	GYQQPA...	764	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165066
Q13469-764-unknown	GYQQPA...	764	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165067
Q13469-764-	GYQQPA...	764		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QDELDF	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2185
...QDELDF	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120543
...DDVLDY	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2187
...DDVLDY	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121969
...DDVLDY	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121970
...DDVLDY	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123567
...ARNQT	925	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ARNQT	925	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78303

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	29	ELDF.\|.FSIL	inferred from experiment	unknown	MEROPS	Budd RC	Wu W et al.:Proteolytic regulation of nucle... (C14.003)	16455648,
CASP3_HUMAN	66	VLDY.\|.YGLK	inferred from experiment	unknown	MEROPS	Budd RC	Wu W et al.:Proteolytic regulation of nucle... (C14.003)	16455648,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)