Q13485: Mothers against decapentaplegic homolog 4

General Information

Protein names	- Mothers against decapentaplegic homolog 4 - MAD homolog 4 - Mothers against DPP homolog 4 - Deletion target in pancreatic carcinoma 4 - SMAD family member 4 - SMAD 4 - Smad4 - hSMAD4
Gene names	SMAD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13485

4 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA
        70         80         90        100        110        120
ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD
       130        140        150        160        170        180
LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSSMMVKD EYVHDFEGQP SLSTEGHSIQ
       190        200        210        220        230        240
TIQHPPSNRA STETYSTPAL LAPSESNATS TANFPNIPVA STSQPASILG GSHSEGLLQI
       250        260        270        280        290        300
ASGPQPGQQQ NGFTGQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH
       310        320        330        340        350        360
YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD
       370        380        390        400        410        420
RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR
       430        440        450        460        470        480
APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP
       490        500        510        520        530        540
AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL
       550
HTMPIADPQP LD

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13485-1-unknown	MDNMSI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13485-157-	MVKDEY...	157		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13485-157-	MVKDEY...	157		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13485-173-	STEGHS...	173		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13485-412-unknown	YYLDRE...	412	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466118

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRKGFP	90	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466934
...QYAFDL	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465874
...KCDSVC	126	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465878
...VVSPGI	140	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464772
...TLQSNA	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466941
...PQPLD	552	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)